| Full name: suppressor of cytokine signaling 2 | Alias Symbol: STATI2|SSI2|SOCS-2|SSI-2|CIS2|Cish2 | ||
| Type: protein-coding gene | Cytoband: 12q | ||
| Entrez ID: 8835 | HGNC ID: HGNC:19382 | Ensembl Gene: ENSG00000120833 | OMIM ID: 605117 |
| Drug and gene relationship at DGIdb | |||
SOCS2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa04917 | Prolactin signaling pathway | |
| hsa04930 | Type II diabetes mellitus |
Expression of SOCS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOCS2 | 8835 | 203373_at | -1.5926 | 0.0543 | |
| GSE20347 | SOCS2 | 8835 | 203373_at | -0.5149 | 0.0092 | |
| GSE23400 | SOCS2 | 8835 | 203373_at | -0.0606 | 0.6227 | |
| GSE26886 | SOCS2 | 8835 | 203373_at | -0.3085 | 0.5112 | |
| GSE29001 | SOCS2 | 8835 | 203373_at | -1.0864 | 0.0133 | |
| GSE38129 | SOCS2 | 8835 | 203373_at | -0.7558 | 0.0014 | |
| GSE45670 | SOCS2 | 8835 | 203373_at | -1.1677 | 0.0002 | |
| GSE53622 | SOCS2 | 8835 | 58312 | -1.3876 | 0.0000 | |
| GSE53624 | SOCS2 | 8835 | 58312 | -1.0845 | 0.0000 | |
| GSE63941 | SOCS2 | 8835 | 203373_at | -0.1266 | 0.9294 | |
| GSE77861 | SOCS2 | 8835 | 203373_at | 0.4971 | 0.4885 | |
| GSE97050 | SOCS2 | 8835 | A_23_P128215 | -0.2871 | 0.2417 | |
| SRP007169 | SOCS2 | 8835 | RNAseq | -0.1088 | 0.8722 | |
| SRP008496 | SOCS2 | 8835 | RNAseq | -0.4152 | 0.3861 | |
| SRP064894 | SOCS2 | 8835 | RNAseq | -0.6275 | 0.0373 | |
| SRP133303 | SOCS2 | 8835 | RNAseq | -0.1655 | 0.5978 | |
| SRP159526 | SOCS2 | 8835 | RNAseq | -0.9075 | 0.0387 | |
| SRP193095 | SOCS2 | 8835 | RNAseq | 0.2098 | 0.4202 | |
| SRP219564 | SOCS2 | 8835 | RNAseq | -0.3439 | 0.5661 | |
| TCGA | SOCS2 | 8835 | RNAseq | -0.6425 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by SOCS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOCS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOCS2 | 8835 | 3 | 2 | 25 | |
| GSE20123 | SOCS2 | 8835 | 3 | 2 | 25 | |
| GSE43470 | SOCS2 | 8835 | 3 | 0 | 40 | |
| GSE46452 | SOCS2 | 8835 | 9 | 1 | 49 | |
| GSE47630 | SOCS2 | 8835 | 10 | 1 | 29 | |
| GSE54993 | SOCS2 | 8835 | 0 | 5 | 65 | |
| GSE54994 | SOCS2 | 8835 | 5 | 2 | 46 | |
| GSE60625 | SOCS2 | 8835 | 0 | 0 | 11 | |
| GSE74703 | SOCS2 | 8835 | 3 | 0 | 33 | |
| GSE74704 | SOCS2 | 8835 | 1 | 2 | 17 | |
| TCGA | SOCS2 | 8835 | 17 | 11 | 68 |
Total number of gains: 54; Total number of losses: 26; Total Number of normals: 408.
Somatic mutations of SOCS2:
Generating mutation plots.
Highly correlated genes for SOCS2:
Showing top 20/879 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOCS2 | AKIRIN1 | 0.779679 | 3 | 0 | 3 |
| SOCS2 | FAM120AOS | 0.77829 | 3 | 0 | 3 |
| SOCS2 | ANKRD13A | 0.757649 | 3 | 0 | 3 |
| SOCS2 | CEP44 | 0.756881 | 3 | 0 | 3 |
| SOCS2 | TMEM132C | 0.754353 | 3 | 0 | 3 |
| SOCS2 | MAP4 | 0.754041 | 3 | 0 | 3 |
| SOCS2 | C11orf96 | 0.752854 | 3 | 0 | 3 |
| SOCS2 | TMEM219 | 0.751539 | 3 | 0 | 3 |
| SOCS2 | ARSG | 0.747173 | 3 | 0 | 3 |
| SOCS2 | RNASE4 | 0.74604 | 4 | 0 | 4 |
| SOCS2 | GPIHBP1 | 0.742786 | 3 | 0 | 3 |
| SOCS2 | SOCS2-AS1 | 0.741709 | 5 | 0 | 5 |
| SOCS2 | RPGR | 0.738807 | 3 | 0 | 3 |
| SOCS2 | GGA3 | 0.731194 | 3 | 0 | 3 |
| SOCS2 | GRK5 | 0.726207 | 3 | 0 | 3 |
| SOCS2 | FBXO8 | 0.726139 | 4 | 0 | 4 |
| SOCS2 | HBP1 | 0.721837 | 3 | 0 | 3 |
| SOCS2 | USP54 | 0.719198 | 4 | 0 | 3 |
| SOCS2 | RASSF3 | 0.717188 | 4 | 0 | 4 |
| SOCS2 | SOCS6 | 0.716682 | 4 | 0 | 4 |
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