| Full name: ketohexokinase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 3795 | HGNC ID: HGNC:6315 | Ensembl Gene: ENSG00000138030 | OMIM ID: 614058 |
| Drug and gene relationship at DGIdb | |||
Expression of KHK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KHK | 3795 | 211028_s_at | 0.1922 | 0.4975 | |
| GSE20347 | KHK | 3795 | 211028_s_at | 0.1931 | 0.0489 | |
| GSE23400 | KHK | 3795 | 211028_s_at | -0.1617 | 0.0013 | |
| GSE26886 | KHK | 3795 | 211028_s_at | 0.1592 | 0.2458 | |
| GSE29001 | KHK | 3795 | 211028_s_at | 0.2321 | 0.2269 | |
| GSE38129 | KHK | 3795 | 211028_s_at | 0.1409 | 0.1704 | |
| GSE45670 | KHK | 3795 | 211028_s_at | 0.1630 | 0.1620 | |
| GSE63941 | KHK | 3795 | 211028_s_at | 0.6370 | 0.0810 | |
| GSE77861 | KHK | 3795 | 211028_s_at | -0.0226 | 0.8628 | |
| GSE97050 | KHK | 3795 | A_33_P3309984 | -0.0387 | 0.9128 | |
| SRP007169 | KHK | 3795 | RNAseq | -0.0588 | 0.9302 | |
| SRP064894 | KHK | 3795 | RNAseq | 0.6273 | 0.1063 | |
| SRP133303 | KHK | 3795 | RNAseq | -0.0400 | 0.8923 | |
| SRP159526 | KHK | 3795 | RNAseq | 1.3534 | 0.0020 | |
| SRP193095 | KHK | 3795 | RNAseq | 0.2430 | 0.3600 | |
| SRP219564 | KHK | 3795 | RNAseq | 0.4295 | 0.4268 | |
| TCGA | KHK | 3795 | RNAseq | 0.0085 | 0.9569 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KHK expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KHK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KHK | 3795 | 11 | 2 | 17 | |
| GSE20123 | KHK | 3795 | 11 | 2 | 17 | |
| GSE43470 | KHK | 3795 | 3 | 1 | 39 | |
| GSE46452 | KHK | 3795 | 3 | 4 | 52 | |
| GSE47630 | KHK | 3795 | 8 | 0 | 32 | |
| GSE54993 | KHK | 3795 | 0 | 6 | 64 | |
| GSE54994 | KHK | 3795 | 10 | 0 | 43 | |
| GSE60625 | KHK | 3795 | 0 | 3 | 8 | |
| GSE74703 | KHK | 3795 | 3 | 0 | 33 | |
| GSE74704 | KHK | 3795 | 9 | 1 | 10 | |
| TCGA | KHK | 3795 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of KHK:
Generating mutation plots.
Highly correlated genes for KHK:
Showing top 20/253 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KHK | ADI1 | 0.762862 | 4 | 0 | 4 |
| KHK | DHFR | 0.739369 | 3 | 0 | 3 |
| KHK | SAAL1 | 0.728189 | 3 | 0 | 3 |
| KHK | MAP2K6 | 0.723178 | 3 | 0 | 3 |
| KHK | FZR1 | 0.718195 | 3 | 0 | 3 |
| KHK | ZNF142 | 0.717911 | 3 | 0 | 3 |
| KHK | WDR89 | 0.712171 | 3 | 0 | 3 |
| KHK | SLC39A1 | 0.698746 | 4 | 0 | 4 |
| KHK | TYSND1 | 0.697122 | 3 | 0 | 3 |
| KHK | KIAA1257 | 0.689942 | 3 | 0 | 3 |
| KHK | VEGFB | 0.68872 | 3 | 0 | 3 |
| KHK | TEX264 | 0.688699 | 3 | 0 | 3 |
| KHK | EIF4H | 0.685068 | 3 | 0 | 3 |
| KHK | SLCO3A1 | 0.681051 | 3 | 0 | 3 |
| KHK | NUDT11 | 0.680249 | 3 | 0 | 3 |
| KHK | CDAN1 | 0.67455 | 3 | 0 | 3 |
| KHK | HKDC1 | 0.673302 | 4 | 0 | 3 |
| KHK | B3GNT4 | 0.664837 | 4 | 0 | 3 |
| KHK | PSPC1 | 0.664701 | 3 | 0 | 3 |
| KHK | CEP192 | 0.656718 | 4 | 0 | 3 |
For details and further investigation, click here
