| Full name: sepiapterin reductase | Alias Symbol: SDR38C1 | ||
| Type: protein-coding gene | Cytoband: 2p13.2 | ||
| Entrez ID: 6697 | HGNC ID: HGNC:11257 | Ensembl Gene: ENSG00000116096 | OMIM ID: 182125 |
| Drug and gene relationship at DGIdb | |||
Expression of SPR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPR | 6697 | 203458_at | 0.4181 | 0.3004 | |
| GSE20347 | SPR | 6697 | 203458_at | 0.6527 | 0.0000 | |
| GSE23400 | SPR | 6697 | 203458_at | 0.2413 | 0.0000 | |
| GSE26886 | SPR | 6697 | 203458_at | 0.1056 | 0.6226 | |
| GSE29001 | SPR | 6697 | 203458_at | 0.2879 | 0.1214 | |
| GSE38129 | SPR | 6697 | 203458_at | 0.5821 | 0.0000 | |
| GSE45670 | SPR | 6697 | 203458_at | 0.5262 | 0.0003 | |
| GSE53622 | SPR | 6697 | 89458 | 0.5152 | 0.0000 | |
| GSE53624 | SPR | 6697 | 89458 | 0.6832 | 0.0000 | |
| GSE63941 | SPR | 6697 | 203458_at | 0.3148 | 0.3604 | |
| GSE77861 | SPR | 6697 | 203458_at | 0.3243 | 0.1114 | |
| GSE97050 | SPR | 6697 | A_23_P68211 | -0.1327 | 0.7345 | |
| SRP007169 | SPR | 6697 | RNAseq | 1.3312 | 0.0492 | |
| SRP064894 | SPR | 6697 | RNAseq | 0.8645 | 0.0076 | |
| SRP133303 | SPR | 6697 | RNAseq | 0.8536 | 0.0000 | |
| SRP159526 | SPR | 6697 | RNAseq | 1.2274 | 0.0001 | |
| SRP193095 | SPR | 6697 | RNAseq | 0.4728 | 0.0192 | |
| SRP219564 | SPR | 6697 | RNAseq | 0.7487 | 0.2030 | |
| TCGA | SPR | 6697 | RNAseq | -0.0799 | 0.3064 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPR | 6697 | 11 | 1 | 18 | |
| GSE20123 | SPR | 6697 | 11 | 1 | 18 | |
| GSE43470 | SPR | 6697 | 3 | 0 | 40 | |
| GSE46452 | SPR | 6697 | 2 | 3 | 54 | |
| GSE47630 | SPR | 6697 | 7 | 0 | 33 | |
| GSE54993 | SPR | 6697 | 0 | 6 | 64 | |
| GSE54994 | SPR | 6697 | 11 | 0 | 42 | |
| GSE60625 | SPR | 6697 | 0 | 3 | 8 | |
| GSE74703 | SPR | 6697 | 3 | 0 | 33 | |
| GSE74704 | SPR | 6697 | 9 | 0 | 11 | |
| TCGA | SPR | 6697 | 38 | 2 | 56 |
Total number of gains: 95; Total number of losses: 16; Total Number of normals: 377.
Somatic mutations of SPR:
Generating mutation plots.
Highly correlated genes for SPR:
Showing top 20/932 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPR | ANKRD10 | 0.743413 | 3 | 0 | 3 |
| SPR | FLNB | 0.716974 | 3 | 0 | 3 |
| SPR | TADA3 | 0.688511 | 3 | 0 | 3 |
| SPR | ALKBH6 | 0.688459 | 3 | 0 | 3 |
| SPR | ZC3H12C | 0.678802 | 4 | 0 | 3 |
| SPR | PACSIN3 | 0.675138 | 3 | 0 | 3 |
| SPR | CXCL16 | 0.671789 | 3 | 0 | 3 |
| SPR | FAM89B | 0.659192 | 4 | 0 | 3 |
| SPR | C11orf24 | 0.653946 | 8 | 0 | 7 |
| SPR | PSPC1 | 0.653882 | 4 | 0 | 4 |
| SPR | RTN4R | 0.652283 | 4 | 0 | 3 |
| SPR | PARL | 0.648688 | 11 | 0 | 11 |
| SPR | PARVB | 0.645502 | 7 | 0 | 6 |
| SPR | BOLA3 | 0.643044 | 7 | 0 | 5 |
| SPR | KLF13 | 0.643013 | 5 | 0 | 4 |
| SPR | BID | 0.640966 | 9 | 0 | 8 |
| SPR | FADD | 0.640542 | 5 | 0 | 4 |
| SPR | PMPCB | 0.640432 | 4 | 0 | 4 |
| SPR | B4GALNT3 | 0.640207 | 4 | 0 | 4 |
| SPR | CPT1A | 0.63906 | 5 | 0 | 3 |
For details and further investigation, click here
