| Full name: Rho guanine nucleotide exchange factor 15 | Alias Symbol: KIAA0915|Vsm-RhoGEF|ARGEF15|FLJ13791|MGC44868 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 22899 | HGNC ID: HGNC:15590 | Ensembl Gene: ENSG00000198844 | OMIM ID: 608504 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGEF15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF15 | 22899 | 217348_x_at | -0.0431 | 0.8648 | |
| GSE20347 | ARHGEF15 | 22899 | 217348_x_at | 0.1014 | 0.3395 | |
| GSE23400 | ARHGEF15 | 22899 | 217348_x_at | -0.1423 | 0.0001 | |
| GSE26886 | ARHGEF15 | 22899 | 217348_x_at | -0.0446 | 0.6988 | |
| GSE29001 | ARHGEF15 | 22899 | 205507_at | -0.3045 | 0.0074 | |
| GSE38129 | ARHGEF15 | 22899 | 217348_x_at | -0.0782 | 0.4183 | |
| GSE45670 | ARHGEF15 | 22899 | 217348_x_at | -0.0226 | 0.8107 | |
| GSE63941 | ARHGEF15 | 22899 | 217348_x_at | 0.0897 | 0.5570 | |
| GSE77861 | ARHGEF15 | 22899 | 217348_x_at | -0.0685 | 0.5277 | |
| GSE97050 | ARHGEF15 | 22899 | A_23_P49674 | -0.1128 | 0.7072 | |
| SRP007169 | ARHGEF15 | 22899 | RNAseq | 0.1088 | 0.8539 | |
| SRP064894 | ARHGEF15 | 22899 | RNAseq | 0.4236 | 0.2341 | |
| SRP133303 | ARHGEF15 | 22899 | RNAseq | -0.8237 | 0.0009 | |
| SRP159526 | ARHGEF15 | 22899 | RNAseq | -0.5059 | 0.2606 | |
| SRP193095 | ARHGEF15 | 22899 | RNAseq | 0.4434 | 0.0509 | |
| SRP219564 | ARHGEF15 | 22899 | RNAseq | -0.4025 | 0.5335 | |
| TCGA | ARHGEF15 | 22899 | RNAseq | -0.6788 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARHGEF15 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF15 | 22899 | 4 | 2 | 24 | |
| GSE20123 | ARHGEF15 | 22899 | 4 | 3 | 23 | |
| GSE43470 | ARHGEF15 | 22899 | 1 | 6 | 36 | |
| GSE46452 | ARHGEF15 | 22899 | 34 | 1 | 24 | |
| GSE47630 | ARHGEF15 | 22899 | 7 | 1 | 32 | |
| GSE54993 | ARHGEF15 | 22899 | 4 | 3 | 63 | |
| GSE54994 | ARHGEF15 | 22899 | 5 | 8 | 40 | |
| GSE60625 | ARHGEF15 | 22899 | 4 | 0 | 7 | |
| GSE74703 | ARHGEF15 | 22899 | 1 | 3 | 32 | |
| GSE74704 | ARHGEF15 | 22899 | 2 | 1 | 17 | |
| TCGA | ARHGEF15 | 22899 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of ARHGEF15:
Generating mutation plots.
Highly correlated genes for ARHGEF15:
Showing top 20/681 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF15 | UBQLN4 | 0.769229 | 3 | 0 | 3 |
| ARHGEF15 | ZNF540 | 0.75614 | 3 | 0 | 3 |
| ARHGEF15 | MAMDC4 | 0.750847 | 3 | 0 | 3 |
| ARHGEF15 | BCORL1 | 0.74367 | 3 | 0 | 3 |
| ARHGEF15 | ZNF345 | 0.742924 | 3 | 0 | 3 |
| ARHGEF15 | GPA33 | 0.723289 | 3 | 0 | 3 |
| ARHGEF15 | CCDC159 | 0.720322 | 3 | 0 | 3 |
| ARHGEF15 | EDA2R | 0.71522 | 6 | 0 | 6 |
| ARHGEF15 | RNASEH2B | 0.714319 | 3 | 0 | 3 |
| ARHGEF15 | AVP | 0.713626 | 5 | 0 | 4 |
| ARHGEF15 | ITGA8 | 0.705892 | 3 | 0 | 3 |
| ARHGEF15 | HAUS2 | 0.701458 | 4 | 0 | 3 |
| ARHGEF15 | C9orf50 | 0.695956 | 3 | 0 | 3 |
| ARHGEF15 | ADARB1 | 0.695238 | 3 | 0 | 3 |
| ARHGEF15 | DIP2A | 0.683802 | 4 | 0 | 3 |
| ARHGEF15 | LRRC36 | 0.683375 | 6 | 0 | 5 |
| ARHGEF15 | DMRTA1 | 0.683374 | 3 | 0 | 3 |
| ARHGEF15 | VPS28 | 0.679487 | 3 | 0 | 3 |
| ARHGEF15 | CAB39L | 0.677133 | 3 | 0 | 3 |
| ARHGEF15 | OPHN1 | 0.673702 | 6 | 0 | 5 |
For details and further investigation, click here
