ZNF428

 

Full name: zinc finger protein 428 Alias Symbol: MGC51082|Zfp428
Type: protein-coding gene Cytoband: 19q13.31
Entrez ID: 126299 HGNC ID: HGNC:20804 Ensembl Gene: ENSG00000131116 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZNF428:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZNF428 126299 215429_s_at 0.0628 0.9254
GSE20347 ZNF428 126299 215429_s_at 0.1460 0.1424
GSE23400 ZNF428 126299 215429_s_at 0.1098 0.1081
GSE26886 ZNF428 126299 215429_s_at 0.6256 0.0000
GSE29001 ZNF428 126299 215429_s_at 0.2319 0.5040
GSE38129 ZNF428 126299 215429_s_at 0.1234 0.5816
GSE45670 ZNF428 126299 215429_s_at -0.1060 0.4700
GSE53622 ZNF428 126299 50236 -0.1364 0.0620
GSE53624 ZNF428 126299 50236 0.1013 0.0781
GSE63941 ZNF428 126299 215429_s_at -0.7053 0.0649
GSE77861 ZNF428 126299 215429_s_at 0.1820 0.2211
GSE97050 ZNF428 126299 A_33_P3339051 -0.3215 0.2858
SRP007169 ZNF428 126299 RNAseq 0.0725 0.8592
SRP008496 ZNF428 126299 RNAseq 0.2658 0.3927
SRP064894 ZNF428 126299 RNAseq 0.9032 0.0276
SRP133303 ZNF428 126299 RNAseq 0.0167 0.9078
SRP159526 ZNF428 126299 RNAseq 0.7509 0.0917
SRP193095 ZNF428 126299 RNAseq 0.2801 0.0241
SRP219564 ZNF428 126299 RNAseq -0.0205 0.9716
TCGA ZNF428 126299 RNAseq -0.0321 0.6799

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ZNF428 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZNF428:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF428 126299 6 5 19
GSE20123 ZNF428 126299 5 4 21
GSE43470 ZNF428 126299 4 11 28
GSE46452 ZNF428 126299 45 1 13
GSE47630 ZNF428 126299 8 6 26
GSE54993 ZNF428 126299 17 4 49
GSE54994 ZNF428 126299 6 12 35
GSE60625 ZNF428 126299 9 0 2
GSE74703 ZNF428 126299 4 7 25
GSE74704 ZNF428 126299 4 2 14
TCGA ZNF428 126299 14 16 66

Total number of gains: 122; Total number of losses: 68; Total Number of normals: 298.  

 

Somatic mutations of ZNF428:

 

Generating mutation plots.

 

Highly correlated genes for ZNF428:

 

Showing top 20/394 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF428STAC30.7813303
ZNF428TMEM1020.776811303
ZNF428SCUBE10.770502303
ZNF428GTF2IRD20.7695303
ZNF428SETD1B0.767178303
ZNF428SHISA40.727189504
ZNF428TREM10.722219303
ZNF428BAALC0.720693303
ZNF428ZNF5270.719936303
ZNF428RIMS30.719034303
ZNF428SPRED30.708786404
ZNF428SP80.703982303
ZNF428DUSP150.701829303
ZNF428SHISA60.697451303
ZNF428LENG10.69444404
ZNF428ISCU0.692331504
ZNF428TMUB10.687425505
ZNF428ANKRD520.685284504
ZNF428FBXL150.684078403
ZNF428CYP2A130.681152303

For details and further investigation, click here