| Full name: solute carrier family 22 member 6 | Alias Symbol: ROAT1|PAHT|OAT1 | ||
| Type: protein-coding gene | Cytoband: 11q12.3 | ||
| Entrez ID: 9356 | HGNC ID: HGNC:10970 | Ensembl Gene: ENSG00000197901 | OMIM ID: 607582 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC22A6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC22A6 | 9356 | 210343_s_at | 0.0303 | 0.9323 | |
| GSE20347 | SLC22A6 | 9356 | 210343_s_at | -0.0897 | 0.1600 | |
| GSE23400 | SLC22A6 | 9356 | 210343_s_at | -0.0708 | 0.0208 | |
| GSE26886 | SLC22A6 | 9356 | 210343_s_at | 0.4251 | 0.0087 | |
| GSE29001 | SLC22A6 | 9356 | 216599_x_at | 0.0996 | 0.4001 | |
| GSE38129 | SLC22A6 | 9356 | 210343_s_at | -0.1183 | 0.1228 | |
| GSE45670 | SLC22A6 | 9356 | 210343_s_at | -0.0424 | 0.7096 | |
| GSE53622 | SLC22A6 | 9356 | 85782 | 0.4764 | 0.0002 | |
| GSE53624 | SLC22A6 | 9356 | 85782 | 0.1160 | 0.4252 | |
| GSE63941 | SLC22A6 | 9356 | 210343_s_at | 0.1100 | 0.6036 | |
| GSE77861 | SLC22A6 | 9356 | 210343_s_at | -0.1175 | 0.4720 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SLC22A6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC22A6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC22A6 | 9356 | 6 | 5 | 19 | |
| GSE20123 | SLC22A6 | 9356 | 6 | 5 | 19 | |
| GSE43470 | SLC22A6 | 9356 | 1 | 6 | 36 | |
| GSE46452 | SLC22A6 | 9356 | 8 | 4 | 47 | |
| GSE47630 | SLC22A6 | 9356 | 3 | 7 | 30 | |
| GSE54993 | SLC22A6 | 9356 | 3 | 0 | 67 | |
| GSE54994 | SLC22A6 | 9356 | 5 | 5 | 43 | |
| GSE60625 | SLC22A6 | 9356 | 0 | 3 | 8 | |
| GSE74703 | SLC22A6 | 9356 | 1 | 3 | 32 | |
| GSE74704 | SLC22A6 | 9356 | 4 | 3 | 13 | |
| TCGA | SLC22A6 | 9356 | 17 | 11 | 68 |
Total number of gains: 54; Total number of losses: 52; Total Number of normals: 382.
Somatic mutations of SLC22A6:
Generating mutation plots.
Highly correlated genes for SLC22A6:
Showing top 20/415 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC22A6 | RBBP8NL | 0.733367 | 3 | 0 | 3 |
| SLC22A6 | MIR146A | 0.706111 | 3 | 0 | 3 |
| SLC22A6 | SIK1 | 0.699216 | 3 | 0 | 3 |
| SLC22A6 | SLC6A18 | 0.677692 | 3 | 0 | 3 |
| SLC22A6 | PGP | 0.677151 | 3 | 0 | 3 |
| SLC22A6 | SLC32A1 | 0.67401 | 3 | 0 | 3 |
| SLC22A6 | MCEMP1 | 0.672339 | 3 | 0 | 3 |
| SLC22A6 | TFEB | 0.666689 | 3 | 0 | 3 |
| SLC22A6 | C1orf158 | 0.666319 | 3 | 0 | 3 |
| SLC22A6 | LINC00544 | 0.665584 | 4 | 0 | 4 |
| SLC22A6 | PSPN | 0.662877 | 5 | 0 | 5 |
| SLC22A6 | CCL7 | 0.660974 | 3 | 0 | 3 |
| SLC22A6 | KLF16 | 0.660363 | 4 | 0 | 3 |
| SLC22A6 | LRRC46 | 0.659387 | 3 | 0 | 3 |
| SLC22A6 | PGLYRP2 | 0.65553 | 4 | 0 | 4 |
| SLC22A6 | C2orf73 | 0.653184 | 3 | 0 | 3 |
| SLC22A6 | TAB1 | 0.647948 | 3 | 0 | 3 |
| SLC22A6 | FLT4 | 0.647751 | 4 | 0 | 3 |
| SLC22A6 | NOXO1 | 0.646069 | 3 | 0 | 3 |
| SLC22A6 | MAPK15 | 0.643046 | 3 | 0 | 3 |
For details and further investigation, click here
