| Full name: G protein-coupled receptor kinase 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q26.11 | ||
| Entrez ID: 2869 | HGNC ID: HGNC:4544 | Ensembl Gene: ENSG00000198873 | OMIM ID: 600870 |
| Drug and gene relationship at DGIdb | |||
GRK5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa05032 | Morphine addiction |
Expression of GRK5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRK5 | 2869 | 204396_s_at | -0.8949 | 0.0933 | |
| GSE20347 | GRK5 | 2869 | 204396_s_at | 0.0887 | 0.7549 | |
| GSE23400 | GRK5 | 2869 | 204395_s_at | -0.0458 | 0.3300 | |
| GSE26886 | GRK5 | 2869 | 1569949_at | -0.4033 | 0.0005 | |
| GSE29001 | GRK5 | 2869 | 204396_s_at | 0.0416 | 0.9207 | |
| GSE38129 | GRK5 | 2869 | 204396_s_at | -0.4512 | 0.1815 | |
| GSE45670 | GRK5 | 2869 | 204396_s_at | -0.5567 | 0.1517 | |
| GSE63941 | GRK5 | 2869 | 204396_s_at | -4.2824 | 0.0002 | |
| GSE77861 | GRK5 | 2869 | 1569949_at | -0.4462 | 0.0015 | |
| GSE97050 | GRK5 | 2869 | A_23_P12884 | 0.2516 | 0.4175 | |
| SRP007169 | GRK5 | 2869 | RNAseq | 2.3455 | 0.0002 | |
| SRP064894 | GRK5 | 2869 | RNAseq | -0.0948 | 0.7368 | |
| SRP133303 | GRK5 | 2869 | RNAseq | -0.4244 | 0.0386 | |
| SRP159526 | GRK5 | 2869 | RNAseq | 0.2710 | 0.5303 | |
| SRP193095 | GRK5 | 2869 | RNAseq | 0.3174 | 0.3023 | |
| SRP219564 | GRK5 | 2869 | RNAseq | 0.0071 | 0.9924 | |
| TCGA | GRK5 | 2869 | RNAseq | -0.5778 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by GRK5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GRK5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRK5 | 2869 | 2 | 8 | 20 | |
| GSE20123 | GRK5 | 2869 | 2 | 8 | 20 | |
| GSE43470 | GRK5 | 2869 | 0 | 9 | 34 | |
| GSE46452 | GRK5 | 2869 | 0 | 11 | 48 | |
| GSE47630 | GRK5 | 2869 | 2 | 14 | 24 | |
| GSE54993 | GRK5 | 2869 | 8 | 0 | 62 | |
| GSE54994 | GRK5 | 2869 | 1 | 9 | 43 | |
| GSE60625 | GRK5 | 2869 | 0 | 0 | 11 | |
| GSE74703 | GRK5 | 2869 | 0 | 6 | 30 | |
| GSE74704 | GRK5 | 2869 | 1 | 3 | 16 | |
| TCGA | GRK5 | 2869 | 4 | 28 | 64 |
Total number of gains: 20; Total number of losses: 96; Total Number of normals: 372.
Somatic mutations of GRK5:
Generating mutation plots.
Highly correlated genes for GRK5:
Showing top 20/659 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRK5 | MAGI2-AS3 | 0.778997 | 3 | 0 | 3 |
| GRK5 | NLGN4X | 0.777019 | 3 | 0 | 3 |
| GRK5 | ST6GALNAC3 | 0.773383 | 4 | 0 | 4 |
| GRK5 | TSC22D3 | 0.771448 | 3 | 0 | 3 |
| GRK5 | TEK | 0.770534 | 5 | 0 | 5 |
| GRK5 | ZNF132 | 0.755834 | 3 | 0 | 3 |
| GRK5 | LRRN4CL | 0.741671 | 4 | 0 | 4 |
| GRK5 | ZNF582 | 0.741497 | 4 | 0 | 4 |
| GRK5 | CRISP3 | 0.739916 | 3 | 0 | 3 |
| GRK5 | KDM5D | 0.729509 | 4 | 0 | 4 |
| GRK5 | LRRK2 | 0.72935 | 5 | 0 | 5 |
| GRK5 | SOCS2 | 0.726207 | 3 | 0 | 3 |
| GRK5 | FAM214A | 0.724503 | 3 | 0 | 3 |
| GRK5 | PHYHD1 | 0.724409 | 4 | 0 | 4 |
| GRK5 | NAALADL1 | 0.724063 | 5 | 0 | 5 |
| GRK5 | FIBIN | 0.723432 | 5 | 0 | 5 |
| GRK5 | ST6GALNAC6 | 0.723222 | 3 | 0 | 3 |
| GRK5 | VPS37B | 0.722575 | 3 | 0 | 3 |
| GRK5 | SGCD | 0.721209 | 6 | 0 | 5 |
| GRK5 | THSD7A | 0.721195 | 4 | 0 | 4 |
For details and further investigation, click here
