| Full name: ubiquitin like with PHD and ring finger domains 1 | Alias Symbol: ICBP90|Np95|FLJ21925|RNF106|TDRD22 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 29128 | HGNC ID: HGNC:12556 | Ensembl Gene: ENSG00000276043 | OMIM ID: 607990 |
| Drug and gene relationship at DGIdb | |||
Expression of UHRF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UHRF1 | 29128 | 225655_at | 1.6610 | 0.0330 | |
| GSE26886 | UHRF1 | 29128 | 225655_at | 1.1090 | 0.0055 | |
| GSE45670 | UHRF1 | 29128 | 225655_at | 1.9101 | 0.0000 | |
| GSE53622 | UHRF1 | 29128 | 54257 | 2.0987 | 0.0000 | |
| GSE53624 | UHRF1 | 29128 | 85946 | 1.9703 | 0.0000 | |
| GSE63941 | UHRF1 | 29128 | 225655_at | 1.9063 | 0.0083 | |
| GSE77861 | UHRF1 | 29128 | 225655_at | 1.9385 | 0.0003 | |
| GSE97050 | UHRF1 | 29128 | A_23_P208880 | 0.9694 | 0.1581 | |
| SRP007169 | UHRF1 | 29128 | RNAseq | 2.3818 | 0.0003 | |
| SRP008496 | UHRF1 | 29128 | RNAseq | 1.8461 | 0.0004 | |
| SRP064894 | UHRF1 | 29128 | RNAseq | 1.7007 | 0.0000 | |
| SRP133303 | UHRF1 | 29128 | RNAseq | 1.6400 | 0.0000 | |
| SRP159526 | UHRF1 | 29128 | RNAseq | 1.6986 | 0.0001 | |
| SRP193095 | UHRF1 | 29128 | RNAseq | 1.3615 | 0.0000 | |
| SRP219564 | UHRF1 | 29128 | RNAseq | 2.0409 | 0.0069 | |
| TCGA | UHRF1 | 29128 | RNAseq | 1.2258 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by UHRF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UHRF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UHRF1 | 29128 | 5 | 3 | 22 | |
| GSE20123 | UHRF1 | 29128 | 4 | 2 | 24 | |
| GSE43470 | UHRF1 | 29128 | 1 | 8 | 34 | |
| GSE46452 | UHRF1 | 29128 | 47 | 1 | 11 | |
| GSE47630 | UHRF1 | 29128 | 5 | 7 | 28 | |
| GSE54993 | UHRF1 | 29128 | 16 | 3 | 51 | |
| GSE54994 | UHRF1 | 29128 | 6 | 16 | 31 | |
| GSE60625 | UHRF1 | 29128 | 9 | 0 | 2 | |
| GSE74703 | UHRF1 | 29128 | 1 | 5 | 30 | |
| GSE74704 | UHRF1 | 29128 | 1 | 2 | 17 | |
| TCGA | UHRF1 | 29128 | 11 | 18 | 67 |
Total number of gains: 106; Total number of losses: 65; Total Number of normals: 317.
Somatic mutations of UHRF1:
Generating mutation plots.
Highly correlated genes for UHRF1:
Showing top 20/1671 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UHRF1 | KIF18B | 0.866921 | 7 | 0 | 7 |
| UHRF1 | NCAPH | 0.861015 | 5 | 0 | 5 |
| UHRF1 | CDC45 | 0.849751 | 8 | 0 | 8 |
| UHRF1 | BIRC5 | 0.842648 | 8 | 0 | 8 |
| UHRF1 | KIF4A | 0.836479 | 8 | 0 | 8 |
| UHRF1 | MYBL2 | 0.829813 | 8 | 0 | 8 |
| UHRF1 | MTFR2 | 0.827725 | 7 | 0 | 7 |
| UHRF1 | CDC6 | 0.826255 | 5 | 0 | 5 |
| UHRF1 | AURKB | 0.816302 | 9 | 0 | 9 |
| UHRF1 | RAD51AP1 | 0.814287 | 9 | 0 | 9 |
| UHRF1 | IGF2BP2 | 0.813543 | 7 | 0 | 7 |
| UHRF1 | TRIP13 | 0.811497 | 9 | 0 | 8 |
| UHRF1 | CDK1 | 0.811446 | 8 | 0 | 8 |
| UHRF1 | PNPT1 | 0.810988 | 6 | 0 | 6 |
| UHRF1 | MCM2 | 0.808355 | 9 | 0 | 9 |
| UHRF1 | TPX2 | 0.808283 | 9 | 0 | 9 |
| UHRF1 | CMSS1 | 0.806947 | 6 | 0 | 6 |
| UHRF1 | TOP2A | 0.805035 | 9 | 0 | 9 |
| UHRF1 | DTL | 0.80476 | 9 | 0 | 8 |
| UHRF1 | KIF2C | 0.799057 | 9 | 0 | 8 |
For details and further investigation, click here
