| Full name: protein phosphatase 6 regulatory subunit 1 | Alias Symbol: SAP190 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 22870 | HGNC ID: HGNC:29195 | Ensembl Gene: ENSG00000105063 | OMIM ID: 610875 |
| Drug and gene relationship at DGIdb | |||
Expression of PPP6R1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP6R1 | 22870 | 209229_s_at | 0.5396 | 0.2180 | |
| GSE20347 | PPP6R1 | 22870 | 209229_s_at | 0.2627 | 0.0180 | |
| GSE23400 | PPP6R1 | 22870 | 209229_s_at | 0.1612 | 0.0014 | |
| GSE26886 | PPP6R1 | 22870 | 209229_s_at | 0.5425 | 0.0000 | |
| GSE29001 | PPP6R1 | 22870 | 209229_s_at | 0.1948 | 0.2721 | |
| GSE38129 | PPP6R1 | 22870 | 209229_s_at | 0.2735 | 0.0064 | |
| GSE45670 | PPP6R1 | 22870 | 209229_s_at | 0.4100 | 0.0001 | |
| GSE63941 | PPP6R1 | 22870 | 209229_s_at | -0.0750 | 0.8269 | |
| GSE77861 | PPP6R1 | 22870 | 209229_s_at | 0.0841 | 0.6530 | |
| GSE97050 | PPP6R1 | 22870 | A_23_P119448 | 0.2315 | 0.2740 | |
| SRP007169 | PPP6R1 | 22870 | RNAseq | 0.1221 | 0.7751 | |
| SRP008496 | PPP6R1 | 22870 | RNAseq | -0.0805 | 0.7545 | |
| SRP064894 | PPP6R1 | 22870 | RNAseq | 0.2395 | 0.1411 | |
| SRP133303 | PPP6R1 | 22870 | RNAseq | 0.3990 | 0.0530 | |
| SRP159526 | PPP6R1 | 22870 | RNAseq | 0.0658 | 0.7524 | |
| SRP193095 | PPP6R1 | 22870 | RNAseq | 0.0829 | 0.6273 | |
| SRP219564 | PPP6R1 | 22870 | RNAseq | 0.0723 | 0.7406 |
Upregulated datasets: 0; Downregulated datasets: 0.
Copy number change of PPP6R1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP6R1 | 22870 | 3 | 4 | 23 | |
| GSE20123 | PPP6R1 | 22870 | 3 | 3 | 24 | |
| GSE43470 | PPP6R1 | 22870 | 3 | 11 | 29 | |
| GSE46452 | PPP6R1 | 22870 | 45 | 1 | 13 | |
| GSE47630 | PPP6R1 | 22870 | 8 | 6 | 26 | |
| GSE54993 | PPP6R1 | 22870 | 17 | 4 | 49 | |
| GSE54994 | PPP6R1 | 22870 | 4 | 13 | 36 | |
| GSE60625 | PPP6R1 | 22870 | 9 | 0 | 2 | |
| GSE74703 | PPP6R1 | 22870 | 3 | 7 | 26 | |
| GSE74704 | PPP6R1 | 22870 | 3 | 1 | 16 | |
| TCGA | PPP6R1 | 22870 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of PPP6R1:
Generating mutation plots.
Highly correlated genes for PPP6R1:
Showing top 20/850 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP6R1 | JMJD4 | 0.832075 | 3 | 0 | 3 |
| PPP6R1 | ZNF628 | 0.74002 | 3 | 0 | 3 |
| PPP6R1 | ZNF22 | 0.739972 | 3 | 0 | 3 |
| PPP6R1 | ZNF579 | 0.728322 | 5 | 0 | 5 |
| PPP6R1 | RPL7L1 | 0.725317 | 3 | 0 | 3 |
| PPP6R1 | CCDC167 | 0.724018 | 3 | 0 | 3 |
| PPP6R1 | XAB2 | 0.721119 | 4 | 0 | 4 |
| PPP6R1 | PIP4K2C | 0.720279 | 3 | 0 | 3 |
| PPP6R1 | LMF2 | 0.72015 | 3 | 0 | 3 |
| PPP6R1 | PRDM15 | 0.71655 | 3 | 0 | 3 |
| PPP6R1 | USP36 | 0.716421 | 3 | 0 | 3 |
| PPP6R1 | GPX7 | 0.715742 | 3 | 0 | 3 |
| PPP6R1 | GPAA1 | 0.714413 | 4 | 0 | 4 |
| PPP6R1 | SLC39A3 | 0.713808 | 5 | 0 | 4 |
| PPP6R1 | BRAT1 | 0.712813 | 3 | 0 | 3 |
| PPP6R1 | MAP3K2 | 0.70359 | 3 | 0 | 3 |
| PPP6R1 | GSK3A | 0.703488 | 3 | 0 | 3 |
| PPP6R1 | SHKBP1 | 0.703123 | 3 | 0 | 3 |
| PPP6R1 | NAA10 | 0.702723 | 5 | 0 | 5 |
| PPP6R1 | APOO | 0.702526 | 3 | 0 | 3 |
For details and further investigation, click here
