| Full name: histamine receptor H1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 3269 | HGNC ID: HGNC:5182 | Ensembl Gene: ENSG00000196639 | OMIM ID: 600167 |
| Drug and gene relationship at DGIdb | |||
HRH1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of HRH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HRH1 | 3269 | 205579_at | 0.7470 | 0.1731 | |
| GSE20347 | HRH1 | 3269 | 205580_s_at | 0.1701 | 0.2514 | |
| GSE23400 | HRH1 | 3269 | 205580_s_at | 0.0602 | 0.1936 | |
| GSE26886 | HRH1 | 3269 | 205579_at | 1.0344 | 0.0195 | |
| GSE29001 | HRH1 | 3269 | 205579_at | 0.4251 | 0.0756 | |
| GSE38129 | HRH1 | 3269 | 205580_s_at | 0.1688 | 0.2511 | |
| GSE45670 | HRH1 | 3269 | 205579_at | 0.8388 | 0.0316 | |
| GSE53622 | HRH1 | 3269 | 9359 | 0.0708 | 0.4489 | |
| GSE53624 | HRH1 | 3269 | 9359 | 0.1646 | 0.0292 | |
| GSE63941 | HRH1 | 3269 | 205579_at | -1.4931 | 0.1413 | |
| GSE77861 | HRH1 | 3269 | 205579_at | 0.1525 | 0.5735 | |
| GSE97050 | HRH1 | 3269 | A_33_P3245183 | 0.0441 | 0.8845 | |
| SRP007169 | HRH1 | 3269 | RNAseq | 2.5361 | 0.0004 | |
| SRP008496 | HRH1 | 3269 | RNAseq | 1.7920 | 0.0002 | |
| SRP064894 | HRH1 | 3269 | RNAseq | 0.6801 | 0.0306 | |
| SRP133303 | HRH1 | 3269 | RNAseq | 1.1104 | 0.0000 | |
| SRP159526 | HRH1 | 3269 | RNAseq | 0.3180 | 0.5864 | |
| SRP193095 | HRH1 | 3269 | RNAseq | 0.8596 | 0.0000 | |
| SRP219564 | HRH1 | 3269 | RNAseq | 0.2380 | 0.5757 | |
| TCGA | HRH1 | 3269 | RNAseq | 0.2956 | 0.0209 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by HRH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HRH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HRH1 | 3269 | 1 | 18 | 11 | |
| GSE20123 | HRH1 | 3269 | 1 | 19 | 10 | |
| GSE43470 | HRH1 | 3269 | 0 | 21 | 22 | |
| GSE46452 | HRH1 | 3269 | 2 | 17 | 40 | |
| GSE47630 | HRH1 | 3269 | 2 | 23 | 15 | |
| GSE54993 | HRH1 | 3269 | 6 | 1 | 63 | |
| GSE54994 | HRH1 | 3269 | 1 | 33 | 19 | |
| GSE60625 | HRH1 | 3269 | 5 | 0 | 6 | |
| GSE74703 | HRH1 | 3269 | 0 | 17 | 19 | |
| GSE74704 | HRH1 | 3269 | 1 | 10 | 9 | |
| TCGA | HRH1 | 3269 | 3 | 67 | 26 |
Total number of gains: 22; Total number of losses: 226; Total Number of normals: 240.
Somatic mutations of HRH1:
Generating mutation plots.
Highly correlated genes for HRH1:
Showing top 20/684 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HRH1 | IRF2BPL | 0.821769 | 3 | 0 | 3 |
| HRH1 | NOL10 | 0.782299 | 3 | 0 | 3 |
| HRH1 | IWS1 | 0.775902 | 3 | 0 | 3 |
| HRH1 | DDX20 | 0.77293 | 3 | 0 | 3 |
| HRH1 | RRM1 | 0.762022 | 3 | 0 | 3 |
| HRH1 | LSM5 | 0.751147 | 4 | 0 | 3 |
| HRH1 | ADAM19 | 0.748698 | 3 | 0 | 3 |
| HRH1 | BZW2 | 0.740161 | 3 | 0 | 3 |
| HRH1 | NUP205 | 0.726849 | 3 | 0 | 3 |
| HRH1 | NUTF2 | 0.726484 | 4 | 0 | 3 |
| HRH1 | GPN3 | 0.725264 | 3 | 0 | 3 |
| HRH1 | BCCIP | 0.724432 | 3 | 0 | 3 |
| HRH1 | TMEM208 | 0.721735 | 3 | 0 | 3 |
| HRH1 | NUDT15 | 0.720859 | 3 | 0 | 3 |
| HRH1 | KLHL21 | 0.713227 | 3 | 0 | 3 |
| HRH1 | TSN | 0.713159 | 4 | 0 | 3 |
| HRH1 | CDC42SE2 | 0.710579 | 3 | 0 | 3 |
| HRH1 | CDKN2D | 0.707496 | 3 | 0 | 3 |
| HRH1 | SLC25A24 | 0.707285 | 3 | 0 | 3 |
| HRH1 | LARS2 | 0.704855 | 4 | 0 | 3 |
For details and further investigation, click here
