| Full name: gamma-secretase activating protein | Alias Symbol: LOC54103 | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 54103 | HGNC ID: HGNC:28042 | Ensembl Gene: ENSG00000186088 | OMIM ID: 613552 |
| Drug and gene relationship at DGIdb | |||
Expression of GSAP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GSAP | 54103 | 213142_x_at | -0.1104 | 0.9228 | |
| GSE20347 | GSAP | 54103 | 213142_x_at | -0.0271 | 0.9416 | |
| GSE23400 | GSAP | 54103 | 213142_x_at | 0.2520 | 0.0787 | |
| GSE26886 | GSAP | 54103 | 222150_s_at | 0.6572 | 0.2029 | |
| GSE29001 | GSAP | 54103 | 222150_s_at | 0.2297 | 0.7070 | |
| GSE38129 | GSAP | 54103 | 213142_x_at | 0.0541 | 0.8297 | |
| GSE45670 | GSAP | 54103 | 213142_x_at | -0.0198 | 0.9624 | |
| GSE53622 | GSAP | 54103 | 5380 | 0.3644 | 0.0035 | |
| GSE53624 | GSAP | 54103 | 5380 | 0.1828 | 0.0636 | |
| GSE63941 | GSAP | 54103 | 213142_x_at | -0.5481 | 0.6513 | |
| GSE77861 | GSAP | 54103 | 213142_x_at | 0.8829 | 0.0860 | |
| SRP007169 | GSAP | 54103 | RNAseq | 0.6428 | 0.2626 | |
| SRP008496 | GSAP | 54103 | RNAseq | 1.7119 | 0.0010 | |
| SRP064894 | GSAP | 54103 | RNAseq | 0.2520 | 0.2967 | |
| SRP133303 | GSAP | 54103 | RNAseq | 0.3288 | 0.2299 | |
| SRP159526 | GSAP | 54103 | RNAseq | 0.2212 | 0.6414 | |
| SRP193095 | GSAP | 54103 | RNAseq | 0.4347 | 0.0077 | |
| SRP219564 | GSAP | 54103 | RNAseq | 0.7109 | 0.0037 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GSAP expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of GSAP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GSAP | 54103 | 15 | 1 | 14 | |
| GSE20123 | GSAP | 54103 | 15 | 1 | 14 | |
| GSE43470 | GSAP | 54103 | 4 | 1 | 38 | |
| GSE46452 | GSAP | 54103 | 11 | 0 | 48 | |
| GSE47630 | GSAP | 54103 | 7 | 3 | 30 | |
| GSE54993 | GSAP | 54103 | 1 | 7 | 62 | |
| GSE54994 | GSAP | 54103 | 15 | 3 | 35 | |
| GSE60625 | GSAP | 54103 | 0 | 0 | 11 | |
| GSE74703 | GSAP | 54103 | 3 | 1 | 32 | |
| GSE74704 | GSAP | 54103 | 8 | 1 | 11 | |
| TCGA | GSAP | 54103 | 44 | 5 | 47 |
Total number of gains: 123; Total number of losses: 23; Total Number of normals: 342.
Somatic mutations of GSAP:
Generating mutation plots.
Highly correlated genes for GSAP:
Showing top 20/26 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GSAP | IRX4 | 0.670157 | 3 | 0 | 3 |
| GSAP | LPP-AS2 | 0.666305 | 3 | 0 | 3 |
| GSAP | RAD51-AS1 | 0.656753 | 4 | 0 | 3 |
| GSAP | STOX2 | 0.632302 | 3 | 0 | 3 |
| GSAP | ELOVL7 | 0.627789 | 3 | 0 | 3 |
| GSAP | CEP95 | 0.60918 | 3 | 0 | 3 |
| GSAP | PIGG | 0.605623 | 6 | 0 | 5 |
| GSAP | DGKH | 0.575593 | 4 | 0 | 3 |
| GSAP | CUL4A | 0.57151 | 3 | 0 | 3 |
| GSAP | PIK3CD | 0.56983 | 4 | 0 | 3 |
| GSAP | SPR | 0.568603 | 3 | 0 | 3 |
| GSAP | LINC00173 | 0.563833 | 4 | 0 | 3 |
| GSAP | ASPH | 0.560337 | 4 | 0 | 3 |
| GSAP | TGOLN2 | 0.553779 | 6 | 0 | 3 |
| GSAP | POLG2 | 0.549235 | 4 | 0 | 3 |
| GSAP | EGR2 | 0.545338 | 3 | 0 | 3 |
| GSAP | ROCK2 | 0.539569 | 5 | 0 | 4 |
| GSAP | INPP5E | 0.535695 | 5 | 0 | 4 |
| GSAP | PKD2 | 0.53408 | 4 | 0 | 3 |
| GSAP | VWA8 | 0.533032 | 5 | 0 | 3 |
For details and further investigation, click here
