| Full name: multiple EGF like domains 10 | Alias Symbol: KIAA1780 | ||
| Type: protein-coding gene | Cytoband: 5q23.2 | ||
| Entrez ID: 84466 | HGNC ID: HGNC:29634 | Ensembl Gene: ENSG00000145794 | OMIM ID: 612453 |
| Drug and gene relationship at DGIdb | |||
Expression of MEGF10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEGF10 | 84466 | 1555343_at | 0.2473 | 0.2589 | |
| GSE26886 | MEGF10 | 84466 | 1555343_at | 0.1539 | 0.1873 | |
| GSE45670 | MEGF10 | 84466 | 1555343_at | 0.2692 | 0.0129 | |
| GSE53622 | MEGF10 | 84466 | 36110 | 0.6269 | 0.0276 | |
| GSE53624 | MEGF10 | 84466 | 36110 | 0.9088 | 0.0000 | |
| GSE63941 | MEGF10 | 84466 | 1555343_at | 0.4920 | 0.0041 | |
| GSE77861 | MEGF10 | 84466 | 1555343_at | 0.0213 | 0.8378 | |
| GSE97050 | MEGF10 | A_21_P0004292 | 0.1115 | 0.6223 | ||
| SRP133303 | MEGF10 | 84466 | RNAseq | 1.7101 | 0.0046 | |
| SRP159526 | MEGF10 | 84466 | RNAseq | 3.3245 | 0.0000 | |
| SRP219564 | MEGF10 | 84466 | RNAseq | 1.2020 | 0.1323 | |
| TCGA | MEGF10 | 84466 | RNAseq | 0.8110 | 0.0448 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MEGF10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEGF10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEGF10 | 84466 | 1 | 12 | 17 | |
| GSE20123 | MEGF10 | 84466 | 1 | 12 | 17 | |
| GSE43470 | MEGF10 | 84466 | 3 | 8 | 32 | |
| GSE46452 | MEGF10 | 84466 | 0 | 27 | 32 | |
| GSE47630 | MEGF10 | 84466 | 0 | 21 | 19 | |
| GSE54993 | MEGF10 | 84466 | 9 | 1 | 60 | |
| GSE54994 | MEGF10 | 84466 | 2 | 14 | 37 | |
| GSE60625 | MEGF10 | 84466 | 0 | 0 | 11 | |
| GSE74703 | MEGF10 | 84466 | 2 | 6 | 28 | |
| GSE74704 | MEGF10 | 84466 | 1 | 6 | 13 | |
| TCGA | MEGF10 | 84466 | 2 | 40 | 54 |
Total number of gains: 21; Total number of losses: 147; Total Number of normals: 320.
Somatic mutations of MEGF10:
Generating mutation plots.
Highly correlated genes for MEGF10:
Showing top 20/114 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEGF10 | ASPHD1 | 0.769792 | 3 | 0 | 3 |
| MEGF10 | WFDC6 | 0.755512 | 3 | 0 | 3 |
| MEGF10 | SLC6A13 | 0.750213 | 3 | 0 | 3 |
| MEGF10 | ELMO3 | 0.74189 | 3 | 0 | 3 |
| MEGF10 | DEFB123 | 0.738668 | 3 | 0 | 3 |
| MEGF10 | CRABP1 | 0.735808 | 3 | 0 | 3 |
| MEGF10 | GRM4 | 0.729695 | 3 | 0 | 3 |
| MEGF10 | SBNO2 | 0.719881 | 3 | 0 | 3 |
| MEGF10 | NEUROG1 | 0.718233 | 3 | 0 | 3 |
| MEGF10 | DPF1 | 0.707493 | 3 | 0 | 3 |
| MEGF10 | CDK16 | 0.701169 | 3 | 0 | 3 |
| MEGF10 | ZNF687 | 0.700233 | 3 | 0 | 3 |
| MEGF10 | DCAF15 | 0.699106 | 3 | 0 | 3 |
| MEGF10 | AQP4 | 0.696375 | 3 | 0 | 3 |
| MEGF10 | RNF44 | 0.69273 | 3 | 0 | 3 |
| MEGF10 | CELF3 | 0.691255 | 3 | 0 | 3 |
| MEGF10 | CNGB3 | 0.687314 | 3 | 0 | 3 |
| MEGF10 | BTBD8 | 0.686254 | 3 | 0 | 3 |
| MEGF10 | CACNG4 | 0.681941 | 3 | 0 | 3 |
| MEGF10 | TNFRSF25 | 0.681462 | 3 | 0 | 3 |
For details and further investigation, click here
