PHF12

 

Full name: PHD finger protein 12 Alias Symbol: PF1|KIAA1523
Type: protein-coding gene Cytoband: 17q11.2
Entrez ID: 57649 HGNC ID: HGNC:20816 Ensembl Gene: ENSG00000109118 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PHF12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PHF12 57649 231815_at 0.6412 0.0450
GSE26886 PHF12 57649 231815_at 0.6378 0.0007
GSE45670 PHF12 57649 231815_at 0.4475 0.0308
GSE53622 PHF12 57649 69714 -1.5244 0.0000
GSE53624 PHF12 57649 69714 -2.3215 0.0000
GSE63941 PHF12 57649 231815_at 0.2729 0.4594
GSE77861 PHF12 57649 231815_at 0.7241 0.0123
GSE97050 PHF12 57649 A_33_P3252889 -0.5787 0.1728
SRP007169 PHF12 57649 RNAseq 0.8198 0.0380
SRP008496 PHF12 57649 RNAseq 0.3926 0.0935
SRP064894 PHF12 57649 RNAseq 0.3437 0.0341
SRP133303 PHF12 57649 RNAseq 0.3084 0.0043
SRP159526 PHF12 57649 RNAseq 0.4691 0.0761
SRP193095 PHF12 57649 RNAseq 0.5294 0.0000
SRP219564 PHF12 57649 RNAseq 0.0893 0.7180
TCGA PHF12 57649 RNAseq -0.0034 0.9405

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by PHF12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PHF12:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PHF12 57649 10 1 19
GSE20123 PHF12 57649 10 1 19
GSE43470 PHF12 57649 0 1 42
GSE46452 PHF12 57649 33 1 25
GSE47630 PHF12 57649 7 1 32
GSE54993 PHF12 57649 2 3 65
GSE54994 PHF12 57649 7 6 40
GSE60625 PHF12 57649 4 0 7
GSE74703 PHF12 57649 0 1 35
GSE74704 PHF12 57649 7 1 12
TCGA PHF12 57649 21 10 65

Total number of gains: 101; Total number of losses: 26; Total Number of normals: 361.  

 

Somatic mutations of PHF12:

 

Generating mutation plots.

 

Highly correlated genes for PHF12:

 

Showing top 20/150 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PHF12C19orf570.80442303
PHF12CUEDC10.774623303
PHF12NCCRP10.770739303
PHF12HOXC90.765367404
PHF12TMPRSS11A0.760643303
PHF12TRAF40.742519505
PHF12KRTAP20-10.738397303
PHF12IPO90.731108404
PHF12ARID4B0.722282303
PHF12OR5AS10.713505303
PHF12TAF5L0.711366403
PHF12FBRSL10.711201404
PHF12C1orf870.709394404
PHF12SFI10.693731504
PHF12OTOP30.691074303
PHF12SFXN30.689451504
PHF12TIMMDC10.684649403
PHF12ATP2A30.684356303
PHF12KPRP0.684132303
PHF12ZNF5670.683814303

For details and further investigation, click here