| Full name: RNA polymerase II subunit L | Alias Symbol: RPB10beta|RBP10|RPABC5|RPB7.6|hRPB7.6|hsRPB10b | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 5441 | HGNC ID: HGNC:9199 | Ensembl Gene: ENSG00000177700 | OMIM ID: 601189 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR2L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR2L | 5441 | 211730_s_at | -0.1828 | 0.6256 | |
| GSE20347 | POLR2L | 5441 | 211730_s_at | -0.6905 | 0.0000 | |
| GSE23400 | POLR2L | 5441 | 211730_s_at | -0.1620 | 0.0582 | |
| GSE26886 | POLR2L | 5441 | 211730_s_at | 0.2762 | 0.2533 | |
| GSE29001 | POLR2L | 5441 | 211730_s_at | -0.4927 | 0.2979 | |
| GSE38129 | POLR2L | 5441 | 211730_s_at | -0.4676 | 0.0006 | |
| GSE45670 | POLR2L | 5441 | 211730_s_at | -0.0594 | 0.7266 | |
| GSE63941 | POLR2L | 5441 | 211730_s_at | -1.1068 | 0.0889 | |
| GSE77861 | POLR2L | 5441 | 211730_s_at | -0.5744 | 0.0974 | |
| GSE97050 | POLR2L | 5441 | A_23_P33022 | -0.0760 | 0.7683 | |
| SRP007169 | POLR2L | 5441 | RNAseq | -1.2890 | 0.0006 | |
| SRP008496 | POLR2L | 5441 | RNAseq | -0.9685 | 0.0003 | |
| SRP064894 | POLR2L | 5441 | RNAseq | 0.3722 | 0.3919 | |
| SRP133303 | POLR2L | 5441 | RNAseq | -0.2569 | 0.0824 | |
| SRP159526 | POLR2L | 5441 | RNAseq | -0.2483 | 0.4785 | |
| SRP193095 | POLR2L | 5441 | RNAseq | -0.5836 | 0.0004 | |
| SRP219564 | POLR2L | 5441 | RNAseq | -0.4660 | 0.1180 | |
| TCGA | POLR2L | 5441 | RNAseq | 0.0628 | 0.3503 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by POLR2L expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of POLR2L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR2L | 5441 | 1 | 11 | 18 | |
| GSE20123 | POLR2L | 5441 | 1 | 12 | 17 | |
| GSE43470 | POLR2L | 5441 | 1 | 10 | 32 | |
| GSE46452 | POLR2L | 5441 | 7 | 8 | 44 | |
| GSE47630 | POLR2L | 5441 | 4 | 12 | 24 | |
| GSE54993 | POLR2L | 5441 | 3 | 1 | 66 | |
| GSE54994 | POLR2L | 5441 | 1 | 12 | 40 | |
| GSE60625 | POLR2L | 5441 | 0 | 0 | 11 | |
| GSE74703 | POLR2L | 5441 | 1 | 8 | 27 | |
| GSE74704 | POLR2L | 5441 | 0 | 8 | 12 | |
| TCGA | POLR2L | 5441 | 8 | 38 | 50 |
Total number of gains: 27; Total number of losses: 120; Total Number of normals: 341.
Somatic mutations of POLR2L:
Generating mutation plots.
Highly correlated genes for POLR2L:
Showing top 20/513 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR2L | SSBP1 | 0.838274 | 3 | 0 | 3 |
| POLR2L | CCDC12 | 0.768872 | 3 | 0 | 3 |
| POLR2L | PODN | 0.767852 | 3 | 0 | 3 |
| POLR2L | COMTD1 | 0.765841 | 3 | 0 | 3 |
| POLR2L | GSPT2 | 0.758669 | 3 | 0 | 3 |
| POLR2L | SYNE1 | 0.751415 | 3 | 0 | 3 |
| POLR2L | NAA60 | 0.750849 | 3 | 0 | 3 |
| POLR2L | ZNF717 | 0.747261 | 4 | 0 | 3 |
| POLR2L | PLCD3 | 0.746647 | 3 | 0 | 3 |
| POLR2L | SLC25A3 | 0.739555 | 4 | 0 | 4 |
| POLR2L | PDCD7 | 0.733408 | 3 | 0 | 3 |
| POLR2L | LYRM1 | 0.732634 | 3 | 0 | 3 |
| POLR2L | NDUFA13 | 0.730646 | 6 | 0 | 6 |
| POLR2L | MBNL3 | 0.722951 | 3 | 0 | 3 |
| POLR2L | THUMPD3 | 0.719397 | 3 | 0 | 3 |
| POLR2L | GNAS | 0.715665 | 3 | 0 | 3 |
| POLR2L | RBPJL | 0.714889 | 4 | 0 | 3 |
| POLR2L | PRADC1 | 0.711311 | 4 | 0 | 3 |
| POLR2L | CLCC1 | 0.711126 | 3 | 0 | 3 |
| POLR2L | CST5 | 0.707004 | 3 | 0 | 3 |
For details and further investigation, click here
