| Full name: leucine rich repeat kinase 2 | Alias Symbol: ROCO2|DKFZp434H2111|FLJ45829|RIPK7 | ||
| Type: protein-coding gene | Cytoband: 12q12 | ||
| Entrez ID: 120892 | HGNC ID: HGNC:18618 | Ensembl Gene: ENSG00000188906 | OMIM ID: 609007 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LRRK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRK2 | 120892 | 229584_at | -1.3503 | 0.1886 | |
| GSE26886 | LRRK2 | 120892 | 229584_at | -0.8725 | 0.0000 | |
| GSE45670 | LRRK2 | 120892 | 229584_at | -1.9045 | 0.0000 | |
| GSE53622 | LRRK2 | 120892 | 38730 | -2.5500 | 0.0000 | |
| GSE53624 | LRRK2 | 120892 | 38730 | -2.6158 | 0.0000 | |
| GSE63941 | LRRK2 | 120892 | 229584_at | -3.9186 | 0.0000 | |
| GSE77861 | LRRK2 | 120892 | 229584_at | -0.6928 | 0.0080 | |
| GSE97050 | LRRK2 | 120892 | A_33_P3389872 | -0.6289 | 0.1808 | |
| SRP007169 | LRRK2 | 120892 | RNAseq | -2.1444 | 0.0002 | |
| SRP008496 | LRRK2 | 120892 | RNAseq | -2.0837 | 0.0000 | |
| SRP064894 | LRRK2 | 120892 | RNAseq | -1.9231 | 0.0000 | |
| SRP133303 | LRRK2 | 120892 | RNAseq | -1.2244 | 0.0001 | |
| SRP159526 | LRRK2 | 120892 | RNAseq | -1.8085 | 0.0017 | |
| SRP193095 | LRRK2 | 120892 | RNAseq | -1.2389 | 0.0000 | |
| SRP219564 | LRRK2 | 120892 | RNAseq | -1.2273 | 0.0646 | |
| TCGA | LRRK2 | 120892 | RNAseq | -0.5250 | 0.0153 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by LRRK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRK2 | 120892 | 5 | 1 | 24 | |
| GSE20123 | LRRK2 | 120892 | 5 | 1 | 24 | |
| GSE43470 | LRRK2 | 120892 | 4 | 4 | 35 | |
| GSE46452 | LRRK2 | 120892 | 8 | 1 | 50 | |
| GSE47630 | LRRK2 | 120892 | 11 | 2 | 27 | |
| GSE54993 | LRRK2 | 120892 | 1 | 8 | 61 | |
| GSE54994 | LRRK2 | 120892 | 7 | 1 | 45 | |
| GSE60625 | LRRK2 | 120892 | 0 | 0 | 11 | |
| GSE74703 | LRRK2 | 120892 | 4 | 2 | 30 | |
| GSE74704 | LRRK2 | 120892 | 2 | 1 | 17 | |
| TCGA | LRRK2 | 120892 | 18 | 14 | 64 |
Total number of gains: 65; Total number of losses: 35; Total Number of normals: 388.
Somatic mutations of LRRK2:
Generating mutation plots.
Highly correlated genes for LRRK2:
Showing top 20/1657 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRK2 | AFF3 | 0.875594 | 3 | 0 | 3 |
| LRRK2 | BMPR2 | 0.838429 | 3 | 0 | 3 |
| LRRK2 | GPD1L | 0.830304 | 7 | 0 | 7 |
| LRRK2 | NLGN4Y | 0.821874 | 3 | 0 | 3 |
| LRRK2 | EIF4E3 | 0.819897 | 7 | 0 | 7 |
| LRRK2 | CLEC3B | 0.813265 | 3 | 0 | 3 |
| LRRK2 | SLC27A6 | 0.808029 | 7 | 0 | 7 |
| LRRK2 | SORT1 | 0.801739 | 7 | 0 | 7 |
| LRRK2 | TCF21 | 0.797019 | 6 | 0 | 6 |
| LRRK2 | RCAN2 | 0.796248 | 6 | 0 | 6 |
| LRRK2 | METTL7A | 0.793142 | 7 | 0 | 7 |
| LRRK2 | SLC4A4 | 0.792746 | 6 | 0 | 6 |
| LRRK2 | RAB8B | 0.791023 | 3 | 0 | 3 |
| LRRK2 | CGNL1 | 0.790361 | 7 | 0 | 7 |
| LRRK2 | ABCA8 | 0.789321 | 7 | 0 | 7 |
| LRRK2 | RBM20 | 0.784939 | 5 | 0 | 5 |
| LRRK2 | SNX25 | 0.784472 | 3 | 0 | 3 |
| LRRK2 | KAT2B | 0.784319 | 8 | 0 | 8 |
| LRRK2 | FAM8A1 | 0.781104 | 5 | 0 | 5 |
| LRRK2 | HGF | 0.780548 | 3 | 0 | 3 |
For details and further investigation, click here
