GNAS

 

Full name: GNAS complex locus Alias Symbol: NESP55|NESP|GNASXL|GPSA|SCG6|SgVI
Type: protein-coding gene Cytoband: 20q13.32
Entrez ID: 2778 HGNC ID: HGNC:4392 Ensembl Gene: ENSG00000087460 OMIM ID: 139320
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

GNAS involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04724Glutamatergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05034Alcoholism
hsa05110Vibrio cholerae infection
hsa05142Chagas disease (American trypanosomiasis)

 

Expression of GNAS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNAS 2778 200780_x_at 0.2660 0.3470
GSE20347 GNAS 2778 200780_x_at -0.1194 0.3405
GSE23400 GNAS 2778 214548_x_at 0.0646 0.2910
GSE26886 GNAS 2778 200780_x_at 0.2869 0.1283
GSE29001 GNAS 2778 200981_x_at -0.0679 0.8706
GSE38129 GNAS 2778 200780_x_at -0.0541 0.6420
GSE45670 GNAS 2778 200780_x_at -0.2401 0.0092
GSE53622 GNAS 2778 47139 0.2321 0.0008
GSE53624 GNAS 2778 47139 0.1356 0.0059
GSE63941 GNAS 2778 200780_x_at 0.5530 0.1165
GSE77861 GNAS 2778 200780_x_at -0.2777 0.2088
GSE97050 GNAS 2778 A_24_P418809 -0.0590 0.8390
SRP007169 GNAS 2778 RNAseq -1.1413 0.0065
SRP008496 GNAS 2778 RNAseq -0.9067 0.0001
SRP064894 GNAS 2778 RNAseq -0.0779 0.7032
SRP133303 GNAS 2778 RNAseq -0.1408 0.2685
SRP159526 GNAS 2778 RNAseq 0.5932 0.1894
SRP193095 GNAS 2778 RNAseq -0.3455 0.0013
SRP219564 GNAS 2778 RNAseq -0.1980 0.6462
TCGA GNAS 2778 RNAseq -0.0230 0.5056

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by GNAS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNAS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNAS 2778 14 2 14
GSE20123 GNAS 2778 14 2 14
GSE43470 GNAS 2778 13 0 30
GSE46452 GNAS 2778 29 0 30
GSE47630 GNAS 2778 24 1 15
GSE54993 GNAS 2778 0 17 53
GSE54994 GNAS 2778 29 0 24
GSE60625 GNAS 2778 0 0 11
GSE74703 GNAS 2778 11 0 25
GSE74704 GNAS 2778 11 0 9
TCGA GNAS 2778 43 4 49

Total number of gains: 188; Total number of losses: 26; Total Number of normals: 274.  

 

Somatic mutations of GNAS:

 

Generating mutation plots.

 

Highly correlated genes for GNAS:

 

Showing top 20/171 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNASHDAC60.771656303
GNASZNF2130.764352303
GNASZGPAT0.730959505
GNASNGF0.71844303
GNASPOLR2L0.715665303
GNASXRRA10.709579303
GNASPYGO10.708218303
GNASC1orf350.706573303
GNASPIP4K2B0.706151303
GNASGALM0.694426303
GNASGUSB0.692154303
GNASBCL9L0.688437303
GNASACIN10.677257303
GNASRRM2B0.664406303
GNASMRPL550.662041303
GNASMED250.658765303
GNASMAF10.650356403
GNASROGDI0.647835303
GNASMED290.645136303
GNASZNF5030.641402404

For details and further investigation, click here