| Full name: glycine C-acetyltransferase | Alias Symbol: KBL | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 23464 | HGNC ID: HGNC:4188 | Ensembl Gene: ENSG00000100116 | OMIM ID: 607422 |
| Drug and gene relationship at DGIdb | |||
Expression of GCAT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCAT | 23464 | 36475_at | 0.0053 | 0.9900 | |
| GSE20347 | GCAT | 23464 | 205164_at | -0.3154 | 0.0441 | |
| GSE23400 | GCAT | 23464 | 36475_at | -0.2124 | 0.0000 | |
| GSE26886 | GCAT | 23464 | 205164_at | 0.0954 | 0.7382 | |
| GSE29001 | GCAT | 23464 | 36475_at | -0.7569 | 0.0001 | |
| GSE38129 | GCAT | 23464 | 205164_at | -0.2616 | 0.0909 | |
| GSE45670 | GCAT | 23464 | 36475_at | 0.0566 | 0.7845 | |
| GSE53622 | GCAT | 23464 | 139107 | -0.6709 | 0.0006 | |
| GSE53624 | GCAT | 23464 | 139107 | -0.5009 | 0.0001 | |
| GSE63941 | GCAT | 23464 | 205164_at | -0.1114 | 0.8800 | |
| GSE77861 | GCAT | 23464 | 36475_at | -0.1891 | 0.2628 | |
| SRP007169 | GCAT | 23464 | RNAseq | -1.7456 | 0.0038 | |
| SRP008496 | GCAT | 23464 | RNAseq | -1.6353 | 0.0000 | |
| SRP064894 | GCAT | 23464 | RNAseq | -0.2630 | 0.4557 | |
| SRP133303 | GCAT | 23464 | RNAseq | -0.4946 | 0.0813 | |
| SRP159526 | GCAT | 23464 | RNAseq | 0.0319 | 0.9332 | |
| SRP193095 | GCAT | 23464 | RNAseq | -0.6444 | 0.0001 | |
| SRP219564 | GCAT | 23464 | RNAseq | -0.3653 | 0.0861 | |
| TCGA | GCAT | 23464 | RNAseq | -0.1031 | 0.3553 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GCAT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCAT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCAT | 23464 | 6 | 5 | 19 | |
| GSE20123 | GCAT | 23464 | 6 | 4 | 20 | |
| GSE43470 | GCAT | 23464 | 4 | 6 | 33 | |
| GSE46452 | GCAT | 23464 | 32 | 2 | 25 | |
| GSE47630 | GCAT | 23464 | 9 | 4 | 27 | |
| GSE54993 | GCAT | 23464 | 3 | 6 | 61 | |
| GSE54994 | GCAT | 23464 | 9 | 8 | 36 | |
| GSE60625 | GCAT | 23464 | 5 | 0 | 6 | |
| GSE74703 | GCAT | 23464 | 4 | 4 | 28 | |
| GSE74704 | GCAT | 23464 | 3 | 2 | 15 | |
| TCGA | GCAT | 23464 | 27 | 15 | 54 |
Total number of gains: 108; Total number of losses: 56; Total Number of normals: 324.
Somatic mutations of GCAT:
Generating mutation plots.
Highly correlated genes for GCAT:
Showing top 20/188 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCAT | GALR2 | 0.666692 | 4 | 0 | 4 |
| GCAT | RHOG | 0.634803 | 5 | 0 | 3 |
| GCAT | RABEP2 | 0.630923 | 4 | 0 | 3 |
| GCAT | ARHGEF15 | 0.630067 | 3 | 0 | 3 |
| GCAT | TRMT10A | 0.62519 | 3 | 0 | 3 |
| GCAT | MVB12A | 0.624009 | 4 | 0 | 4 |
| GCAT | KDF1 | 0.622252 | 3 | 0 | 3 |
| GCAT | GFOD2 | 0.621837 | 5 | 0 | 5 |
| GCAT | CNOT11 | 0.612217 | 3 | 0 | 3 |
| GCAT | SMURF1 | 0.610536 | 3 | 0 | 3 |
| GCAT | NLRX1 | 0.609445 | 5 | 0 | 3 |
| GCAT | CSNK1G1 | 0.608164 | 4 | 0 | 3 |
| GCAT | FUT6 | 0.606162 | 5 | 0 | 3 |
| GCAT | MVK | 0.602933 | 5 | 0 | 4 |
| GCAT | ERBB2 | 0.601889 | 5 | 0 | 4 |
| GCAT | TSTD1 | 0.60163 | 5 | 0 | 3 |
| GCAT | PRRG2 | 0.601485 | 7 | 0 | 5 |
| GCAT | TIMM13 | 0.601434 | 5 | 0 | 3 |
| GCAT | RCAN3 | 0.600998 | 4 | 0 | 3 |
| GCAT | HIP1R | 0.600469 | 3 | 0 | 3 |
For details and further investigation, click here
