| Full name: glypican 3 | Alias Symbol: OCI-5|SGBS|SGBS1|SGB|DGSX | ||
| Type: protein-coding gene | Cytoband: Xq26.2 | ||
| Entrez ID: 2719 | HGNC ID: HGNC:4451 | Ensembl Gene: ENSG00000147257 | OMIM ID: 300037 |
| Drug and gene relationship at DGIdb | |||
GPC3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of GPC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPC3 | 2719 | 209220_at | 0.0124 | 0.9938 | |
| GSE20347 | GPC3 | 2719 | 209220_at | 0.9835 | 0.0027 | |
| GSE23400 | GPC3 | 2719 | 209220_at | 0.4780 | 0.0027 | |
| GSE26886 | GPC3 | 2719 | 209220_at | 1.0787 | 0.0251 | |
| GSE29001 | GPC3 | 2719 | 209220_at | 0.8411 | 0.0098 | |
| GSE38129 | GPC3 | 2719 | 209220_at | 0.7480 | 0.0610 | |
| GSE45670 | GPC3 | 2719 | 209220_at | 0.3023 | 0.6547 | |
| GSE53622 | GPC3 | 2719 | 42928 | 0.5492 | 0.0013 | |
| GSE53624 | GPC3 | 2719 | 42928 | 0.7492 | 0.0000 | |
| GSE63941 | GPC3 | 2719 | 209220_at | 1.2585 | 0.4457 | |
| GSE77861 | GPC3 | 2719 | 209220_at | 1.2004 | 0.1330 | |
| GSE97050 | GPC3 | 2719 | A_33_P3326634 | -0.0981 | 0.7867 | |
| SRP007169 | GPC3 | 2719 | RNAseq | 6.2909 | 0.0000 | |
| SRP064894 | GPC3 | 2719 | RNAseq | 0.9751 | 0.0379 | |
| SRP133303 | GPC3 | 2719 | RNAseq | 1.2165 | 0.0038 | |
| SRP219564 | GPC3 | 2719 | RNAseq | 1.0781 | 0.2358 | |
| TCGA | GPC3 | 2719 | RNAseq | -0.5067 | 0.1600 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by GPC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPC3:
No record found for this gene.
Somatic mutations of GPC3:
Generating mutation plots.
Highly correlated genes for GPC3:
Showing top 20/195 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPC3 | BCL2L13 | 0.761698 | 3 | 0 | 3 |
| GPC3 | SLC27A5 | 0.737552 | 4 | 0 | 4 |
| GPC3 | NID2 | 0.724736 | 3 | 0 | 3 |
| GPC3 | SV2B | 0.720625 | 4 | 0 | 3 |
| GPC3 | NRK | 0.707799 | 4 | 0 | 4 |
| GPC3 | FBLN2 | 0.700086 | 3 | 0 | 3 |
| GPC3 | ZBTB24 | 0.66138 | 3 | 0 | 3 |
| GPC3 | GPR161 | 0.661225 | 4 | 0 | 4 |
| GPC3 | STAC2 | 0.657948 | 3 | 0 | 3 |
| GPC3 | SOX2-OT | 0.654456 | 7 | 0 | 6 |
| GPC3 | ADAP1 | 0.64679 | 3 | 0 | 3 |
| GPC3 | TFE3 | 0.643664 | 5 | 0 | 3 |
| GPC3 | GNAZ | 0.636643 | 6 | 0 | 4 |
| GPC3 | KRTAP19-1 | 0.633036 | 5 | 0 | 4 |
| GPC3 | GTF2IRD2 | 0.632197 | 4 | 0 | 3 |
| GPC3 | ZNF428 | 0.6253 | 5 | 0 | 3 |
| GPC3 | MANBA | 0.622691 | 3 | 0 | 3 |
| GPC3 | CD81 | 0.6196 | 6 | 0 | 6 |
| GPC3 | CLDN3 | 0.619382 | 4 | 0 | 3 |
| GPC3 | UST | 0.618254 | 8 | 0 | 6 |
For details and further investigation, click here
