| Full name: glycoprotein nmb | Alias Symbol: NMB|HGFIN | ||
| Type: protein-coding gene | Cytoband: 7p15.3 | ||
| Entrez ID: 10457 | HGNC ID: HGNC:4462 | Ensembl Gene: ENSG00000136235 | OMIM ID: 604368 |
| Drug and gene relationship at DGIdb | |||
Expression of GPNMB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPNMB | 10457 | 201141_at | 1.0941 | 0.0239 | |
| GSE20347 | GPNMB | 10457 | 201141_at | 1.8759 | 0.0000 | |
| GSE23400 | GPNMB | 10457 | 201141_at | 1.3868 | 0.0000 | |
| GSE26886 | GPNMB | 10457 | 201141_at | 1.3077 | 0.0027 | |
| GSE29001 | GPNMB | 10457 | 201141_at | 1.4604 | 0.0300 | |
| GSE38129 | GPNMB | 10457 | 201141_at | 1.6258 | 0.0000 | |
| GSE45670 | GPNMB | 10457 | 201141_at | 0.6803 | 0.1771 | |
| GSE53622 | GPNMB | 10457 | 62323 | 1.4142 | 0.0000 | |
| GSE53624 | GPNMB | 10457 | 62323 | 1.5725 | 0.0000 | |
| GSE63941 | GPNMB | 10457 | 201141_at | -3.3447 | 0.0954 | |
| GSE77861 | GPNMB | 10457 | 201141_at | 2.2379 | 0.0025 | |
| GSE97050 | GPNMB | 10457 | A_23_P134426 | 0.5966 | 0.2268 | |
| SRP007169 | GPNMB | 10457 | RNAseq | 2.9735 | 0.0000 | |
| SRP008496 | GPNMB | 10457 | RNAseq | 3.3836 | 0.0000 | |
| SRP064894 | GPNMB | 10457 | RNAseq | 1.7762 | 0.0000 | |
| SRP133303 | GPNMB | 10457 | RNAseq | 1.4412 | 0.0000 | |
| SRP159526 | GPNMB | 10457 | RNAseq | 1.6170 | 0.0146 | |
| SRP193095 | GPNMB | 10457 | RNAseq | 1.8419 | 0.0000 | |
| SRP219564 | GPNMB | 10457 | RNAseq | 1.1896 | 0.0969 | |
| TCGA | GPNMB | 10457 | RNAseq | 0.5100 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by GPNMB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPNMB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPNMB | 10457 | 17 | 1 | 12 | |
| GSE20123 | GPNMB | 10457 | 17 | 1 | 12 | |
| GSE43470 | GPNMB | 10457 | 4 | 0 | 39 | |
| GSE46452 | GPNMB | 10457 | 10 | 2 | 47 | |
| GSE47630 | GPNMB | 10457 | 9 | 1 | 30 | |
| GSE54993 | GPNMB | 10457 | 0 | 6 | 64 | |
| GSE54994 | GPNMB | 10457 | 20 | 2 | 31 | |
| GSE60625 | GPNMB | 10457 | 0 | 0 | 11 | |
| GSE74703 | GPNMB | 10457 | 4 | 0 | 32 | |
| GSE74704 | GPNMB | 10457 | 11 | 1 | 8 | |
| TCGA | GPNMB | 10457 | 56 | 4 | 36 |
Total number of gains: 148; Total number of losses: 18; Total Number of normals: 322.
Somatic mutations of GPNMB:
Generating mutation plots.
Highly correlated genes for GPNMB:
Showing top 20/1169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPNMB | FHL3 | 0.793494 | 3 | 0 | 3 |
| GPNMB | YWHAG | 0.726897 | 4 | 0 | 4 |
| GPNMB | MIB1 | 0.723282 | 3 | 0 | 3 |
| GPNMB | KRTCAP2 | 0.719316 | 3 | 0 | 3 |
| GPNMB | UHRF1 | 0.7171 | 4 | 0 | 4 |
| GPNMB | RILPL1 | 0.7164 | 3 | 0 | 3 |
| GPNMB | TMEM138 | 0.71083 | 7 | 0 | 7 |
| GPNMB | EMILIN2 | 0.704401 | 5 | 0 | 5 |
| GPNMB | NCOR2 | 0.69973 | 6 | 0 | 6 |
| GPNMB | SORL1 | 0.693872 | 3 | 0 | 3 |
| GPNMB | LAPTM4B | 0.693465 | 11 | 0 | 11 |
| GPNMB | TMEM184B | 0.68888 | 10 | 0 | 10 |
| GPNMB | PELI2 | 0.688868 | 4 | 0 | 3 |
| GPNMB | SPON2 | 0.686816 | 3 | 0 | 3 |
| GPNMB | ZCCHC3 | 0.684254 | 5 | 0 | 5 |
| GPNMB | KIAA0930 | 0.680584 | 11 | 0 | 10 |
| GPNMB | CD276 | 0.679771 | 4 | 0 | 3 |
| GPNMB | WDR66 | 0.676995 | 6 | 0 | 6 |
| GPNMB | FZD6 | 0.675455 | 10 | 0 | 9 |
| GPNMB | PCDH19 | 0.674048 | 3 | 0 | 3 |
For details and further investigation, click here
