| Full name: G protein-coupled receptor 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 2830 | HGNC ID: HGNC:4515 | Ensembl Gene: ENSG00000146360 | OMIM ID: 600553 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GPR6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR6 | 2830 | 1553507_a_at | -0.1735 | 0.6478 | |
| GSE20347 | GPR6 | 2830 | 214655_at | 0.0925 | 0.1462 | |
| GSE23400 | GPR6 | 2830 | 214655_at | -0.0094 | 0.7672 | |
| GSE26886 | GPR6 | 2830 | 1553507_a_at | -0.0974 | 0.4581 | |
| GSE29001 | GPR6 | 2830 | 214655_at | 0.0699 | 0.5996 | |
| GSE38129 | GPR6 | 2830 | 214655_at | 0.0205 | 0.7341 | |
| GSE45670 | GPR6 | 2830 | 1553507_a_at | 0.0421 | 0.6886 | |
| GSE53622 | GPR6 | 2830 | 45089 | -0.1666 | 0.4114 | |
| GSE53624 | GPR6 | 2830 | 45089 | -0.0676 | 0.7685 | |
| GSE63941 | GPR6 | 2830 | 1553507_a_at | 0.1887 | 0.2560 | |
| GSE77861 | GPR6 | 2830 | 1553507_a_at | -0.0238 | 0.8388 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GPR6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR6 | 2830 | 2 | 3 | 25 | |
| GSE20123 | GPR6 | 2830 | 2 | 2 | 26 | |
| GSE43470 | GPR6 | 2830 | 3 | 1 | 39 | |
| GSE46452 | GPR6 | 2830 | 2 | 11 | 46 | |
| GSE47630 | GPR6 | 2830 | 9 | 4 | 27 | |
| GSE54993 | GPR6 | 2830 | 3 | 2 | 65 | |
| GSE54994 | GPR6 | 2830 | 8 | 8 | 37 | |
| GSE60625 | GPR6 | 2830 | 0 | 2 | 9 | |
| GSE74703 | GPR6 | 2830 | 2 | 1 | 33 | |
| GSE74704 | GPR6 | 2830 | 0 | 0 | 20 | |
| TCGA | GPR6 | 2830 | 6 | 23 | 67 |
Total number of gains: 37; Total number of losses: 57; Total Number of normals: 394.
Somatic mutations of GPR6:
Generating mutation plots.
Highly correlated genes for GPR6:
Showing top 20/206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR6 | NYAP2 | 0.696933 | 3 | 0 | 3 |
| GPR6 | GSX1 | 0.645556 | 4 | 0 | 3 |
| GPR6 | UCN3 | 0.641012 | 5 | 0 | 5 |
| GPR6 | STX1B | 0.64097 | 3 | 0 | 3 |
| GPR6 | LINC00710 | 0.638139 | 4 | 0 | 3 |
| GPR6 | C1orf194 | 0.632115 | 3 | 0 | 3 |
| GPR6 | ANHX | 0.625954 | 4 | 0 | 3 |
| GPR6 | SLC5A2 | 0.62536 | 5 | 0 | 4 |
| GPR6 | HRH2 | 0.620524 | 4 | 0 | 3 |
| GPR6 | CCDC154 | 0.615828 | 4 | 0 | 3 |
| GPR6 | LINC01122 | 0.613886 | 3 | 0 | 3 |
| GPR6 | KLHL25 | 0.607546 | 3 | 0 | 3 |
| GPR6 | LYZL1 | 0.603639 | 4 | 0 | 3 |
| GPR6 | TSSK3 | 0.602841 | 4 | 0 | 3 |
| GPR6 | CACNA1I | 0.60036 | 4 | 0 | 4 |
| GPR6 | SPRR4 | 0.598809 | 3 | 0 | 3 |
| GPR6 | SLC22A6 | 0.596214 | 4 | 0 | 3 |
| GPR6 | DEFB108B | 0.596176 | 4 | 0 | 3 |
| GPR6 | MAG | 0.594112 | 4 | 0 | 4 |
| GPR6 | PSG9 | 0.589532 | 4 | 0 | 3 |
For details and further investigation, click here
