| Full name: malic enzyme 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q14.2 | ||
| Entrez ID: 10873 | HGNC ID: HGNC:6985 | Ensembl Gene: ENSG00000151376 | OMIM ID: 604626 |
| Drug and gene relationship at DGIdb | |||
Expression of ME3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ME3 | 10873 | 204663_at | -0.1327 | 0.7111 | |
| GSE20347 | ME3 | 10873 | 204663_at | 0.0307 | 0.9040 | |
| GSE23400 | ME3 | 10873 | 204663_at | -0.1418 | 0.0167 | |
| GSE26886 | ME3 | 10873 | 204663_at | 0.0750 | 0.6870 | |
| GSE29001 | ME3 | 10873 | 204663_at | -0.2342 | 0.1851 | |
| GSE38129 | ME3 | 10873 | 204663_at | -0.3259 | 0.1542 | |
| GSE45670 | ME3 | 10873 | 204663_at | -0.6245 | 0.0004 | |
| GSE53622 | ME3 | 10873 | 83468 | -0.8380 | 0.0000 | |
| GSE53624 | ME3 | 10873 | 32421 | -0.6631 | 0.0000 | |
| GSE63941 | ME3 | 10873 | 204663_at | -1.7487 | 0.0086 | |
| GSE77861 | ME3 | 10873 | 204663_at | -0.0496 | 0.7197 | |
| GSE97050 | ME3 | 10873 | A_23_P105227 | -0.1277 | 0.6129 | |
| SRP064894 | ME3 | 10873 | RNAseq | 0.6278 | 0.1095 | |
| SRP133303 | ME3 | 10873 | RNAseq | -0.6834 | 0.0179 | |
| SRP159526 | ME3 | 10873 | RNAseq | -0.3863 | 0.3487 | |
| SRP193095 | ME3 | 10873 | RNAseq | -0.0125 | 0.9717 | |
| SRP219564 | ME3 | 10873 | RNAseq | -0.6141 | 0.4207 | |
| TCGA | ME3 | 10873 | RNAseq | -1.4487 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ME3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ME3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ME3 | 10873 | 4 | 9 | 17 | |
| GSE20123 | ME3 | 10873 | 4 | 9 | 17 | |
| GSE43470 | ME3 | 10873 | 3 | 4 | 36 | |
| GSE46452 | ME3 | 10873 | 5 | 24 | 30 | |
| GSE47630 | ME3 | 10873 | 2 | 19 | 19 | |
| GSE54993 | ME3 | 10873 | 8 | 2 | 60 | |
| GSE54994 | ME3 | 10873 | 5 | 20 | 28 | |
| GSE60625 | ME3 | 10873 | 0 | 3 | 8 | |
| GSE74703 | ME3 | 10873 | 2 | 3 | 31 | |
| GSE74704 | ME3 | 10873 | 3 | 6 | 11 | |
| TCGA | ME3 | 10873 | 16 | 37 | 43 |
Total number of gains: 52; Total number of losses: 136; Total Number of normals: 300.
Somatic mutations of ME3:
Generating mutation plots.
Highly correlated genes for ME3:
Showing top 20/636 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ME3 | PPP2CB | 0.755494 | 3 | 0 | 3 |
| ME3 | MICA | 0.731249 | 3 | 0 | 3 |
| ME3 | GNB4 | 0.727444 | 3 | 0 | 3 |
| ME3 | TMEM132C | 0.711104 | 3 | 0 | 3 |
| ME3 | CLMP | 0.702384 | 3 | 0 | 3 |
| ME3 | ZFY | 0.700038 | 3 | 0 | 3 |
| ME3 | FBXL3 | 0.697864 | 3 | 0 | 3 |
| ME3 | DNAJC1 | 0.695887 | 4 | 0 | 4 |
| ME3 | ZNF583 | 0.694872 | 4 | 0 | 4 |
| ME3 | RBM20 | 0.691593 | 3 | 0 | 3 |
| ME3 | GABBR1 | 0.683556 | 4 | 0 | 4 |
| ME3 | A2M-AS1 | 0.683092 | 3 | 0 | 3 |
| ME3 | UBXN10 | 0.680854 | 4 | 0 | 4 |
| ME3 | TUBG2 | 0.679521 | 3 | 0 | 3 |
| ME3 | ABL1 | 0.67691 | 4 | 0 | 3 |
| ME3 | HABP4 | 0.676456 | 6 | 0 | 5 |
| ME3 | CC2D2A | 0.675112 | 3 | 0 | 3 |
| ME3 | ELF2 | 0.672337 | 4 | 0 | 3 |
| ME3 | CLCC1 | 0.670881 | 4 | 0 | 4 |
| ME3 | PDCD4 | 0.669262 | 3 | 0 | 3 |
For details and further investigation, click here
