| Full name: MAF1 homolog, negative regulator of RNA polymerase III | Alias Symbol: DKFZp586G1123 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 84232 | HGNC ID: HGNC:24966 | Ensembl Gene: ENSG00000179632 | OMIM ID: 610210 |
| Drug and gene relationship at DGIdb | |||
Expression of MAF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAF1 | 84232 | 222998_at | 0.6234 | 0.2653 | |
| GSE26886 | MAF1 | 84232 | 222998_at | 0.9499 | 0.0002 | |
| GSE45670 | MAF1 | 84232 | 222998_at | 0.2109 | 0.1157 | |
| GSE53622 | MAF1 | 84232 | 110134 | 0.0763 | 0.2457 | |
| GSE53624 | MAF1 | 84232 | 110134 | 0.1806 | 0.0077 | |
| GSE63941 | MAF1 | 84232 | 222998_at | 1.7215 | 0.0022 | |
| GSE77861 | MAF1 | 84232 | 222998_at | 0.4499 | 0.0786 | |
| GSE97050 | MAF1 | 84232 | A_23_P33072 | -0.4563 | 0.3252 | |
| SRP007169 | MAF1 | 84232 | RNAseq | -0.3787 | 0.2418 | |
| SRP008496 | MAF1 | 84232 | RNAseq | -0.0612 | 0.7945 | |
| SRP064894 | MAF1 | 84232 | RNAseq | 0.6093 | 0.0480 | |
| SRP133303 | MAF1 | 84232 | RNAseq | 0.2847 | 0.0559 | |
| SRP159526 | MAF1 | 84232 | RNAseq | 0.2104 | 0.1711 | |
| SRP193095 | MAF1 | 84232 | RNAseq | 0.2798 | 0.0249 | |
| SRP219564 | MAF1 | 84232 | RNAseq | -0.0951 | 0.8497 | |
| TCGA | MAF1 | 84232 | RNAseq | 0.0257 | 0.5874 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MAF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAF1 | 84232 | 17 | 1 | 12 | |
| GSE20123 | MAF1 | 84232 | 17 | 1 | 12 | |
| GSE43470 | MAF1 | 84232 | 16 | 2 | 25 | |
| GSE46452 | MAF1 | 84232 | 27 | 0 | 32 | |
| GSE47630 | MAF1 | 84232 | 23 | 1 | 16 | |
| GSE54993 | MAF1 | 84232 | 0 | 25 | 45 | |
| GSE54994 | MAF1 | 84232 | 39 | 1 | 13 | |
| GSE60625 | MAF1 | 84232 | 3 | 4 | 4 | |
| GSE74703 | MAF1 | 84232 | 14 | 1 | 21 | |
| GSE74704 | MAF1 | 84232 | 10 | 0 | 10 | |
| TCGA | MAF1 | 84232 | 63 | 2 | 31 |
Total number of gains: 229; Total number of losses: 38; Total Number of normals: 221.
Somatic mutations of MAF1:
Generating mutation plots.
Highly correlated genes for MAF1:
Showing top 20/870 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAF1 | JRK | 0.740807 | 3 | 0 | 3 |
| MAF1 | ZNF496 | 0.740527 | 4 | 0 | 4 |
| MAF1 | SMG5 | 0.735783 | 3 | 0 | 3 |
| MAF1 | CHODL | 0.72806 | 3 | 0 | 3 |
| MAF1 | ASMTL | 0.723721 | 3 | 0 | 3 |
| MAF1 | NCOR2 | 0.713963 | 4 | 0 | 4 |
| MAF1 | MAP1B | 0.703889 | 3 | 0 | 3 |
| MAF1 | SPTAN1 | 0.693996 | 3 | 0 | 3 |
| MAF1 | EEF2 | 0.692827 | 4 | 0 | 3 |
| MAF1 | TOP1MT | 0.684181 | 5 | 0 | 5 |
| MAF1 | CHAF1A | 0.68272 | 4 | 0 | 4 |
| MAF1 | HSF1 | 0.681885 | 9 | 0 | 7 |
| MAF1 | NAT9 | 0.681325 | 3 | 0 | 3 |
| MAF1 | RPL8 | 0.678534 | 7 | 0 | 6 |
| MAF1 | GPX4 | 0.677877 | 5 | 0 | 5 |
| MAF1 | POLR3K | 0.67468 | 3 | 0 | 3 |
| MAF1 | GGPS1 | 0.672945 | 3 | 0 | 3 |
| MAF1 | CACTIN | 0.672747 | 5 | 0 | 4 |
| MAF1 | GTPBP6 | 0.67226 | 4 | 0 | 4 |
| MAF1 | ANP32B | 0.672259 | 5 | 0 | 4 |
For details and further investigation, click here
