| Full name: transducer of ERBB2, 2 | Alias Symbol: TOBL|TOB4|bK223H9|APRO5 | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 10766 | HGNC ID: HGNC:11980 | Ensembl Gene: ENSG00000183864 | OMIM ID: 607396 |
| Drug and gene relationship at DGIdb | |||
Expression of TOB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOB2 | 10766 | 222243_s_at | -0.3756 | 0.6176 | |
| GSE20347 | TOB2 | 10766 | 222243_s_at | -0.1064 | 0.5034 | |
| GSE23400 | TOB2 | 10766 | 221496_s_at | -0.1434 | 0.1572 | |
| GSE26886 | TOB2 | 10766 | 222243_s_at | 0.0200 | 0.9408 | |
| GSE29001 | TOB2 | 10766 | 222243_s_at | 0.1572 | 0.5663 | |
| GSE38129 | TOB2 | 10766 | 222243_s_at | -0.4028 | 0.0049 | |
| GSE45670 | TOB2 | 10766 | 222243_s_at | -0.1232 | 0.4449 | |
| GSE63941 | TOB2 | 10766 | 222243_s_at | -0.9721 | 0.0137 | |
| GSE77861 | TOB2 | 10766 | 222243_s_at | 0.0051 | 0.9892 | |
| GSE97050 | TOB2 | 10766 | A_32_P179676 | -0.8160 | 0.0887 | |
| SRP007169 | TOB2 | 10766 | RNAseq | -0.4486 | 0.1470 | |
| SRP008496 | TOB2 | 10766 | RNAseq | -0.2486 | 0.2806 | |
| SRP064894 | TOB2 | 10766 | RNAseq | -0.1368 | 0.3757 | |
| SRP133303 | TOB2 | 10766 | RNAseq | -0.3605 | 0.0106 | |
| SRP159526 | TOB2 | 10766 | RNAseq | -0.4018 | 0.1343 | |
| SRP193095 | TOB2 | 10766 | RNAseq | -0.2255 | 0.0388 | |
| SRP219564 | TOB2 | 10766 | RNAseq | -0.2182 | 0.6628 | |
| TCGA | TOB2 | 10766 | RNAseq | -0.2837 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TOB2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TOB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOB2 | 10766 | 6 | 5 | 19 | |
| GSE20123 | TOB2 | 10766 | 6 | 4 | 20 | |
| GSE43470 | TOB2 | 10766 | 5 | 6 | 32 | |
| GSE46452 | TOB2 | 10766 | 31 | 2 | 26 | |
| GSE47630 | TOB2 | 10766 | 9 | 4 | 27 | |
| GSE54993 | TOB2 | 10766 | 3 | 6 | 61 | |
| GSE54994 | TOB2 | 10766 | 11 | 8 | 34 | |
| GSE60625 | TOB2 | 10766 | 5 | 0 | 6 | |
| GSE74703 | TOB2 | 10766 | 5 | 4 | 27 | |
| GSE74704 | TOB2 | 10766 | 3 | 2 | 15 | |
| TCGA | TOB2 | 10766 | 27 | 14 | 55 |
Total number of gains: 111; Total number of losses: 55; Total Number of normals: 322.
Somatic mutations of TOB2:
Generating mutation plots.
Highly correlated genes for TOB2:
Showing top 20/311 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOB2 | PRICKLE2 | 0.811926 | 3 | 0 | 3 |
| TOB2 | NAP1L5 | 0.79664 | 3 | 0 | 3 |
| TOB2 | CD99L2 | 0.769765 | 3 | 0 | 3 |
| TOB2 | ZNF208 | 0.761902 | 3 | 0 | 3 |
| TOB2 | PTPN21 | 0.761529 | 3 | 0 | 3 |
| TOB2 | C20orf194 | 0.751437 | 3 | 0 | 3 |
| TOB2 | GNB4 | 0.748602 | 3 | 0 | 3 |
| TOB2 | SGCB | 0.746179 | 3 | 0 | 3 |
| TOB2 | HMCN1 | 0.746105 | 3 | 0 | 3 |
| TOB2 | ZBTB26 | 0.742724 | 3 | 0 | 3 |
| TOB2 | FZD4 | 0.742685 | 3 | 0 | 3 |
| TOB2 | SOX17 | 0.736564 | 3 | 0 | 3 |
| TOB2 | FAM98B | 0.736144 | 3 | 0 | 3 |
| TOB2 | BCAS2 | 0.735158 | 3 | 0 | 3 |
| TOB2 | S1PR3 | 0.734424 | 3 | 0 | 3 |
| TOB2 | HEXIM1 | 0.730765 | 3 | 0 | 3 |
| TOB2 | ANTXR2 | 0.727541 | 3 | 0 | 3 |
| TOB2 | CDC37L1 | 0.727012 | 3 | 0 | 3 |
| TOB2 | UBE4B | 0.726858 | 3 | 0 | 3 |
| TOB2 | ANGPTL1 | 0.721321 | 3 | 0 | 3 |
For details and further investigation, click here
