GNB4

 

Full name: G protein subunit beta 4 Alias Symbol: 
Type: protein-coding gene Cytoband: 3q26.33
Entrez ID: 59345 HGNC ID: HGNC:20731 Ensembl Gene: ENSG00000114450 OMIM ID: 610863
Drug and gene relationship at DGIdb

 

GNB4 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNB4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNB4 59345 225710_at -0.0700 0.9142
GSE26886 GNB4 59345 225710_at -0.2185 0.5201
GSE45670 GNB4 59345 225710_at -0.5025 0.1160
GSE63941 GNB4 59345 225710_at -1.8313 0.1673
GSE77861 GNB4 59345 225710_at -0.4357 0.5052
GSE97050 GNB4 59345 A_32_P171313 -0.5165 0.1204
SRP007169 GNB4 59345 RNAseq 2.4255 0.0050
SRP008496 GNB4 59345 RNAseq 1.8113 0.0049
SRP064894 GNB4 59345 RNAseq 0.6697 0.0043
SRP133303 GNB4 59345 RNAseq 0.8828 0.0001
SRP159526 GNB4 59345 RNAseq 0.3611 0.1054
SRP193095 GNB4 59345 RNAseq 0.4558 0.0134
SRP219564 GNB4 59345 RNAseq 0.1933 0.7364
TCGA GNB4 59345 RNAseq 0.1399 0.0836

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by GNB4 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of GNB4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNB4 59345 25 0 5
GSE20123 GNB4 59345 25 0 5
GSE43470 GNB4 59345 24 0 19
GSE46452 GNB4 59345 19 1 39
GSE47630 GNB4 59345 27 2 11
GSE54993 GNB4 59345 1 18 51
GSE54994 GNB4 59345 41 0 12
GSE60625 GNB4 59345 0 6 5
GSE74703 GNB4 59345 20 0 16
GSE74704 GNB4 59345 16 0 4
TCGA GNB4 59345 78 0 18

Total number of gains: 276; Total number of losses: 27; Total Number of normals: 185.  

 

Somatic mutations of GNB4:

 

Generating mutation plots.

 

Highly correlated genes for GNB4:

 

Showing top 20/227 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNB4ERRFI10.794035303
GNB4SNX140.783637303
GNB4GPM6B0.780535303
GNB4FAM122C0.767682303
GNB4SNTB10.765315303
GNB4TOB20.748602303
GNB4CLMP0.747803404
GNB4C5orf240.744257303
GNB4SRPX0.742332303
GNB4KIF5B0.741912303
GNB4ILK0.736536303
GNB4PPP1R15B0.734933303
GNB4STARD3NL0.73371303
GNB4ME30.727444303
GNB4STX20.72395404
GNB4WBP40.722221303
GNB4OPTN0.718884303
GNB4DIS3L20.718785303
GNB4LSM110.717194403
GNB4SRSF70.714146303

For details and further investigation, click here