| Full name: F-box and WD repeat domain containing 8 | Alias Symbol: FBX29|FBW6|FBW8 | ||
| Type: protein-coding gene | Cytoband: 12q24.22 | ||
| Entrez ID: 26259 | HGNC ID: HGNC:13597 | Ensembl Gene: ENSG00000174989 | OMIM ID: 609073 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXW8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXW8 | 26259 | 231883_at | 0.1104 | 0.6582 | |
| GSE26886 | FBXW8 | 26259 | 231883_at | 0.1137 | 0.4016 | |
| GSE45670 | FBXW8 | 26259 | 231883_at | 0.0541 | 0.6132 | |
| GSE53622 | FBXW8 | 26259 | 143989 | 0.3985 | 0.0000 | |
| GSE53624 | FBXW8 | 26259 | 143989 | 0.5278 | 0.0000 | |
| GSE63941 | FBXW8 | 26259 | 231883_at | -0.1397 | 0.5559 | |
| GSE77861 | FBXW8 | 26259 | 231883_at | 0.0185 | 0.8174 | |
| GSE97050 | FBXW8 | 26259 | A_24_P44279 | -0.0900 | 0.6923 | |
| SRP007169 | FBXW8 | 26259 | RNAseq | 1.1363 | 0.0106 | |
| SRP008496 | FBXW8 | 26259 | RNAseq | 1.1345 | 0.0004 | |
| SRP064894 | FBXW8 | 26259 | RNAseq | 0.3837 | 0.0299 | |
| SRP133303 | FBXW8 | 26259 | RNAseq | 0.1192 | 0.3120 | |
| SRP159526 | FBXW8 | 26259 | RNAseq | 0.4952 | 0.0960 | |
| SRP193095 | FBXW8 | 26259 | RNAseq | 0.1687 | 0.3208 | |
| SRP219564 | FBXW8 | 26259 | RNAseq | 0.4698 | 0.0277 | |
| TCGA | FBXW8 | 26259 | RNAseq | -0.1300 | 0.0160 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FBXW8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXW8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXW8 | 26259 | 4 | 3 | 23 | |
| GSE20123 | FBXW8 | 26259 | 4 | 3 | 23 | |
| GSE43470 | FBXW8 | 26259 | 2 | 0 | 41 | |
| GSE46452 | FBXW8 | 26259 | 9 | 1 | 49 | |
| GSE47630 | FBXW8 | 26259 | 9 | 3 | 28 | |
| GSE54993 | FBXW8 | 26259 | 0 | 5 | 65 | |
| GSE54994 | FBXW8 | 26259 | 6 | 5 | 42 | |
| GSE60625 | FBXW8 | 26259 | 0 | 0 | 11 | |
| GSE74703 | FBXW8 | 26259 | 2 | 0 | 34 | |
| GSE74704 | FBXW8 | 26259 | 2 | 2 | 16 | |
| TCGA | FBXW8 | 26259 | 21 | 10 | 65 |
Total number of gains: 59; Total number of losses: 32; Total Number of normals: 397.
Somatic mutations of FBXW8:
Generating mutation plots.
Highly correlated genes for FBXW8:
Showing top 20/249 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXW8 | FAM32A | 0.822659 | 3 | 0 | 3 |
| FBXW8 | LDLRAP1 | 0.817112 | 3 | 0 | 3 |
| FBXW8 | ANAPC5 | 0.809681 | 3 | 0 | 3 |
| FBXW8 | GCDH | 0.808945 | 3 | 0 | 3 |
| FBXW8 | ARF3 | 0.801377 | 3 | 0 | 3 |
| FBXW8 | CSTF2T | 0.788182 | 3 | 0 | 3 |
| FBXW8 | MRPL20 | 0.788006 | 3 | 0 | 3 |
| FBXW8 | MDH2 | 0.781178 | 3 | 0 | 3 |
| FBXW8 | MLLT1 | 0.766749 | 3 | 0 | 3 |
| FBXW8 | NIPAL3 | 0.766389 | 3 | 0 | 3 |
| FBXW8 | PEX10 | 0.75759 | 3 | 0 | 3 |
| FBXW8 | TRUB1 | 0.756488 | 3 | 0 | 3 |
| FBXW8 | ATP6V0B | 0.751016 | 3 | 0 | 3 |
| FBXW8 | ZNF121 | 0.741319 | 3 | 0 | 3 |
| FBXW8 | SRSF10 | 0.738495 | 3 | 0 | 3 |
| FBXW8 | ATG3 | 0.735528 | 3 | 0 | 3 |
| FBXW8 | POLR2J | 0.734373 | 3 | 0 | 3 |
| FBXW8 | MCM3AP | 0.733613 | 3 | 0 | 3 |
| FBXW8 | PRPS2 | 0.729078 | 3 | 0 | 3 |
| FBXW8 | SEPHS1 | 0.72229 | 3 | 0 | 3 |
For details and further investigation, click here
