| Full name: VPS37B subunit of ESCRT-I | Alias Symbol: FLJ12750 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 79720 | HGNC ID: HGNC:25754 | Ensembl Gene: ENSG00000139722 | OMIM ID: 610037 |
| Drug and gene relationship at DGIdb | |||
Expression of VPS37B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS37B | 79720 | 221704_s_at | -0.2594 | 0.7231 | |
| GSE20347 | VPS37B | 79720 | 221704_s_at | -1.4964 | 0.0000 | |
| GSE23400 | VPS37B | 79720 | 221704_s_at | -1.2883 | 0.0000 | |
| GSE26886 | VPS37B | 79720 | 221704_s_at | -1.3605 | 0.0000 | |
| GSE29001 | VPS37B | 79720 | 221704_s_at | -1.4859 | 0.0010 | |
| GSE38129 | VPS37B | 79720 | 221704_s_at | -1.1859 | 0.0000 | |
| GSE45670 | VPS37B | 79720 | 221704_s_at | -0.6013 | 0.0180 | |
| GSE53622 | VPS37B | 79720 | 30350 | -1.3838 | 0.0000 | |
| GSE53624 | VPS37B | 79720 | 30350 | -1.3869 | 0.0000 | |
| GSE63941 | VPS37B | 79720 | 221704_s_at | 0.3252 | 0.5244 | |
| GSE77861 | VPS37B | 79720 | 221704_s_at | -0.8956 | 0.0026 | |
| GSE97050 | VPS37B | 79720 | A_23_P150876 | -0.5213 | 0.1637 | |
| SRP007169 | VPS37B | 79720 | RNAseq | -3.1196 | 0.0000 | |
| SRP008496 | VPS37B | 79720 | RNAseq | -2.8504 | 0.0000 | |
| SRP064894 | VPS37B | 79720 | RNAseq | -1.9049 | 0.0000 | |
| SRP133303 | VPS37B | 79720 | RNAseq | -1.5674 | 0.0000 | |
| SRP159526 | VPS37B | 79720 | RNAseq | -1.3305 | 0.0013 | |
| SRP193095 | VPS37B | 79720 | RNAseq | -1.4750 | 0.0000 | |
| SRP219564 | VPS37B | 79720 | RNAseq | -1.6826 | 0.0001 | |
| TCGA | VPS37B | 79720 | RNAseq | -0.2941 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by VPS37B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS37B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS37B | 79720 | 5 | 5 | 20 | |
| GSE20123 | VPS37B | 79720 | 5 | 5 | 20 | |
| GSE43470 | VPS37B | 79720 | 2 | 1 | 40 | |
| GSE46452 | VPS37B | 79720 | 9 | 1 | 49 | |
| GSE47630 | VPS37B | 79720 | 9 | 3 | 28 | |
| GSE54993 | VPS37B | 79720 | 0 | 5 | 65 | |
| GSE54994 | VPS37B | 79720 | 4 | 8 | 41 | |
| GSE60625 | VPS37B | 79720 | 0 | 0 | 11 | |
| GSE74703 | VPS37B | 79720 | 2 | 0 | 34 | |
| GSE74704 | VPS37B | 79720 | 3 | 3 | 14 | |
| TCGA | VPS37B | 79720 | 21 | 11 | 64 |
Total number of gains: 60; Total number of losses: 42; Total Number of normals: 386.
Somatic mutations of VPS37B:
Generating mutation plots.
Highly correlated genes for VPS37B:
Showing top 20/1640 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS37B | MXD1 | 0.818903 | 9 | 0 | 9 |
| VPS37B | TYSND1 | 0.811107 | 3 | 0 | 3 |
| VPS37B | PRSS3 | 0.809876 | 9 | 0 | 9 |
| VPS37B | EPS8L1 | 0.805401 | 11 | 0 | 11 |
| VPS37B | LRRFIP2 | 0.797656 | 10 | 0 | 10 |
| VPS37B | SPINK5 | 0.795126 | 9 | 0 | 9 |
| VPS37B | SLC16A6 | 0.792692 | 10 | 0 | 10 |
| VPS37B | EVPL | 0.789267 | 11 | 0 | 10 |
| VPS37B | PLEKHM1 | 0.787253 | 11 | 0 | 10 |
| VPS37B | TPCN1 | 0.786658 | 11 | 0 | 10 |
| VPS37B | LRP10 | 0.783129 | 10 | 0 | 10 |
| VPS37B | CXCR2 | 0.782947 | 10 | 0 | 10 |
| VPS37B | C18orf25 | 0.782357 | 11 | 0 | 11 |
| VPS37B | ANXA11 | 0.781803 | 11 | 0 | 11 |
| VPS37B | SMAGP | 0.781005 | 10 | 0 | 10 |
| VPS37B | C5orf66-AS1 | 0.780877 | 6 | 0 | 6 |
| VPS37B | MFSD5 | 0.780032 | 11 | 0 | 11 |
| VPS37B | GYS2 | 0.778827 | 10 | 0 | 9 |
| VPS37B | USP6NL | 0.776245 | 11 | 0 | 11 |
| VPS37B | EPB41L3 | 0.773657 | 10 | 0 | 10 |
For details and further investigation, click here
