| Full name: GPN-loop GTPase 3 | Alias Symbol: MGC14560 | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 51184 | HGNC ID: HGNC:30186 | Ensembl Gene: ENSG00000111231 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GPN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPN3 | 51184 | 218461_at | 0.3645 | 0.5016 | |
| GSE20347 | GPN3 | 51184 | 218461_at | 0.5861 | 0.0033 | |
| GSE23400 | GPN3 | 51184 | 218461_at | 0.3368 | 0.0000 | |
| GSE26886 | GPN3 | 51184 | 218461_at | 0.6608 | 0.0001 | |
| GSE29001 | GPN3 | 51184 | 218461_at | 0.5584 | 0.2011 | |
| GSE38129 | GPN3 | 51184 | 218461_at | 0.5234 | 0.0000 | |
| GSE45670 | GPN3 | 51184 | 218461_at | 0.3069 | 0.0103 | |
| GSE53622 | GPN3 | 51184 | 20642 | 0.3807 | 0.0000 | |
| GSE53624 | GPN3 | 51184 | 20642 | 0.6811 | 0.0000 | |
| GSE63941 | GPN3 | 51184 | 218461_at | 0.6513 | 0.0248 | |
| GSE77861 | GPN3 | 51184 | 218461_at | 0.4659 | 0.0269 | |
| GSE97050 | GPN3 | 51184 | A_33_P3389837 | 0.2290 | 0.4689 | |
| SRP007169 | GPN3 | 51184 | RNAseq | 0.7879 | 0.0233 | |
| SRP008496 | GPN3 | 51184 | RNAseq | 0.6834 | 0.0053 | |
| SRP064894 | GPN3 | 51184 | RNAseq | 0.3086 | 0.0699 | |
| SRP133303 | GPN3 | 51184 | RNAseq | 0.7547 | 0.0001 | |
| SRP159526 | GPN3 | 51184 | RNAseq | 0.4863 | 0.0599 | |
| SRP193095 | GPN3 | 51184 | RNAseq | 0.4178 | 0.0031 | |
| SRP219564 | GPN3 | 51184 | RNAseq | -0.1567 | 0.5361 | |
| TCGA | GPN3 | 51184 | RNAseq | 0.2377 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GPN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPN3 | 51184 | 5 | 3 | 22 | |
| GSE20123 | GPN3 | 51184 | 5 | 3 | 22 | |
| GSE43470 | GPN3 | 51184 | 2 | 1 | 40 | |
| GSE46452 | GPN3 | 51184 | 9 | 1 | 49 | |
| GSE47630 | GPN3 | 51184 | 9 | 3 | 28 | |
| GSE54993 | GPN3 | 51184 | 0 | 5 | 65 | |
| GSE54994 | GPN3 | 51184 | 4 | 3 | 46 | |
| GSE60625 | GPN3 | 51184 | 0 | 0 | 11 | |
| GSE74703 | GPN3 | 51184 | 2 | 0 | 34 | |
| GSE74704 | GPN3 | 51184 | 2 | 2 | 16 | |
| TCGA | GPN3 | 51184 | 22 | 10 | 64 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of GPN3:
Generating mutation plots.
Highly correlated genes for GPN3:
Showing top 20/1720 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPN3 | CMC1 | 0.778377 | 3 | 0 | 3 |
| GPN3 | SLC30A6 | 0.776499 | 3 | 0 | 3 |
| GPN3 | CYB5D1 | 0.7603 | 3 | 0 | 3 |
| GPN3 | PKIG | 0.747306 | 3 | 0 | 3 |
| GPN3 | ARPP19 | 0.739539 | 3 | 0 | 3 |
| GPN3 | PARP8 | 0.737872 | 3 | 0 | 3 |
| GPN3 | RICTOR | 0.736378 | 3 | 0 | 3 |
| GPN3 | MAPKAPK5 | 0.732618 | 13 | 0 | 12 |
| GPN3 | HRH1 | 0.725264 | 3 | 0 | 3 |
| GPN3 | C12orf66 | 0.725262 | 3 | 0 | 3 |
| GPN3 | SLC25A32 | 0.725205 | 11 | 0 | 10 |
| GPN3 | FASTKD1 | 0.719995 | 3 | 0 | 3 |
| GPN3 | SLC35B2 | 0.714711 | 3 | 0 | 3 |
| GPN3 | CMTM4 | 0.71279 | 4 | 0 | 3 |
| GPN3 | DMTF1 | 0.710228 | 4 | 0 | 4 |
| GPN3 | LRRC34 | 0.707445 | 3 | 0 | 3 |
| GPN3 | SETD6 | 0.702711 | 3 | 0 | 3 |
| GPN3 | EIF2D | 0.701669 | 3 | 0 | 3 |
| GPN3 | DDX60L | 0.700997 | 3 | 0 | 3 |
| GPN3 | FCGR3A | 0.699013 | 3 | 0 | 3 |
For details and further investigation, click here
