FGFR3

 

Full name: fibroblast growth factor receptor 3 Alias Symbol: CEK2|JTK4|CD333
Type: protein-coding gene Cytoband: 4p16.3
Entrez ID: 2261 HGNC ID: HGNC:3690 Ensembl Gene: ENSG00000068078 OMIM ID: 134934
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

FGFR3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05219Bladder cancer

 

Expression of FGFR3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FGFR3 2261 204379_s_at 0.7849 0.2710
GSE20347 FGFR3 2261 204379_s_at -0.5863 0.1451
GSE23400 FGFR3 2261 204379_s_at -0.3182 0.1110
GSE26886 FGFR3 2261 204379_s_at -0.5159 0.0442
GSE29001 FGFR3 2261 204379_s_at -0.3259 0.3307
GSE38129 FGFR3 2261 204379_s_at 0.1320 0.8220
GSE45670 FGFR3 2261 204379_s_at 0.2487 0.4989
GSE53622 FGFR3 2261 76710 -0.4050 0.1308
GSE53624 FGFR3 2261 76710 -0.7803 0.0000
GSE63941 FGFR3 2261 204379_s_at 3.0089 0.0182
GSE77861 FGFR3 2261 204379_s_at -0.3907 0.4471
GSE97050 FGFR3 2261 A_23_P212830 0.0069 0.9760
SRP007169 FGFR3 2261 RNAseq -0.6261 0.2076
SRP008496 FGFR3 2261 RNAseq -0.8919 0.0121
SRP064894 FGFR3 2261 RNAseq -1.2831 0.0002
SRP133303 FGFR3 2261 RNAseq -0.8881 0.0002
SRP159526 FGFR3 2261 RNAseq -1.0498 0.0950
SRP193095 FGFR3 2261 RNAseq -0.5341 0.0694
SRP219564 FGFR3 2261 RNAseq -1.4092 0.2028
TCGA FGFR3 2261 RNAseq 0.5901 0.0000

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by FGFR3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FGFR3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FGFR3 2261 0 16 14
GSE20123 FGFR3 2261 0 16 14
GSE43470 FGFR3 2261 1 16 26
GSE46452 FGFR3 2261 1 36 22
GSE47630 FGFR3 2261 2 19 19
GSE54993 FGFR3 2261 11 0 59
GSE54994 FGFR3 2261 3 12 38
GSE60625 FGFR3 2261 0 0 11
GSE74703 FGFR3 2261 1 12 23
GSE74704 FGFR3 2261 0 8 12
TCGA FGFR3 2261 9 47 40

Total number of gains: 28; Total number of losses: 182; Total Number of normals: 278.  

 

Somatic mutations of FGFR3:

 

Generating mutation plots.

 

Highly correlated genes for FGFR3:

 

Showing top 20/551 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FGFR3STARD100.733371404
FGFR3SLC25A430.72638303
FGFR3HMGN30.717109303
FGFR3DUSP230.714383404
FGFR3FAM83C0.702519505
FGFR3CKMT1A0.702242303
FGFR3F11R0.697967505
FGFR3DDX230.694145303
FGFR3RAP2B0.693809303
FGFR3SLC9A3R10.6876141009
FGFR3AMMECR10.683199605
FGFR3F2RL10.679232303
FGFR3FCF10.677166403
FGFR3KIAA15220.673482605
FGFR3GTF2IRD10.672447504
FGFR3TADA10.671784303
FGFR3CHMP4C0.668507604
FGFR3KCTD10.668274403
FGFR3NIPBL0.667993403
FGFR3JUP0.666995908

For details and further investigation, click here