| Full name: mindbomb E3 ubiquitin protein ligase 1 | Alias Symbol: DIP-1|MIB|KIAA1323|ZZANK2|ZZZ6 | ||
| Type: protein-coding gene | Cytoband: 18q11.2 | ||
| Entrez ID: 57534 | HGNC ID: HGNC:21086 | Ensembl Gene: ENSG00000101752 | OMIM ID: 608677 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MIB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MIB1 | 57534 | 224720_at | 0.2277 | 0.3794 | |
| GSE26886 | MIB1 | 57534 | 224720_at | 0.3192 | 0.1517 | |
| GSE45670 | MIB1 | 57534 | 224726_at | 0.0558 | 0.7363 | |
| GSE53622 | MIB1 | 57534 | 119283 | 0.1494 | 0.2606 | |
| GSE53624 | MIB1 | 57534 | 119283 | 0.3469 | 0.0005 | |
| GSE63941 | MIB1 | 57534 | 224720_at | -0.3174 | 0.4745 | |
| GSE77861 | MIB1 | 57534 | 224720_at | 0.6325 | 0.2447 | |
| GSE97050 | MIB1 | 57534 | A_33_P3347976 | 0.0170 | 0.9635 | |
| SRP007169 | MIB1 | 57534 | RNAseq | 0.8276 | 0.0049 | |
| SRP008496 | MIB1 | 57534 | RNAseq | 0.8387 | 0.0000 | |
| SRP064894 | MIB1 | 57534 | RNAseq | -0.0766 | 0.7790 | |
| SRP133303 | MIB1 | 57534 | RNAseq | 0.4506 | 0.0044 | |
| SRP159526 | MIB1 | 57534 | RNAseq | 0.4186 | 0.0023 | |
| SRP193095 | MIB1 | 57534 | RNAseq | 0.2522 | 0.0155 | |
| SRP219564 | MIB1 | 57534 | RNAseq | -0.1566 | 0.5139 | |
| TCGA | MIB1 | 57534 | RNAseq | -0.0169 | 0.7339 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MIB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MIB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MIB1 | 57534 | 2 | 6 | 22 | |
| GSE20123 | MIB1 | 57534 | 1 | 6 | 23 | |
| GSE43470 | MIB1 | 57534 | 2 | 3 | 38 | |
| GSE46452 | MIB1 | 57534 | 3 | 22 | 34 | |
| GSE47630 | MIB1 | 57534 | 7 | 17 | 16 | |
| GSE54993 | MIB1 | 57534 | 7 | 1 | 62 | |
| GSE54994 | MIB1 | 57534 | 3 | 12 | 38 | |
| GSE60625 | MIB1 | 57534 | 0 | 4 | 7 | |
| GSE74703 | MIB1 | 57534 | 2 | 2 | 32 | |
| GSE74704 | MIB1 | 57534 | 1 | 5 | 14 | |
| TCGA | MIB1 | 57534 | 18 | 18 | 60 |
Total number of gains: 46; Total number of losses: 96; Total Number of normals: 346.
Somatic mutations of MIB1:
Generating mutation plots.
Highly correlated genes for MIB1:
Showing top 20/458 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MIB1 | RNF13 | 0.77921 | 4 | 0 | 4 |
| MIB1 | RAB31 | 0.772876 | 3 | 0 | 3 |
| MIB1 | TOR1B | 0.761185 | 3 | 0 | 3 |
| MIB1 | PDE8A | 0.740875 | 3 | 0 | 3 |
| MIB1 | RRM2B | 0.732151 | 3 | 0 | 3 |
| MIB1 | GPNMB | 0.723282 | 3 | 0 | 3 |
| MIB1 | FAM168B | 0.716592 | 3 | 0 | 3 |
| MIB1 | EBAG9 | 0.709063 | 4 | 0 | 4 |
| MIB1 | PET117 | 0.698225 | 3 | 0 | 3 |
| MIB1 | COCH | 0.696626 | 4 | 0 | 4 |
| MIB1 | DOCK5 | 0.695802 | 3 | 0 | 3 |
| MIB1 | LATS1 | 0.695692 | 3 | 0 | 3 |
| MIB1 | SEC22A | 0.690309 | 3 | 0 | 3 |
| MIB1 | TRAF3 | 0.683132 | 3 | 0 | 3 |
| MIB1 | MTO1 | 0.680035 | 3 | 0 | 3 |
| MIB1 | UBR5 | 0.678146 | 3 | 0 | 3 |
| MIB1 | TIMM9 | 0.674635 | 3 | 0 | 3 |
| MIB1 | FUS | 0.66924 | 4 | 0 | 3 |
| MIB1 | RRAS2 | 0.669028 | 4 | 0 | 3 |
| MIB1 | TAOK1 | 0.668764 | 3 | 0 | 3 |
For details and further investigation, click here
