| Full name: zyxin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 7791 | HGNC ID: HGNC:13200 | Ensembl Gene: ENSG00000159840 | OMIM ID: 602002 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ZYX involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion |
Expression of ZYX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZYX | 7791 | 215706_x_at | 0.0771 | 0.9168 | |
| GSE20347 | ZYX | 7791 | 215706_x_at | 0.2968 | 0.0377 | |
| GSE23400 | ZYX | 7791 | 215706_x_at | 0.0379 | 0.6545 | |
| GSE26886 | ZYX | 7791 | 215706_x_at | 0.1759 | 0.5814 | |
| GSE29001 | ZYX | 7791 | 215706_x_at | -0.0738 | 0.8003 | |
| GSE38129 | ZYX | 7791 | 215706_x_at | 0.1074 | 0.5454 | |
| GSE45670 | ZYX | 7791 | 215706_x_at | -0.0834 | 0.5453 | |
| GSE53622 | ZYX | 7791 | 53759 | 0.1398 | 0.1239 | |
| GSE53624 | ZYX | 7791 | 53759 | 0.4313 | 0.0000 | |
| GSE63941 | ZYX | 7791 | 215706_x_at | 0.3440 | 0.4208 | |
| GSE77861 | ZYX | 7791 | 215706_x_at | 0.4961 | 0.1187 | |
| GSE97050 | ZYX | 7791 | A_23_P254888 | 0.3945 | 0.2493 | |
| SRP007169 | ZYX | 7791 | RNAseq | 2.6399 | 0.0000 | |
| SRP008496 | ZYX | 7791 | RNAseq | 2.4495 | 0.0000 | |
| SRP064894 | ZYX | 7791 | RNAseq | 0.4990 | 0.0749 | |
| SRP133303 | ZYX | 7791 | RNAseq | 0.4577 | 0.0500 | |
| SRP159526 | ZYX | 7791 | RNAseq | -0.2650 | 0.4448 | |
| SRP193095 | ZYX | 7791 | RNAseq | 0.9673 | 0.0000 | |
| SRP219564 | ZYX | 7791 | RNAseq | -0.5360 | 0.3763 | |
| TCGA | ZYX | 7791 | RNAseq | 0.0233 | 0.6761 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ZYX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZYX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZYX | 7791 | 4 | 2 | 24 | |
| GSE20123 | ZYX | 7791 | 4 | 2 | 24 | |
| GSE43470 | ZYX | 7791 | 3 | 4 | 36 | |
| GSE46452 | ZYX | 7791 | 7 | 2 | 50 | |
| GSE47630 | ZYX | 7791 | 6 | 7 | 27 | |
| GSE54993 | ZYX | 7791 | 3 | 4 | 63 | |
| GSE54994 | ZYX | 7791 | 5 | 8 | 40 | |
| GSE60625 | ZYX | 7791 | 0 | 0 | 11 | |
| GSE74703 | ZYX | 7791 | 2 | 4 | 30 | |
| GSE74704 | ZYX | 7791 | 2 | 2 | 16 | |
| TCGA | ZYX | 7791 | 28 | 25 | 43 |
Total number of gains: 64; Total number of losses: 60; Total Number of normals: 364.
Somatic mutations of ZYX:
Generating mutation plots.
Highly correlated genes for ZYX:
Showing top 20/715 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZYX | DAPK3 | 0.767285 | 3 | 0 | 3 |
| ZYX | INO80E | 0.74076 | 3 | 0 | 3 |
| ZYX | CD80 | 0.732946 | 3 | 0 | 3 |
| ZYX | STAC | 0.731307 | 3 | 0 | 3 |
| ZYX | CCDC155 | 0.721217 | 3 | 0 | 3 |
| ZYX | SCAMP4 | 0.720353 | 3 | 0 | 3 |
| ZYX | DARS2 | 0.71903 | 3 | 0 | 3 |
| ZYX | ZNF747 | 0.714238 | 5 | 0 | 5 |
| ZYX | FAM20C | 0.712981 | 3 | 0 | 3 |
| ZYX | CCM2 | 0.710198 | 3 | 0 | 3 |
| ZYX | SLC12A5 | 0.708675 | 4 | 0 | 4 |
| ZYX | SH2D3C | 0.708435 | 3 | 0 | 3 |
| ZYX | TP53I13 | 0.704405 | 3 | 0 | 3 |
| ZYX | SHANK3 | 0.702398 | 3 | 0 | 3 |
| ZYX | PDLIM7 | 0.702142 | 9 | 0 | 7 |
| ZYX | RABEP2 | 0.702142 | 3 | 0 | 3 |
| ZYX | CTF1 | 0.699309 | 5 | 0 | 5 |
| ZYX | IMPDH1 | 0.697989 | 5 | 0 | 4 |
| ZYX | MOGS | 0.694448 | 3 | 0 | 3 |
| ZYX | C11orf1 | 0.693766 | 3 | 0 | 3 |
For details and further investigation, click here
