| Full name: BCL6 transcription repressor | Alias Symbol: ZBTB27|LAZ3|BCL5|BCL6A | ||
| Type: protein-coding gene | Cytoband: 3q27.3 | ||
| Entrez ID: 604 | HGNC ID: HGNC:1001 | Ensembl Gene: ENSG00000113916 | OMIM ID: 109565 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
BCL6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of BCL6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCL6 | 604 | 203140_at | -0.1776 | 0.6672 | |
| GSE20347 | BCL6 | 604 | 203140_at | 1.0662 | 0.0001 | |
| GSE23400 | BCL6 | 604 | 203140_at | 0.5557 | 0.0000 | |
| GSE26886 | BCL6 | 604 | 203140_at | 0.6815 | 0.0202 | |
| GSE29001 | BCL6 | 604 | 203140_at | 0.7226 | 0.0057 | |
| GSE38129 | BCL6 | 604 | 203140_at | 0.7014 | 0.0006 | |
| GSE45670 | BCL6 | 604 | 203140_at | 0.2272 | 0.3557 | |
| GSE53622 | BCL6 | 604 | 135908 | 0.4415 | 0.0000 | |
| GSE53624 | BCL6 | 604 | 135908 | 0.2809 | 0.0000 | |
| GSE63941 | BCL6 | 604 | 203140_at | -1.7287 | 0.0074 | |
| GSE77861 | BCL6 | 604 | 203140_at | 1.0130 | 0.0179 | |
| GSE97050 | BCL6 | 604 | A_23_P57856 | -0.0173 | 0.9774 | |
| SRP007169 | BCL6 | 604 | RNAseq | 1.0587 | 0.0648 | |
| SRP008496 | BCL6 | 604 | RNAseq | 0.9230 | 0.0032 | |
| SRP064894 | BCL6 | 604 | RNAseq | 0.2479 | 0.3209 | |
| SRP133303 | BCL6 | 604 | RNAseq | 0.3633 | 0.1153 | |
| SRP159526 | BCL6 | 604 | RNAseq | 0.6389 | 0.0111 | |
| SRP193095 | BCL6 | 604 | RNAseq | 0.7455 | 0.0045 | |
| SRP219564 | BCL6 | 604 | RNAseq | 0.0886 | 0.8225 | |
| TCGA | BCL6 | 604 | RNAseq | 0.1063 | 0.1155 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by BCL6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCL6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCL6 | 604 | 24 | 0 | 6 | |
| GSE20123 | BCL6 | 604 | 24 | 0 | 6 | |
| GSE43470 | BCL6 | 604 | 23 | 1 | 19 | |
| GSE46452 | BCL6 | 604 | 19 | 1 | 39 | |
| GSE47630 | BCL6 | 604 | 27 | 2 | 11 | |
| GSE54993 | BCL6 | 604 | 1 | 19 | 50 | |
| GSE54994 | BCL6 | 604 | 40 | 0 | 13 | |
| GSE60625 | BCL6 | 604 | 0 | 6 | 5 | |
| GSE74703 | BCL6 | 604 | 20 | 1 | 15 | |
| GSE74704 | BCL6 | 604 | 16 | 0 | 4 | |
| TCGA | BCL6 | 604 | 77 | 0 | 19 |
Total number of gains: 271; Total number of losses: 30; Total Number of normals: 187.
Somatic mutations of BCL6:
Generating mutation plots.
Highly correlated genes for BCL6:
Showing top 20/499 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCL6 | SLC41A1 | 0.763018 | 3 | 0 | 3 |
| BCL6 | CKB | 0.759739 | 3 | 0 | 3 |
| BCL6 | SPOPL | 0.742279 | 3 | 0 | 3 |
| BCL6 | TRIB1 | 0.739148 | 3 | 0 | 3 |
| BCL6 | SEC23A | 0.738339 | 3 | 0 | 3 |
| BCL6 | ZCCHC17 | 0.735276 | 3 | 0 | 3 |
| BCL6 | SGIP1 | 0.732911 | 3 | 0 | 3 |
| BCL6 | ANGPT1 | 0.732156 | 3 | 0 | 3 |
| BCL6 | PCDH18 | 0.72996 | 3 | 0 | 3 |
| BCL6 | DNMBP | 0.724706 | 3 | 0 | 3 |
| BCL6 | MRGPRF | 0.722881 | 3 | 0 | 3 |
| BCL6 | ZNF540 | 0.718661 | 3 | 0 | 3 |
| BCL6 | KLHDC1 | 0.717971 | 3 | 0 | 3 |
| BCL6 | PITPNC1 | 0.713078 | 3 | 0 | 3 |
| BCL6 | SESTD1 | 0.71291 | 4 | 0 | 4 |
| BCL6 | HECTD2 | 0.712533 | 3 | 0 | 3 |
| BCL6 | PDPR | 0.707681 | 3 | 0 | 3 |
| BCL6 | INPP5B | 0.704213 | 3 | 0 | 3 |
| BCL6 | ZBTB2 | 0.702675 | 3 | 0 | 3 |
| BCL6 | EPC2 | 0.701805 | 3 | 0 | 3 |
For details and further investigation, click here
