| Full name: gap junction protein gamma 1 | Alias Symbol: CX45 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 10052 | HGNC ID: HGNC:4280 | Ensembl Gene: ENSG00000182963 | OMIM ID: 608655 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GJC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJC1 | 10052 | 228776_at | 0.1980 | 0.8474 | |
| GSE20347 | GJC1 | 10052 | 208460_at | 0.2360 | 0.0057 | |
| GSE23400 | GJC1 | 10052 | 208460_at | 0.0463 | 0.2763 | |
| GSE26886 | GJC1 | 10052 | 228776_at | 2.0431 | 0.0001 | |
| GSE29001 | GJC1 | 10052 | 208460_at | 0.1072 | 0.4568 | |
| GSE38129 | GJC1 | 10052 | 208460_at | 0.1864 | 0.0447 | |
| GSE45670 | GJC1 | 10052 | 228776_at | -0.1959 | 0.7617 | |
| GSE53622 | GJC1 | 10052 | 36569 | -1.9050 | 0.0000 | |
| GSE53624 | GJC1 | 10052 | 36569 | -1.0545 | 0.0000 | |
| GSE63941 | GJC1 | 10052 | 228776_at | -0.4642 | 0.5205 | |
| GSE77861 | GJC1 | 10052 | 208460_at | 0.0648 | 0.5039 | |
| GSE97050 | GJC1 | 10052 | A_33_P3373358 | -1.0440 | 0.0782 | |
| SRP007169 | GJC1 | 10052 | RNAseq | 2.2350 | 0.0005 | |
| SRP008496 | GJC1 | 10052 | RNAseq | 2.3081 | 0.0000 | |
| SRP064894 | GJC1 | 10052 | RNAseq | 1.0847 | 0.0000 | |
| SRP133303 | GJC1 | 10052 | RNAseq | 0.5080 | 0.0175 | |
| SRP159526 | GJC1 | 10052 | RNAseq | 1.4772 | 0.0013 | |
| SRP193095 | GJC1 | 10052 | RNAseq | 1.4132 | 0.0000 | |
| SRP219564 | GJC1 | 10052 | RNAseq | -0.0960 | 0.8686 | |
| TCGA | GJC1 | 10052 | RNAseq | 0.0881 | 0.5515 |
Upregulated datasets: 6; Downregulated datasets: 2.
Survival by GJC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GJC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJC1 | 10052 | 6 | 2 | 22 | |
| GSE20123 | GJC1 | 10052 | 6 | 2 | 22 | |
| GSE43470 | GJC1 | 10052 | 1 | 2 | 40 | |
| GSE46452 | GJC1 | 10052 | 32 | 0 | 27 | |
| GSE47630 | GJC1 | 10052 | 9 | 0 | 31 | |
| GSE54993 | GJC1 | 10052 | 3 | 4 | 63 | |
| GSE54994 | GJC1 | 10052 | 8 | 7 | 38 | |
| GSE60625 | GJC1 | 10052 | 4 | 0 | 7 | |
| GSE74703 | GJC1 | 10052 | 1 | 1 | 34 | |
| GSE74704 | GJC1 | 10052 | 4 | 1 | 15 | |
| TCGA | GJC1 | 10052 | 27 | 6 | 63 |
Total number of gains: 101; Total number of losses: 25; Total Number of normals: 362.
Somatic mutations of GJC1:
Generating mutation plots.
Highly correlated genes for GJC1:
Showing top 20/175 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJC1 | MAP1B | 0.697206 | 5 | 0 | 5 |
| GJC1 | PKD1L2 | 0.696696 | 3 | 0 | 3 |
| GJC1 | RHOQ | 0.69388 | 5 | 0 | 4 |
| GJC1 | NID2 | 0.689951 | 4 | 0 | 3 |
| GJC1 | GPR161 | 0.68766 | 3 | 0 | 3 |
| GJC1 | HRCT1 | 0.67254 | 3 | 0 | 3 |
| GJC1 | CORO6 | 0.672255 | 3 | 0 | 3 |
| GJC1 | LINC00888 | 0.665814 | 3 | 0 | 3 |
| GJC1 | MARVELD1 | 0.658143 | 5 | 0 | 4 |
| GJC1 | PCDH7 | 0.657266 | 3 | 0 | 3 |
| GJC1 | PHF12 | 0.653095 | 4 | 0 | 4 |
| GJC1 | DOCK11 | 0.651132 | 4 | 0 | 3 |
| GJC1 | SOBP | 0.649955 | 4 | 0 | 3 |
| GJC1 | ANTXR2 | 0.646953 | 4 | 0 | 4 |
| GJC1 | SGCB | 0.642754 | 4 | 0 | 4 |
| GJC1 | TBC1D1 | 0.64132 | 5 | 0 | 4 |
| GJC1 | RGS9 | 0.638898 | 4 | 0 | 3 |
| GJC1 | FERMT2 | 0.637124 | 5 | 0 | 3 |
| GJC1 | RNF115 | 0.635194 | 4 | 0 | 3 |
| GJC1 | GRASP | 0.626355 | 4 | 0 | 3 |
For details and further investigation, click here
