| Full name: granzyme H | Alias Symbol: CGL-2|CCP-X|CTLA1|CSP-C | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 2999 | HGNC ID: HGNC:4710 | Ensembl Gene: ENSG00000100450 | OMIM ID: 116831 |
| Drug and gene relationship at DGIdb | |||
Expression of GZMH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GZMH | 2999 | 210321_at | 0.4250 | 0.7208 | |
| GSE20347 | GZMH | 2999 | 210321_at | -0.1229 | 0.5123 | |
| GSE23400 | GZMH | 2999 | 210321_at | -0.0931 | 0.0728 | |
| GSE26886 | GZMH | 2999 | 210321_at | 0.0149 | 0.9546 | |
| GSE29001 | GZMH | 2999 | 210321_at | -0.1599 | 0.5567 | |
| GSE38129 | GZMH | 2999 | 210321_at | -0.2443 | 0.2037 | |
| GSE45670 | GZMH | 2999 | 210321_at | -0.3578 | 0.3117 | |
| GSE63941 | GZMH | 2999 | 210321_at | 0.4206 | 0.0082 | |
| GSE77861 | GZMH | 2999 | 210321_at | -0.0338 | 0.8028 | |
| GSE97050 | GZMH | 2999 | A_23_P128993 | 0.1183 | 0.7337 | |
| SRP133303 | GZMH | 2999 | RNAseq | 0.7704 | 0.1332 | |
| SRP159526 | GZMH | 2999 | RNAseq | -1.0544 | 0.2210 | |
| SRP219564 | GZMH | 2999 | RNAseq | 1.2520 | 0.0105 | |
| TCGA | GZMH | 2999 | RNAseq | 0.3447 | 0.3803 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GZMH expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GZMH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GZMH | 2999 | 8 | 3 | 19 | |
| GSE20123 | GZMH | 2999 | 8 | 3 | 19 | |
| GSE43470 | GZMH | 2999 | 8 | 2 | 33 | |
| GSE46452 | GZMH | 2999 | 16 | 2 | 41 | |
| GSE47630 | GZMH | 2999 | 11 | 10 | 19 | |
| GSE54993 | GZMH | 2999 | 3 | 11 | 56 | |
| GSE54994 | GZMH | 2999 | 18 | 5 | 30 | |
| GSE60625 | GZMH | 2999 | 0 | 2 | 9 | |
| GSE74703 | GZMH | 2999 | 7 | 2 | 27 | |
| GSE74704 | GZMH | 2999 | 3 | 2 | 15 | |
| TCGA | GZMH | 2999 | 27 | 12 | 57 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of GZMH:
Generating mutation plots.
Highly correlated genes for GZMH:
Showing top 20/88 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GZMH | PDIA2 | 0.774798 | 3 | 0 | 3 |
| GZMH | BTBD19 | 0.736941 | 3 | 0 | 3 |
| GZMH | GRM4 | 0.723906 | 3 | 0 | 3 |
| GZMH | BTNL9 | 0.722336 | 3 | 0 | 3 |
| GZMH | JAKMIP1 | 0.713302 | 3 | 0 | 3 |
| GZMH | NPPB | 0.712935 | 3 | 0 | 3 |
| GZMH | TNFRSF25 | 0.70999 | 3 | 0 | 3 |
| GZMH | MEGF11 | 0.704697 | 3 | 0 | 3 |
| GZMH | AGAP2 | 0.699578 | 3 | 0 | 3 |
| GZMH | CD8A | 0.693739 | 9 | 0 | 8 |
| GZMH | HCST | 0.688408 | 4 | 0 | 4 |
| GZMH | TP73 | 0.683346 | 4 | 0 | 4 |
| GZMH | IL2RB | 0.678003 | 6 | 0 | 6 |
| GZMH | PRF1 | 0.670991 | 10 | 0 | 8 |
| GZMH | IL10RA | 0.640174 | 9 | 0 | 8 |
| GZMH | LIME1 | 0.637197 | 4 | 0 | 3 |
| GZMH | RAX2 | 0.636754 | 3 | 0 | 3 |
| GZMH | LAG3 | 0.6318 | 9 | 0 | 8 |
| GZMH | C10orf67 | 0.620309 | 3 | 0 | 3 |
| GZMH | MFNG | 0.616194 | 6 | 0 | 4 |
For details and further investigation, click here
