Full name: TEK receptor tyrosine kinase	Alias Symbol: TIE2|TIE-2|VMCM1|CD202b
Type: protein-coding gene	Cytoband: 9p21.2
Entrez ID: 7010	HGNC ID: HGNC:11724	Ensembl Gene: ENSG00000120156	OMIM ID: 600221
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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TEK involved pathways:

KEGG pathway	Description	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View

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Expression of TEK:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	TEK	7010	206702_at	-0.7717	0.1550	Show
GSE20347	TEK	7010	206702_at	-0.3799	0.0008	Show
GSE23400	TEK	7010	217711_at	-0.0717	0.0445	Show
GSE26886	TEK	7010	217711_at	0.1576	0.2665	Show
GSE29001	TEK	7010	217711_at	-0.2430	0.2693	Show
GSE38129	TEK	7010	206702_at	-0.7824	0.0044	Show
GSE45670	TEK	7010	206702_at	-1.4103	0.0009	Show
GSE53622	TEK	7010	8957	-1.0430	0.0000	Show
GSE53624	TEK	7010	8957	-0.8021	0.0000	Show
GSE63941	TEK	7010	217711_at	0.0448	0.8240	Show
GSE77861	TEK	7010	217711_at	-0.0306	0.8446	Show
GSE97050	TEK	7010	A_23_P374695	0.0008	0.9975	Show
SRP007169	TEK	7010	RNAseq	1.2144	0.0876	Show
SRP064894	TEK	7010	RNAseq	0.0104	0.9783	Show
SRP133303	TEK	7010	RNAseq	-1.0494	0.0001	Show
SRP159526	TEK	7010	RNAseq	-0.1898	0.7347	Show
SRP193095	TEK	7010	RNAseq	0.2259	0.4045	Show
SRP219564	TEK	7010	RNAseq	-0.3671	0.5520	Show
TCGA	TEK	7010	RNAseq	-0.8100	0.0000	Show

Upregulated datasets: 0; Downregulated datasets: 3.  Download Data

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Survival by TEK expression:

 

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Copy number change of TEK:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	TEK	7010	2	14	14	Show
GSE20123	TEK	7010	2	14	14	Show
GSE43470	TEK	7010	2	11	30	Show
GSE46452	TEK	7010	6	18	35	Show
GSE47630	TEK	7010	1	22	17	Show
GSE54993	TEK	7010	7	0	63	Show
GSE54994	TEK	7010	7	15	31	Show
GSE60625	TEK	7010	0	0	11	Show
GSE74703	TEK	7010	2	8	26	Show
GSE74704	TEK	7010	0	11	9	Show
TCGA	TEK	7010	15	46	35	Show

Total number of gains: 44; Total number of losses: 159; Total Number of normals: 285.  Download Data

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Somatic mutations of TEK:

 

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Highly correlated genes for TEK:

 

Showing top 20/867 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
TEK	ACKR1	0.833269	6	0	6
TEK	JAM2	0.813005	6	0	6
TEK	EBF1	0.811463	5	0	5
TEK	LAMA2	0.783901	5	0	5
TEK	DDR2	0.777434	5	0	5
TEK	CNRIP1	0.77679	5	0	4
TEK	ECSCR	0.774279	6	0	5
TEK	GRK5	0.770534	5	0	5
TEK	MMRN1	0.761747	6	0	5
TEK	ST6GALNAC3	0.760031	6	0	6
TEK	CLDN5	0.756058	8	0	7
TEK	ITM2A	0.751504	7	0	7
TEK	TMEM47	0.751346	5	0	5
TEK	THSD7A	0.747915	8	0	8
TEK	TMEM100	0.747065	7	0	6
TEK	CCPG1	0.746162	3	0	3
TEK	TUBA1A	0.744885	3	0	3
TEK	GNG11	0.737383	8	0	6
TEK	IFNA5	0.734684	3	0	3
TEK	PDE1A	0.733472	7	0	6

For details and further investigation, click here