| Full name: protein phosphatase 1 regulatory subunit 15B | Alias Symbol: FLJ14744 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 84919 | HGNC ID: HGNC:14951 | Ensembl Gene: ENSG00000158615 | OMIM ID: 613257 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PPP1R15B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R15B | 84919 | 224692_at | -0.1293 | 0.8040 | |
| GSE26886 | PPP1R15B | 84919 | 224692_at | -0.2733 | 0.2490 | |
| GSE45670 | PPP1R15B | 84919 | 224692_at | -0.3144 | 0.0190 | |
| GSE53622 | PPP1R15B | 84919 | 41013 | -0.5152 | 0.0000 | |
| GSE53624 | PPP1R15B | 84919 | 41013 | -0.5550 | 0.0000 | |
| GSE63941 | PPP1R15B | 84919 | 224692_at | 0.7726 | 0.0674 | |
| GSE77861 | PPP1R15B | 84919 | 224692_at | 0.0186 | 0.9470 | |
| GSE97050 | PPP1R15B | 84919 | A_33_P3386716 | -0.5998 | 0.1057 | |
| SRP007169 | PPP1R15B | 84919 | RNAseq | -0.9015 | 0.0178 | |
| SRP008496 | PPP1R15B | 84919 | RNAseq | -0.7958 | 0.0040 | |
| SRP064894 | PPP1R15B | 84919 | RNAseq | -0.6895 | 0.0016 | |
| SRP133303 | PPP1R15B | 84919 | RNAseq | -0.0341 | 0.7771 | |
| SRP159526 | PPP1R15B | 84919 | RNAseq | -0.3069 | 0.2036 | |
| SRP193095 | PPP1R15B | 84919 | RNAseq | -0.4494 | 0.0000 | |
| SRP219564 | PPP1R15B | 84919 | RNAseq | 0.0469 | 0.8800 | |
| TCGA | PPP1R15B | 84919 | RNAseq | -0.1681 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R15B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R15B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R15B | 84919 | 11 | 0 | 19 | |
| GSE20123 | PPP1R15B | 84919 | 11 | 0 | 19 | |
| GSE43470 | PPP1R15B | 84919 | 6 | 0 | 37 | |
| GSE46452 | PPP1R15B | 84919 | 3 | 1 | 55 | |
| GSE47630 | PPP1R15B | 84919 | 14 | 0 | 26 | |
| GSE54993 | PPP1R15B | 84919 | 0 | 6 | 64 | |
| GSE54994 | PPP1R15B | 84919 | 15 | 0 | 38 | |
| GSE60625 | PPP1R15B | 84919 | 0 | 0 | 11 | |
| GSE74703 | PPP1R15B | 84919 | 6 | 0 | 30 | |
| GSE74704 | PPP1R15B | 84919 | 5 | 0 | 15 | |
| TCGA | PPP1R15B | 84919 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of PPP1R15B:
Generating mutation plots.
Highly correlated genes for PPP1R15B:
Showing top 20/222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R15B | POGK | 0.773477 | 3 | 0 | 3 |
| PPP1R15B | DNAJC24 | 0.755455 | 3 | 0 | 3 |
| PPP1R15B | SLC19A2 | 0.7369 | 4 | 0 | 4 |
| PPP1R15B | GNB4 | 0.734933 | 3 | 0 | 3 |
| PPP1R15B | SENP6 | 0.730976 | 3 | 0 | 3 |
| PPP1R15B | ZNF514 | 0.722989 | 3 | 0 | 3 |
| PPP1R15B | DNTTIP2 | 0.720053 | 3 | 0 | 3 |
| PPP1R15B | IREB2 | 0.715218 | 3 | 0 | 3 |
| PPP1R15B | NRARP | 0.714301 | 3 | 0 | 3 |
| PPP1R15B | NR2C2 | 0.71298 | 3 | 0 | 3 |
| PPP1R15B | TNRC6A | 0.711138 | 3 | 0 | 3 |
| PPP1R15B | IPP | 0.709852 | 3 | 0 | 3 |
| PPP1R15B | HERPUD2 | 0.698959 | 4 | 0 | 3 |
| PPP1R15B | ZNF546 | 0.698528 | 3 | 0 | 3 |
| PPP1R15B | EIF2S2 | 0.696697 | 4 | 0 | 3 |
| PPP1R15B | C1orf56 | 0.695258 | 3 | 0 | 3 |
| PPP1R15B | FAM174A | 0.690865 | 3 | 0 | 3 |
| PPP1R15B | VPS37B | 0.686828 | 3 | 0 | 3 |
| PPP1R15B | ARL5A | 0.684717 | 3 | 0 | 3 |
| PPP1R15B | LIPT1 | 0.68443 | 3 | 0 | 3 |
For details and further investigation, click here
