| Full name: kinesin family member 5B | Alias Symbol: KNS | ||
| Type: protein-coding gene | Cytoband: 10p11.22 | ||
| Entrez ID: 3799 | HGNC ID: HGNC:6324 | Ensembl Gene: ENSG00000170759 | OMIM ID: 602809 |
| Drug and gene relationship at DGIdb | |||
KIF5B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04728 | Dopaminergic synapse |
Expression of KIF5B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIF5B | 3799 | 201991_s_at | -0.1442 | 0.7449 | |
| GSE20347 | KIF5B | 3799 | 201991_s_at | 0.0077 | 0.9645 | |
| GSE23400 | KIF5B | 3799 | 201991_s_at | 0.1366 | 0.1818 | |
| GSE26886 | KIF5B | 3799 | 201991_s_at | 0.2604 | 0.2627 | |
| GSE29001 | KIF5B | 3799 | 201991_s_at | -0.1714 | 0.4170 | |
| GSE38129 | KIF5B | 3799 | 201991_s_at | -0.1702 | 0.2838 | |
| GSE45670 | KIF5B | 3799 | 201991_s_at | 0.0679 | 0.6344 | |
| GSE53622 | KIF5B | 3799 | 10179 | -0.1371 | 0.1034 | |
| GSE53624 | KIF5B | 3799 | 59967 | -0.1117 | 0.0151 | |
| GSE63941 | KIF5B | 3799 | 201991_s_at | 0.2967 | 0.6165 | |
| GSE77861 | KIF5B | 3799 | 201991_s_at | 0.4228 | 0.0779 | |
| GSE97050 | KIF5B | 3799 | A_33_P3292337 | -0.2923 | 0.2839 | |
| SRP007169 | KIF5B | 3799 | RNAseq | 0.8513 | 0.0120 | |
| SRP008496 | KIF5B | 3799 | RNAseq | 0.9551 | 0.0000 | |
| SRP064894 | KIF5B | 3799 | RNAseq | -0.0246 | 0.8989 | |
| SRP133303 | KIF5B | 3799 | RNAseq | 0.2791 | 0.0776 | |
| SRP159526 | KIF5B | 3799 | RNAseq | -0.3142 | 0.3611 | |
| SRP193095 | KIF5B | 3799 | RNAseq | 0.0195 | 0.8521 | |
| SRP219564 | KIF5B | 3799 | RNAseq | -0.6694 | 0.2170 | |
| TCGA | KIF5B | 3799 | RNAseq | -0.1117 | 0.0235 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KIF5B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIF5B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIF5B | 3799 | 5 | 7 | 18 | |
| GSE20123 | KIF5B | 3799 | 5 | 6 | 19 | |
| GSE43470 | KIF5B | 3799 | 4 | 3 | 36 | |
| GSE46452 | KIF5B | 3799 | 1 | 14 | 44 | |
| GSE47630 | KIF5B | 3799 | 5 | 15 | 20 | |
| GSE54993 | KIF5B | 3799 | 9 | 0 | 61 | |
| GSE54994 | KIF5B | 3799 | 3 | 8 | 42 | |
| GSE60625 | KIF5B | 3799 | 0 | 0 | 11 | |
| GSE74703 | KIF5B | 3799 | 2 | 2 | 32 | |
| GSE74704 | KIF5B | 3799 | 0 | 5 | 15 | |
| TCGA | KIF5B | 3799 | 18 | 24 | 54 |
Total number of gains: 52; Total number of losses: 84; Total Number of normals: 352.
Somatic mutations of KIF5B:
Generating mutation plots.
Highly correlated genes for KIF5B:
Showing top 20/216 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIF5B | C20orf194 | 0.795698 | 3 | 0 | 3 |
| KIF5B | UBE2Q2 | 0.753641 | 3 | 0 | 3 |
| KIF5B | NKIRAS1 | 0.746745 | 3 | 0 | 3 |
| KIF5B | FAN1 | 0.746002 | 3 | 0 | 3 |
| KIF5B | GNB4 | 0.741912 | 3 | 0 | 3 |
| KIF5B | ARRDC4 | 0.740976 | 3 | 0 | 3 |
| KIF5B | IRF2BP2 | 0.726992 | 3 | 0 | 3 |
| KIF5B | MCAM | 0.724377 | 3 | 0 | 3 |
| KIF5B | PCGF6 | 0.703027 | 3 | 0 | 3 |
| KIF5B | CBFA2T2 | 0.699027 | 3 | 0 | 3 |
| KIF5B | PRKAB2 | 0.694616 | 3 | 0 | 3 |
| KIF5B | ZBTB38 | 0.692776 | 3 | 0 | 3 |
| KIF5B | RYBP | 0.692772 | 4 | 0 | 4 |
| KIF5B | THOC2 | 0.69061 | 4 | 0 | 3 |
| KIF5B | ROCK2 | 0.689511 | 4 | 0 | 3 |
| KIF5B | SFSWAP | 0.684458 | 3 | 0 | 3 |
| KIF5B | PHYH | 0.683316 | 5 | 0 | 5 |
| KIF5B | SEC63 | 0.681217 | 3 | 0 | 3 |
| KIF5B | HAGH | 0.680563 | 3 | 0 | 3 |
| KIF5B | TOR1AIP1 | 0.675651 | 4 | 0 | 3 |
For details and further investigation, click here
