| Full name: G protein-coupled receptor 12 | Alias Symbol: GPCR21|PPP1R84 | ||
| Type: protein-coding gene | Cytoband: 13q12.13 | ||
| Entrez ID: 2835 | HGNC ID: HGNC:4466 | Ensembl Gene: ENSG00000132975 | OMIM ID: 600752 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR12 | 2835 | 1559603_at | -0.1878 | 0.6387 | |
| GSE20347 | GPR12 | 2835 | 214558_at | -0.1513 | 0.1128 | |
| GSE23400 | GPR12 | 2835 | 214558_at | -0.1747 | 0.0023 | |
| GSE26886 | GPR12 | 2835 | 214558_at | -0.0384 | 0.8035 | |
| GSE29001 | GPR12 | 2835 | 214558_at | -0.1965 | 0.2394 | |
| GSE38129 | GPR12 | 2835 | 214558_at | -0.2351 | 0.1107 | |
| GSE45670 | GPR12 | 2835 | 1559603_at | -0.0178 | 0.8915 | |
| GSE53622 | GPR12 | 2835 | 83454 | -1.2296 | 0.0000 | |
| GSE53624 | GPR12 | 2835 | 83454 | -1.8235 | 0.0000 | |
| GSE63941 | GPR12 | 2835 | 1559603_at | -0.0123 | 0.9467 | |
| GSE77861 | GPR12 | 2835 | 214558_at | -0.0595 | 0.7052 | |
| SRP133303 | GPR12 | 2835 | RNAseq | -1.0861 | 0.0103 | |
| TCGA | GPR12 | 2835 | RNAseq | -2.2490 | 0.0229 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by GPR12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR12 | 2835 | 1 | 13 | 16 | |
| GSE20123 | GPR12 | 2835 | 1 | 12 | 17 | |
| GSE43470 | GPR12 | 2835 | 2 | 12 | 29 | |
| GSE46452 | GPR12 | 2835 | 0 | 33 | 26 | |
| GSE47630 | GPR12 | 2835 | 3 | 26 | 11 | |
| GSE54993 | GPR12 | 2835 | 11 | 2 | 57 | |
| GSE54994 | GPR12 | 2835 | 1 | 13 | 39 | |
| GSE60625 | GPR12 | 2835 | 0 | 3 | 8 | |
| GSE74703 | GPR12 | 2835 | 2 | 9 | 25 | |
| GSE74704 | GPR12 | 2835 | 0 | 10 | 10 | |
| TCGA | GPR12 | 2835 | 6 | 43 | 47 |
Total number of gains: 27; Total number of losses: 176; Total Number of normals: 285.
Somatic mutations of GPR12:
Generating mutation plots.
Highly correlated genes for GPR12:
Showing top 20/658 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR12 | HEYL | 0.729886 | 4 | 0 | 4 |
| GPR12 | CER1 | 0.715846 | 4 | 0 | 3 |
| GPR12 | EDA2R | 0.714761 | 4 | 0 | 4 |
| GPR12 | SLC22A13 | 0.709159 | 4 | 0 | 4 |
| GPR12 | INO80D | 0.709037 | 4 | 0 | 4 |
| GPR12 | MYT1 | 0.696345 | 4 | 0 | 4 |
| GPR12 | OR10H3 | 0.694555 | 6 | 0 | 6 |
| GPR12 | TCP10L | 0.691648 | 4 | 0 | 4 |
| GPR12 | CRHR2 | 0.691108 | 5 | 0 | 4 |
| GPR12 | ENTPD2 | 0.690311 | 3 | 0 | 3 |
| GPR12 | TEX15 | 0.689223 | 4 | 0 | 4 |
| GPR12 | GJD2 | 0.687966 | 5 | 0 | 5 |
| GPR12 | FGF16 | 0.683508 | 5 | 0 | 5 |
| GPR12 | KIR2DS4 | 0.679701 | 4 | 0 | 4 |
| GPR12 | DRD5 | 0.677321 | 6 | 0 | 5 |
| GPR12 | IFNA21 | 0.675848 | 6 | 0 | 5 |
| GPR12 | CCL1 | 0.675312 | 4 | 0 | 4 |
| GPR12 | EPB42 | 0.670985 | 5 | 0 | 5 |
| GPR12 | CEACAM3 | 0.66674 | 6 | 0 | 6 |
| GPR12 | GPR22 | 0.665783 | 4 | 0 | 4 |
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