| Full name: gasdermin C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q24.21 | ||
| Entrez ID: 56169 | HGNC ID: HGNC:7151 | Ensembl Gene: ENSG00000147697 | OMIM ID: 608384 |
| Drug and gene relationship at DGIdb | |||
Expression of GSDMC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GSDMC | 56169 | 234305_s_at | -0.1228 | 0.9357 | |
| GSE26886 | GSDMC | 56169 | 234305_s_at | -1.1934 | 0.0000 | |
| GSE45670 | GSDMC | 56169 | 234305_s_at | 0.3307 | 0.1911 | |
| GSE53622 | GSDMC | 56169 | 75601 | -0.9480 | 0.0190 | |
| GSE53624 | GSDMC | 56169 | 75601 | -1.2234 | 0.0000 | |
| GSE63941 | GSDMC | 56169 | 234305_s_at | 0.9194 | 0.1991 | |
| GSE77861 | GSDMC | 56169 | 234305_s_at | -0.4229 | 0.1450 | |
| GSE97050 | GSDMC | 56169 | A_33_P3320159 | 0.2889 | 0.5903 | |
| SRP007169 | GSDMC | 56169 | RNAseq | -1.8486 | 0.0003 | |
| SRP008496 | GSDMC | 56169 | RNAseq | -2.1682 | 0.0000 | |
| SRP064894 | GSDMC | 56169 | RNAseq | -0.1826 | 0.6680 | |
| SRP133303 | GSDMC | 56169 | RNAseq | -1.1725 | 0.0000 | |
| SRP159526 | GSDMC | 56169 | RNAseq | -1.9885 | 0.0035 | |
| SRP219564 | GSDMC | 56169 | RNAseq | 0.8591 | 0.5326 | |
| TCGA | GSDMC | 56169 | RNAseq | 1.7218 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by GSDMC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GSDMC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GSDMC | 56169 | 17 | 0 | 13 | |
| GSE20123 | GSDMC | 56169 | 17 | 0 | 13 | |
| GSE43470 | GSDMC | 56169 | 22 | 0 | 21 | |
| GSE46452 | GSDMC | 56169 | 28 | 0 | 31 | |
| GSE47630 | GSDMC | 56169 | 24 | 0 | 16 | |
| GSE54993 | GSDMC | 56169 | 0 | 24 | 46 | |
| GSE54994 | GSDMC | 56169 | 39 | 1 | 13 | |
| GSE60625 | GSDMC | 56169 | 0 | 7 | 4 | |
| GSE74703 | GSDMC | 56169 | 19 | 0 | 17 | |
| GSE74704 | GSDMC | 56169 | 11 | 0 | 9 | |
| TCGA | GSDMC | 56169 | 68 | 1 | 27 |
Total number of gains: 245; Total number of losses: 33; Total Number of normals: 210.
Somatic mutations of GSDMC:
Generating mutation plots.
Highly correlated genes for GSDMC:
Showing top 20/831 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GSDMC | NIPAL1 | 0.747445 | 3 | 0 | 3 |
| GSDMC | RAP2C | 0.742158 | 4 | 0 | 4 |
| GSDMC | UGP2 | 0.705246 | 3 | 0 | 3 |
| GSDMC | SLC10A7 | 0.705189 | 3 | 0 | 3 |
| GSDMC | STOML2 | 0.703348 | 3 | 0 | 3 |
| GSDMC | FAM83A | 0.700951 | 6 | 0 | 6 |
| GSDMC | PGK1 | 0.699631 | 4 | 0 | 4 |
| GSDMC | DHCR24 | 0.694536 | 5 | 0 | 5 |
| GSDMC | GBE1 | 0.69401 | 5 | 0 | 4 |
| GSDMC | PGM2 | 0.69287 | 8 | 0 | 6 |
| GSDMC | PGLYRP3 | 0.690089 | 4 | 0 | 3 |
| GSDMC | CCDC25 | 0.687255 | 3 | 0 | 3 |
| GSDMC | SRD5A1 | 0.686748 | 5 | 0 | 4 |
| GSDMC | TGM1 | 0.68669 | 7 | 0 | 7 |
| GSDMC | QRICH1 | 0.686463 | 3 | 0 | 3 |
| GSDMC | CHRNB1 | 0.68575 | 3 | 0 | 3 |
| GSDMC | CBR1 | 0.683341 | 3 | 0 | 3 |
| GSDMC | DCAF10 | 0.681383 | 3 | 0 | 3 |
| GSDMC | PBDC1 | 0.681311 | 3 | 0 | 3 |
| GSDMC | LAMP2 | 0.680904 | 5 | 0 | 4 |
For details and further investigation, click here
