| Full name: ras homolog family member G | Alias Symbol: RhoG|MGC125835|MGC125836 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 391 | HGNC ID: HGNC:672 | Ensembl Gene: ENSG00000177105 | OMIM ID: 179505 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RHOG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05100 | Bacterial invasion of epithelial cells | |
| hsa05131 | Shigellosis | |
| hsa05132 | Salmonella infection |
Expression of RHOG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RHOG | 391 | 203175_at | -0.2295 | 0.5948 | |
| GSE20347 | RHOG | 391 | 203175_at | -0.8432 | 0.0000 | |
| GSE23400 | RHOG | 391 | 203175_at | -0.3349 | 0.0000 | |
| GSE26886 | RHOG | 391 | 203175_at | -0.7318 | 0.0018 | |
| GSE29001 | RHOG | 391 | 203175_at | -0.8735 | 0.0070 | |
| GSE38129 | RHOG | 391 | 203175_at | -0.5393 | 0.0000 | |
| GSE45670 | RHOG | 391 | 203175_at | -0.0757 | 0.6173 | |
| GSE53622 | RHOG | 391 | 120035 | -0.1828 | 0.1317 | |
| GSE53624 | RHOG | 391 | 120035 | -0.3448 | 0.0035 | |
| GSE63941 | RHOG | 391 | 203175_at | -0.0830 | 0.8617 | |
| GSE77861 | RHOG | 391 | 203175_at | -0.2176 | 0.4471 | |
| GSE97050 | RHOG | 391 | A_33_P3317376 | 0.2810 | 0.4483 | |
| SRP007169 | RHOG | 391 | RNAseq | -1.2443 | 0.0061 | |
| SRP008496 | RHOG | 391 | RNAseq | -1.1057 | 0.0000 | |
| SRP064894 | RHOG | 391 | RNAseq | -0.1727 | 0.5489 | |
| SRP133303 | RHOG | 391 | RNAseq | -0.3221 | 0.0306 | |
| SRP159526 | RHOG | 391 | RNAseq | -1.0105 | 0.0014 | |
| SRP193095 | RHOG | 391 | RNAseq | -0.4264 | 0.0076 | |
| SRP219564 | RHOG | 391 | RNAseq | -0.2257 | 0.4749 | |
| TCGA | RHOG | 391 | RNAseq | 0.1264 | 0.0206 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by RHOG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RHOG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RHOG | 391 | 1 | 12 | 17 | |
| GSE20123 | RHOG | 391 | 1 | 11 | 18 | |
| GSE43470 | RHOG | 391 | 1 | 8 | 34 | |
| GSE46452 | RHOG | 391 | 7 | 8 | 44 | |
| GSE47630 | RHOG | 391 | 4 | 12 | 24 | |
| GSE54993 | RHOG | 391 | 3 | 1 | 66 | |
| GSE54994 | RHOG | 391 | 1 | 12 | 40 | |
| GSE60625 | RHOG | 391 | 0 | 0 | 11 | |
| GSE74703 | RHOG | 391 | 1 | 7 | 28 | |
| GSE74704 | RHOG | 391 | 0 | 8 | 12 | |
| TCGA | RHOG | 391 | 7 | 38 | 51 |
Total number of gains: 26; Total number of losses: 117; Total Number of normals: 345.
Somatic mutations of RHOG:
Generating mutation plots.
Highly correlated genes for RHOG:
Showing top 20/1257 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RHOG | PTPN23 | 0.793889 | 3 | 0 | 3 |
| RHOG | RAB11B | 0.778422 | 3 | 0 | 3 |
| RHOG | PHF23 | 0.76096 | 3 | 0 | 3 |
| RHOG | CST7 | 0.732813 | 3 | 0 | 3 |
| RHOG | ORMDL2 | 0.730008 | 8 | 0 | 8 |
| RHOG | PMF1 | 0.72901 | 3 | 0 | 3 |
| RHOG | PMM2 | 0.726606 | 3 | 0 | 3 |
| RHOG | AKIP1 | 0.724544 | 4 | 0 | 4 |
| RHOG | EXOC4 | 0.723679 | 3 | 0 | 3 |
| RHOG | ATRIP | 0.722965 | 3 | 0 | 3 |
| RHOG | VRK3 | 0.716875 | 4 | 0 | 4 |
| RHOG | SLC35D2 | 0.715894 | 4 | 0 | 4 |
| RHOG | ZNF747 | 0.713659 | 4 | 0 | 3 |
| RHOG | PPT2 | 0.71351 | 3 | 0 | 3 |
| RHOG | ETS1 | 0.712826 | 3 | 0 | 3 |
| RHOG | MDFIC | 0.707241 | 4 | 0 | 4 |
| RHOG | RAB11A | 0.700406 | 8 | 0 | 7 |
| RHOG | RILP | 0.697264 | 4 | 0 | 3 |
| RHOG | GIPC1 | 0.695452 | 10 | 0 | 10 |
| RHOG | GIMAP6 | 0.695387 | 3 | 0 | 3 |
For details and further investigation, click here
