| Full name: G protein-coupled receptor 22 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q22.3 | ||
| Entrez ID: 2845 | HGNC ID: HGNC:4477 | Ensembl Gene: ENSG00000172209 | OMIM ID: 601910 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR22 | 2845 | 221288_at | -0.0325 | 0.9143 | |
| GSE20347 | GPR22 | 2845 | 221288_at | 0.1160 | 0.0789 | |
| GSE23400 | GPR22 | 2845 | 221288_at | -0.0136 | 0.7733 | |
| GSE26886 | GPR22 | 2845 | 221288_at | 0.0697 | 0.3412 | |
| GSE29001 | GPR22 | 2845 | 221288_at | -0.2282 | 0.2153 | |
| GSE38129 | GPR22 | 2845 | 221288_at | 0.0323 | 0.6606 | |
| GSE45670 | GPR22 | 2845 | 221288_at | 0.0979 | 0.3783 | |
| GSE63941 | GPR22 | 2845 | 221288_at | 0.3481 | 0.1642 | |
| GSE77861 | GPR22 | 2845 | 221288_at | 0.0190 | 0.8362 | |
| SRP133303 | GPR22 | 2845 | RNAseq | 0.5361 | 0.0118 | |
| SRP193095 | GPR22 | 2845 | RNAseq | 0.1773 | 0.2797 | |
| TCGA | GPR22 | 2845 | RNAseq | -0.3608 | 0.4885 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GPR22 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GPR22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR22 | 2845 | 12 | 0 | 18 | |
| GSE20123 | GPR22 | 2845 | 12 | 0 | 18 | |
| GSE43470 | GPR22 | 2845 | 6 | 2 | 35 | |
| GSE46452 | GPR22 | 2845 | 10 | 1 | 48 | |
| GSE47630 | GPR22 | 2845 | 8 | 3 | 29 | |
| GSE54993 | GPR22 | 2845 | 2 | 9 | 59 | |
| GSE54994 | GPR22 | 2845 | 16 | 3 | 34 | |
| GSE60625 | GPR22 | 2845 | 0 | 0 | 11 | |
| GSE74703 | GPR22 | 2845 | 6 | 2 | 28 | |
| GSE74704 | GPR22 | 2845 | 8 | 0 | 12 | |
| TCGA | GPR22 | 2845 | 49 | 11 | 36 |
Total number of gains: 129; Total number of losses: 31; Total Number of normals: 328.
Somatic mutations of GPR22:
Generating mutation plots.
Highly correlated genes for GPR22:
Showing top 20/541 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR22 | CA8 | 0.756573 | 3 | 0 | 3 |
| GPR22 | FAM223B | 0.716216 | 3 | 0 | 3 |
| GPR22 | FGF20 | 0.704994 | 3 | 0 | 3 |
| GPR22 | ZYX | 0.686585 | 3 | 0 | 3 |
| GPR22 | TBR1 | 0.684373 | 4 | 0 | 3 |
| GPR22 | SLC17A1 | 0.681464 | 5 | 0 | 5 |
| GPR22 | MC2R | 0.677791 | 5 | 0 | 4 |
| GPR22 | FOXN3-AS2 | 0.675031 | 4 | 0 | 3 |
| GPR22 | GDF9 | 0.672665 | 4 | 0 | 4 |
| GPR22 | OR10H3 | 0.672106 | 5 | 0 | 5 |
| GPR22 | CXCR1 | 0.671783 | 3 | 0 | 3 |
| GPR22 | CDH10 | 0.671592 | 3 | 0 | 3 |
| GPR22 | CNTD2 | 0.671365 | 4 | 0 | 4 |
| GPR22 | GPR12 | 0.665783 | 4 | 0 | 4 |
| GPR22 | CGA | 0.665758 | 4 | 0 | 4 |
| GPR22 | CNGB3 | 0.665256 | 5 | 0 | 5 |
| GPR22 | CRHR2 | 0.663597 | 4 | 0 | 3 |
| GPR22 | C6 | 0.659159 | 4 | 0 | 3 |
| GPR22 | USH1C | 0.658238 | 6 | 0 | 5 |
| GPR22 | AQP6 | 0.657772 | 5 | 0 | 4 |
For details and further investigation, click here
