| Full name: syntaxin 2 | Alias Symbol: EPM | ||
| Type: protein-coding gene | Cytoband: 12q24.33 | ||
| Entrez ID: 2054 | HGNC ID: HGNC:3403 | Ensembl Gene: ENSG00000111450 | OMIM ID: 132350 |
| Drug and gene relationship at DGIdb | |||
Expression of STX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STX2 | 2054 | 213434_at | -0.0811 | 0.9204 | |
| GSE20347 | STX2 | 2054 | 213434_at | 0.4135 | 0.0039 | |
| GSE23400 | STX2 | 2054 | 213434_at | 0.1318 | 0.1096 | |
| GSE26886 | STX2 | 2054 | 213434_at | 1.0719 | 0.0000 | |
| GSE29001 | STX2 | 2054 | 213434_at | 0.4389 | 0.0192 | |
| GSE38129 | STX2 | 2054 | 213434_at | 0.0245 | 0.9178 | |
| GSE45670 | STX2 | 2054 | 213434_at | -0.2371 | 0.4112 | |
| GSE53622 | STX2 | 2054 | 88037 | 0.2174 | 0.1307 | |
| GSE53624 | STX2 | 2054 | 88037 | 0.7477 | 0.0000 | |
| GSE63941 | STX2 | 2054 | 213434_at | -2.5061 | 0.0005 | |
| GSE77861 | STX2 | 2054 | 213434_at | 0.3788 | 0.1896 | |
| GSE97050 | STX2 | 2054 | A_24_P364296 | -0.1220 | 0.6885 | |
| SRP007169 | STX2 | 2054 | RNAseq | 3.0880 | 0.0000 | |
| SRP008496 | STX2 | 2054 | RNAseq | 4.5199 | 0.0000 | |
| SRP064894 | STX2 | 2054 | RNAseq | 1.0889 | 0.0000 | |
| SRP133303 | STX2 | 2054 | RNAseq | 0.8655 | 0.0034 | |
| SRP159526 | STX2 | 2054 | RNAseq | 0.1638 | 0.5357 | |
| SRP193095 | STX2 | 2054 | RNAseq | 1.4854 | 0.0000 | |
| SRP219564 | STX2 | 2054 | RNAseq | 0.1156 | 0.8309 | |
| TCGA | STX2 | 2054 | RNAseq | -0.2332 | 0.0246 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by STX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STX2 | 2054 | 4 | 4 | 22 | |
| GSE20123 | STX2 | 2054 | 4 | 4 | 22 | |
| GSE43470 | STX2 | 2054 | 2 | 2 | 39 | |
| GSE46452 | STX2 | 2054 | 8 | 2 | 49 | |
| GSE47630 | STX2 | 2054 | 9 | 3 | 28 | |
| GSE54993 | STX2 | 2054 | 0 | 6 | 64 | |
| GSE54994 | STX2 | 2054 | 4 | 7 | 42 | |
| GSE60625 | STX2 | 2054 | 0 | 0 | 11 | |
| GSE74703 | STX2 | 2054 | 2 | 1 | 33 | |
| GSE74704 | STX2 | 2054 | 2 | 3 | 15 | |
| TCGA | STX2 | 2054 | 22 | 13 | 61 |
Total number of gains: 57; Total number of losses: 45; Total Number of normals: 386.
Somatic mutations of STX2:
Generating mutation plots.
Highly correlated genes for STX2:
Showing top 20/1362 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STX2 | TRIB1 | 0.7913 | 3 | 0 | 3 |
| STX2 | C9orf78 | 0.779656 | 3 | 0 | 3 |
| STX2 | CLMP | 0.770936 | 6 | 0 | 5 |
| STX2 | MCAM | 0.759779 | 10 | 0 | 10 |
| STX2 | MICAL2 | 0.759576 | 10 | 0 | 10 |
| STX2 | PTPN21 | 0.750823 | 3 | 0 | 3 |
| STX2 | TNFRSF19 | 0.746136 | 3 | 0 | 3 |
| STX2 | FNIP2 | 0.746067 | 4 | 0 | 4 |
| STX2 | NPHP3 | 0.741753 | 3 | 0 | 3 |
| STX2 | SLC38A10 | 0.740494 | 3 | 0 | 3 |
| STX2 | PELI2 | 0.730114 | 3 | 0 | 3 |
| STX2 | TK2 | 0.725929 | 3 | 0 | 3 |
| STX2 | GNB4 | 0.72395 | 4 | 0 | 4 |
| STX2 | RILPL1 | 0.722041 | 4 | 0 | 3 |
| STX2 | CLIC4 | 0.720577 | 12 | 0 | 10 |
| STX2 | RSPH9 | 0.719773 | 4 | 0 | 4 |
| STX2 | KCNJ8 | 0.71803 | 9 | 0 | 9 |
| STX2 | LAMA4 | 0.716353 | 12 | 0 | 11 |
| STX2 | MAP4 | 0.715756 | 5 | 0 | 5 |
| STX2 | SGTB | 0.713876 | 6 | 0 | 6 |
For details and further investigation, click here
