| Full name: glutaryl-CoA dehydrogenase | Alias Symbol: ACAD5 | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 2639 | HGNC ID: HGNC:4189 | Ensembl Gene: ENSG00000105607 | OMIM ID: 608801 |
| Drug and gene relationship at DGIdb | |||
Expression of GCDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCDH | 2639 | 203500_at | 0.5311 | 0.4324 | |
| GSE20347 | GCDH | 2639 | 203500_at | 0.1878 | 0.0693 | |
| GSE23400 | GCDH | 2639 | 208369_s_at | 0.2024 | 0.0051 | |
| GSE26886 | GCDH | 2639 | 203500_at | -0.1297 | 0.4533 | |
| GSE29001 | GCDH | 2639 | 208369_s_at | 0.0681 | 0.8018 | |
| GSE38129 | GCDH | 2639 | 203500_at | 0.1190 | 0.1837 | |
| GSE45670 | GCDH | 2639 | 203500_at | 0.1747 | 0.2314 | |
| GSE53622 | GCDH | 2639 | 59895 | -0.2182 | 0.0037 | |
| GSE53624 | GCDH | 2639 | 59895 | 0.0394 | 0.6279 | |
| GSE63941 | GCDH | 2639 | 208369_s_at | 0.6070 | 0.1805 | |
| GSE77861 | GCDH | 2639 | 203500_at | 0.0942 | 0.5609 | |
| GSE97050 | GCDH | 2639 | A_23_P90089 | 0.1541 | 0.5142 | |
| SRP007169 | GCDH | 2639 | RNAseq | -0.0777 | 0.8299 | |
| SRP008496 | GCDH | 2639 | RNAseq | -0.1678 | 0.5195 | |
| SRP064894 | GCDH | 2639 | RNAseq | 0.3185 | 0.1467 | |
| SRP133303 | GCDH | 2639 | RNAseq | 0.0367 | 0.8728 | |
| SRP159526 | GCDH | 2639 | RNAseq | 0.1377 | 0.6521 | |
| SRP193095 | GCDH | 2639 | RNAseq | -0.0674 | 0.5456 | |
| SRP219564 | GCDH | 2639 | RNAseq | 0.4698 | 0.3050 | |
| TCGA | GCDH | 2639 | RNAseq | -0.0261 | 0.6968 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GCDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCDH | 2639 | 4 | 2 | 24 | |
| GSE20123 | GCDH | 2639 | 3 | 1 | 26 | |
| GSE43470 | GCDH | 2639 | 2 | 6 | 35 | |
| GSE46452 | GCDH | 2639 | 47 | 1 | 11 | |
| GSE47630 | GCDH | 2639 | 4 | 7 | 29 | |
| GSE54993 | GCDH | 2639 | 16 | 3 | 51 | |
| GSE54994 | GCDH | 2639 | 8 | 13 | 32 | |
| GSE60625 | GCDH | 2639 | 9 | 0 | 2 | |
| GSE74703 | GCDH | 2639 | 2 | 4 | 30 | |
| GSE74704 | GCDH | 2639 | 0 | 1 | 19 | |
| TCGA | GCDH | 2639 | 17 | 12 | 67 |
Total number of gains: 112; Total number of losses: 50; Total Number of normals: 326.
Somatic mutations of GCDH:
Generating mutation plots.
Highly correlated genes for GCDH:
Showing top 20/599 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCDH | FBXW8 | 0.808945 | 3 | 0 | 3 |
| GCDH | PAPOLG | 0.805917 | 3 | 0 | 3 |
| GCDH | TBC1D22B | 0.800413 | 3 | 0 | 3 |
| GCDH | CNOT10 | 0.794161 | 3 | 0 | 3 |
| GCDH | CASKIN2 | 0.787141 | 3 | 0 | 3 |
| GCDH | ZNF408 | 0.786966 | 3 | 0 | 3 |
| GCDH | ZNF830 | 0.785616 | 3 | 0 | 3 |
| GCDH | SLC25A19 | 0.784416 | 3 | 0 | 3 |
| GCDH | TMCO4 | 0.777022 | 3 | 0 | 3 |
| GCDH | UBL5 | 0.766172 | 4 | 0 | 4 |
| GCDH | MRPL51 | 0.761171 | 3 | 0 | 3 |
| GCDH | PLEKHJ1 | 0.760799 | 3 | 0 | 3 |
| GCDH | PPP6R2 | 0.757977 | 3 | 0 | 3 |
| GCDH | DMAP1 | 0.754644 | 3 | 0 | 3 |
| GCDH | PRADC1 | 0.752319 | 3 | 0 | 3 |
| GCDH | CCDC15 | 0.749818 | 3 | 0 | 3 |
| GCDH | RBM15B | 0.741292 | 3 | 0 | 3 |
| GCDH | GPR107 | 0.738151 | 3 | 0 | 3 |
| GCDH | APEH | 0.736114 | 3 | 0 | 3 |
| GCDH | PHF8 | 0.735272 | 3 | 0 | 3 |
For details and further investigation, click here
