| Full name: G protein-coupled receptor 161 | Alias Symbol: RE2 | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 23432 | HGNC ID: HGNC:23694 | Ensembl Gene: ENSG00000143147 | OMIM ID: 612250 |
| Drug and gene relationship at DGIdb | |||
GPR161 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway |
Expression of GPR161:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR161 | 23432 | 214104_at | 0.1685 | 0.8797 | |
| GSE20347 | GPR161 | 23432 | 214104_at | 1.0208 | 0.0069 | |
| GSE23400 | GPR161 | 23432 | 206971_at | -0.1214 | 0.0009 | |
| GSE26886 | GPR161 | 23432 | 214104_at | 2.2058 | 0.0000 | |
| GSE29001 | GPR161 | 23432 | 214104_at | 1.3669 | 0.0403 | |
| GSE38129 | GPR161 | 23432 | 214104_at | 0.9241 | 0.0006 | |
| GSE45670 | GPR161 | 23432 | 214104_at | 0.1153 | 0.7911 | |
| GSE53622 | GPR161 | 23432 | 112434 | 0.1690 | 0.2264 | |
| GSE53624 | GPR161 | 23432 | 68321 | 0.1335 | 0.1632 | |
| GSE63941 | GPR161 | 23432 | 214104_at | -1.3067 | 0.0494 | |
| GSE77861 | GPR161 | 23432 | 206971_at | -0.1164 | 0.3330 | |
| GSE97050 | GPR161 | 23432 | A_23_P103532 | 0.2575 | 0.2589 | |
| SRP007169 | GPR161 | 23432 | RNAseq | 2.5467 | 0.0001 | |
| SRP008496 | GPR161 | 23432 | RNAseq | 2.6127 | 0.0000 | |
| SRP064894 | GPR161 | 23432 | RNAseq | 0.1892 | 0.5061 | |
| SRP133303 | GPR161 | 23432 | RNAseq | 0.5477 | 0.0983 | |
| SRP159526 | GPR161 | 23432 | RNAseq | 0.5928 | 0.1316 | |
| SRP193095 | GPR161 | 23432 | RNAseq | 1.5961 | 0.0000 | |
| SRP219564 | GPR161 | 23432 | RNAseq | -0.6174 | 0.2493 | |
| TCGA | GPR161 | 23432 | RNAseq | 0.3153 | 0.0187 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by GPR161 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR161:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR161 | 23432 | 11 | 1 | 18 | |
| GSE20123 | GPR161 | 23432 | 11 | 1 | 18 | |
| GSE43470 | GPR161 | 23432 | 7 | 2 | 34 | |
| GSE46452 | GPR161 | 23432 | 3 | 1 | 55 | |
| GSE47630 | GPR161 | 23432 | 14 | 0 | 26 | |
| GSE54993 | GPR161 | 23432 | 0 | 6 | 64 | |
| GSE54994 | GPR161 | 23432 | 16 | 0 | 37 | |
| GSE60625 | GPR161 | 23432 | 0 | 0 | 11 | |
| GSE74703 | GPR161 | 23432 | 7 | 2 | 27 | |
| GSE74704 | GPR161 | 23432 | 5 | 0 | 15 | |
| TCGA | GPR161 | 23432 | 44 | 3 | 49 |
Total number of gains: 118; Total number of losses: 16; Total Number of normals: 354.
Somatic mutations of GPR161:
Generating mutation plots.
Highly correlated genes for GPR161:
Showing top 20/336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR161 | HEATR6 | 0.7472 | 3 | 0 | 3 |
| GPR161 | LRPAP1 | 0.724451 | 3 | 0 | 3 |
| GPR161 | GJC1 | 0.68766 | 3 | 0 | 3 |
| GPR161 | RIN3 | 0.680258 | 3 | 0 | 3 |
| GPR161 | CD36 | 0.675135 | 3 | 0 | 3 |
| GPR161 | TCTN1 | 0.672941 | 3 | 0 | 3 |
| GPR161 | SOX11 | 0.667287 | 3 | 0 | 3 |
| GPR161 | GPC3 | 0.661225 | 4 | 0 | 4 |
| GPR161 | TTC7B | 0.652907 | 5 | 0 | 4 |
| GPR161 | SLC38A10 | 0.648423 | 3 | 0 | 3 |
| GPR161 | NAV1 | 0.645036 | 4 | 0 | 4 |
| GPR161 | GRAMD1A | 0.644814 | 4 | 0 | 3 |
| GPR161 | ZNF827 | 0.642895 | 4 | 0 | 3 |
| GPR161 | FARP1 | 0.642433 | 8 | 0 | 7 |
| GPR161 | GGT5 | 0.640734 | 3 | 0 | 3 |
| GPR161 | ACBD6 | 0.638095 | 4 | 0 | 3 |
| GPR161 | RAB15 | 0.635268 | 6 | 0 | 4 |
| GPR161 | RAD23A | 0.634494 | 4 | 0 | 3 |
| GPR161 | HIBADH | 0.63322 | 4 | 0 | 3 |
| GPR161 | OLA1 | 0.631811 | 3 | 0 | 3 |
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