| Full name: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 | Alias Symbol: cl-39|KKA3|nkat8|CD158I | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 3809 | HGNC ID: HGNC:6336 | Ensembl Gene: ENSG00000221957 | OMIM ID: 604955 |
| Drug and gene relationship at DGIdb | |||
KIR2DS4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of KIR2DS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIR2DS4 | 3809 | 216552_x_at | -0.1308 | 0.6571 | |
| GSE20347 | KIR2DS4 | 3809 | 216552_x_at | -0.0240 | 0.7771 | |
| GSE23400 | KIR2DS4 | 3809 | 216552_x_at | -0.1619 | 0.0000 | |
| GSE26886 | KIR2DS4 | 3809 | 216552_x_at | 0.2015 | 0.0237 | |
| GSE29001 | KIR2DS4 | 3809 | 216552_x_at | -0.1607 | 0.1674 | |
| GSE38129 | KIR2DS4 | 3809 | 216552_x_at | -0.0976 | 0.1479 | |
| GSE45670 | KIR2DS4 | 3809 | 216552_x_at | -0.0037 | 0.9802 | |
| GSE63941 | KIR2DS4 | 3809 | 216552_x_at | -0.0382 | 0.8402 | |
| GSE77861 | KIR2DS4 | 3809 | 216552_x_at | -0.1344 | 0.2336 | |
| GSE97050 | KIR2DS4 | 3809 | A_24_P87746 | 0.5899 | 0.4322 | |
| TCGA | KIR2DS4 | 3809 | RNAseq | 2.0816 | 0.0897 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KIR2DS4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KIR2DS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIR2DS4 | 3809 | 3 | 4 | 23 | |
| GSE20123 | KIR2DS4 | 3809 | 3 | 3 | 24 | |
| GSE43470 | KIR2DS4 | 3809 | 3 | 11 | 29 | |
| GSE46452 | KIR2DS4 | 3809 | 45 | 1 | 13 | |
| GSE47630 | KIR2DS4 | 3809 | 8 | 6 | 26 | |
| GSE54993 | KIR2DS4 | 3809 | 17 | 4 | 49 | |
| GSE54994 | KIR2DS4 | 3809 | 4 | 13 | 36 | |
| GSE60625 | KIR2DS4 | 3809 | 9 | 0 | 2 | |
| GSE74703 | KIR2DS4 | 3809 | 3 | 7 | 26 | |
| GSE74704 | KIR2DS4 | 3809 | 3 | 1 | 16 | |
| TCGA | KIR2DS4 | 3809 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of KIR2DS4:
Generating mutation plots.
Highly correlated genes for KIR2DS4:
Showing top 20/678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIR2DS4 | ADCYAP1 | 0.695474 | 3 | 0 | 3 |
| KIR2DS4 | PRL | 0.694671 | 6 | 0 | 6 |
| KIR2DS4 | G6PC2 | 0.683334 | 5 | 0 | 5 |
| KIR2DS4 | CYP4A11 | 0.680895 | 5 | 0 | 5 |
| KIR2DS4 | GPR12 | 0.679701 | 4 | 0 | 4 |
| KIR2DS4 | NOS1 | 0.674951 | 4 | 0 | 4 |
| KIR2DS4 | DRD5 | 0.674101 | 6 | 0 | 6 |
| KIR2DS4 | BCAN | 0.673743 | 4 | 0 | 4 |
| KIR2DS4 | SLC5A5 | 0.672578 | 5 | 0 | 5 |
| KIR2DS4 | CETN1 | 0.670146 | 4 | 0 | 3 |
| KIR2DS4 | RABEP2 | 0.666073 | 3 | 0 | 3 |
| KIR2DS4 | PPFIA2 | 0.665172 | 4 | 0 | 4 |
| KIR2DS4 | CHAD | 0.66162 | 4 | 0 | 4 |
| KIR2DS4 | CAV3 | 0.65995 | 5 | 0 | 4 |
| KIR2DS4 | TMPRSS15 | 0.65756 | 4 | 0 | 4 |
| KIR2DS4 | RHAG | 0.656892 | 3 | 0 | 3 |
| KIR2DS4 | IFNA2 | 0.650835 | 3 | 0 | 3 |
| KIR2DS4 | SPP2 | 0.650674 | 3 | 0 | 3 |
| KIR2DS4 | CAMK1G | 0.650431 | 4 | 0 | 3 |
| KIR2DS4 | SLC10A1 | 0.647956 | 5 | 0 | 4 |
For details and further investigation, click here
