| Full name: glutamate-ammonia ligase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 2752 | HGNC ID: HGNC:4341 | Ensembl Gene: ENSG00000135821 | OMIM ID: 138290 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GLUL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLUL | 2752 | 215001_s_at | 0.0094 | 0.9882 | |
| GSE20347 | GLUL | 2752 | 215001_s_at | 0.0066 | 0.9860 | |
| GSE23400 | GLUL | 2752 | 215001_s_at | -0.3584 | 0.0046 | |
| GSE26886 | GLUL | 2752 | 215001_s_at | -0.4749 | 0.0766 | |
| GSE29001 | GLUL | 2752 | 215001_s_at | -0.4019 | 0.1060 | |
| GSE38129 | GLUL | 2752 | 215001_s_at | -0.2607 | 0.1704 | |
| GSE45670 | GLUL | 2752 | 215001_s_at | 0.0598 | 0.8184 | |
| GSE53622 | GLUL | 2752 | 38823 | -0.7220 | 0.0000 | |
| GSE53624 | GLUL | 2752 | 38823 | -0.7045 | 0.0000 | |
| GSE63941 | GLUL | 2752 | 215001_s_at | 0.2200 | 0.8121 | |
| GSE77861 | GLUL | 2752 | 215001_s_at | -0.2225 | 0.5537 | |
| GSE97050 | GLUL | 2752 | A_24_P53976 | 0.0142 | 0.9740 | |
| SRP007169 | GLUL | 2752 | RNAseq | -1.7829 | 0.0026 | |
| SRP008496 | GLUL | 2752 | RNAseq | -1.9256 | 0.0000 | |
| SRP064894 | GLUL | 2752 | RNAseq | -1.0764 | 0.0003 | |
| SRP133303 | GLUL | 2752 | RNAseq | -0.0062 | 0.9800 | |
| SRP159526 | GLUL | 2752 | RNAseq | 0.1208 | 0.8540 | |
| SRP193095 | GLUL | 2752 | RNAseq | -0.3991 | 0.1441 | |
| SRP219564 | GLUL | 2752 | RNAseq | 0.7077 | 0.1957 | |
| TCGA | GLUL | 2752 | RNAseq | -0.3878 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by GLUL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GLUL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLUL | 2752 | 12 | 0 | 18 | |
| GSE20123 | GLUL | 2752 | 12 | 0 | 18 | |
| GSE43470 | GLUL | 2752 | 7 | 1 | 35 | |
| GSE46452 | GLUL | 2752 | 3 | 1 | 55 | |
| GSE47630 | GLUL | 2752 | 14 | 0 | 26 | |
| GSE54993 | GLUL | 2752 | 0 | 6 | 64 | |
| GSE54994 | GLUL | 2752 | 15 | 0 | 38 | |
| GSE60625 | GLUL | 2752 | 0 | 0 | 11 | |
| GSE74703 | GLUL | 2752 | 7 | 1 | 28 | |
| GSE74704 | GLUL | 2752 | 5 | 0 | 15 | |
| TCGA | GLUL | 2752 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of GLUL:
Generating mutation plots.
Highly correlated genes for GLUL:
Showing top 20/51 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLUL | TRIM44 | 0.680425 | 3 | 0 | 3 |
| GLUL | ATP9A | 0.647704 | 3 | 0 | 3 |
| GLUL | NDUFV2 | 0.641492 | 3 | 0 | 3 |
| GLUL | FGFR3 | 0.640106 | 4 | 0 | 4 |
| GLUL | KALRN | 0.623459 | 3 | 0 | 3 |
| GLUL | RAB31 | 0.618483 | 3 | 0 | 3 |
| GLUL | KHK | 0.611987 | 3 | 0 | 3 |
| GLUL | FAM122C | 0.609991 | 3 | 0 | 3 |
| GLUL | AMOTL1 | 0.608647 | 3 | 0 | 3 |
| GLUL | AKAP7 | 0.60055 | 3 | 0 | 3 |
| GLUL | CEP70 | 0.595897 | 5 | 0 | 3 |
| GLUL | NDUFB4 | 0.586723 | 4 | 0 | 3 |
| GLUL | SIRPG | 0.586015 | 3 | 0 | 3 |
| GLUL | PVRIG | 0.579667 | 3 | 0 | 3 |
| GLUL | SLC10A5 | 0.572739 | 3 | 0 | 3 |
| GLUL | ALKBH7 | 0.571823 | 3 | 0 | 3 |
| GLUL | AK3 | 0.571296 | 4 | 0 | 3 |
| GLUL | CEP112 | 0.56946 | 4 | 0 | 3 |
| GLUL | C11orf58 | 0.567192 | 4 | 0 | 3 |
| GLUL | BCL6 | 0.563383 | 4 | 0 | 3 |
For details and further investigation, click here
