POLG2

 

Full name: DNA polymerase gamma 2, accessory subunit Alias Symbol: MTPOLB|HP55
Type: protein-coding gene Cytoband: 17q23.3
Entrez ID: 11232 HGNC ID: HGNC:9180 Ensembl Gene: ENSG00000256525 OMIM ID: 604983
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of POLG2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLG2 11232 205811_at 0.2732 0.2532
GSE20347 POLG2 11232 205811_at 0.4696 0.0002
GSE23400 POLG2 11232 205811_at 0.2892 0.0000
GSE26886 POLG2 11232 205811_at 0.3537 0.0345
GSE29001 POLG2 11232 205811_at 0.3312 0.0646
GSE38129 POLG2 11232 205811_at 0.5049 0.0000
GSE45670 POLG2 11232 205811_at 0.1988 0.1995
GSE53622 POLG2 11232 101328 0.6119 0.0000
GSE53624 POLG2 11232 101328 0.5929 0.0000
GSE63941 POLG2 11232 205811_at 0.8751 0.0224
GSE77861 POLG2 11232 205811_at 0.2807 0.0732
GSE97050 POLG2 11232 A_23_P26905 0.5318 0.1453
SRP007169 POLG2 11232 RNAseq 0.2160 0.7482
SRP064894 POLG2 11232 RNAseq 0.5533 0.0000
SRP133303 POLG2 11232 RNAseq 0.2255 0.3352
SRP159526 POLG2 11232 RNAseq 0.7399 0.0064
SRP193095 POLG2 11232 RNAseq 0.1080 0.3785
SRP219564 POLG2 11232 RNAseq 0.5977 0.1395
TCGA POLG2 11232 RNAseq 0.2109 0.0077

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by POLG2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLG2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLG2 11232 3 1 26
GSE20123 POLG2 11232 3 1 26
GSE43470 POLG2 11232 5 0 38
GSE46452 POLG2 11232 32 0 27
GSE47630 POLG2 11232 7 1 32
GSE54993 POLG2 11232 2 5 63
GSE54994 POLG2 11232 9 4 40
GSE60625 POLG2 11232 4 0 7
GSE74703 POLG2 11232 5 0 31
GSE74704 POLG2 11232 3 1 16
TCGA POLG2 11232 30 8 58

Total number of gains: 103; Total number of losses: 21; Total Number of normals: 364.  

 

Somatic mutations of POLG2:

 

Generating mutation plots.

 

Highly correlated genes for POLG2:

 

Showing top 20/666 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLG2ZBP10.68828303
POLG2SMPD40.669781303
POLG2CA90.659514504
POLG2PABPC1L0.659115706
POLG2KLHL420.654056303
POLG2C1QTNF60.643828403
POLG2FEN10.639518707
POLG2GPR840.639045303
POLG2FRMD6-AS10.633754303
POLG2MCM70.6331831008
POLG2TMC80.633055403
POLG2KCNN40.632304303
POLG2HAUS80.631609605
POLG2PDIA60.63151707
POLG2SMYD50.631416404
POLG2BUB1B0.629044806
POLG2TK10.6265061008
POLG2CAD0.622186907
POLG2SALL40.621819504
POLG2NUP850.6216821008

For details and further investigation, click here