| Full name: iroquois homeobox 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 50805 | HGNC ID: HGNC:6129 | Ensembl Gene: ENSG00000113430 | OMIM ID: 606199 |
| Drug and gene relationship at DGIdb | |||
Expression of IRX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRX4 | 50805 | 220225_at | 0.1078 | 0.9561 | |
| GSE20347 | IRX4 | 50805 | 220225_at | 0.2945 | 0.4357 | |
| GSE23400 | IRX4 | 50805 | 220225_at | 0.4280 | 0.0006 | |
| GSE26886 | IRX4 | 50805 | 220225_at | 1.8702 | 0.0000 | |
| GSE29001 | IRX4 | 50805 | 220225_at | 0.2224 | 0.6126 | |
| GSE38129 | IRX4 | 50805 | 220225_at | 0.7003 | 0.0491 | |
| GSE45670 | IRX4 | 50805 | 220225_at | 0.5417 | 0.2278 | |
| GSE63941 | IRX4 | 50805 | 220225_at | 2.0720 | 0.0248 | |
| GSE77861 | IRX4 | 50805 | 220225_at | 0.2406 | 0.6553 | |
| GSE97050 | IRX4 | 50805 | A_23_P110837 | 1.0088 | 0.2211 | |
| SRP007169 | IRX4 | 50805 | RNAseq | 2.2942 | 0.0191 | |
| SRP064894 | IRX4 | 50805 | RNAseq | -0.8232 | 0.1610 | |
| SRP133303 | IRX4 | 50805 | RNAseq | 0.8223 | 0.0851 | |
| SRP219564 | IRX4 | 50805 | RNAseq | 1.4565 | 0.2754 | |
| TCGA | IRX4 | 50805 | RNAseq | 1.4945 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by IRX4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of IRX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRX4 | 50805 | 13 | 1 | 16 | |
| GSE20123 | IRX4 | 50805 | 13 | 1 | 16 | |
| GSE43470 | IRX4 | 50805 | 17 | 1 | 25 | |
| GSE46452 | IRX4 | 50805 | 6 | 22 | 31 | |
| GSE47630 | IRX4 | 50805 | 6 | 11 | 23 | |
| GSE54993 | IRX4 | 50805 | 5 | 5 | 60 | |
| GSE54994 | IRX4 | 50805 | 29 | 1 | 23 | |
| GSE60625 | IRX4 | 50805 | 0 | 0 | 11 | |
| GSE74703 | IRX4 | 50805 | 14 | 0 | 22 | |
| GSE74704 | IRX4 | 50805 | 11 | 0 | 9 | |
| TCGA | IRX4 | 50805 | 59 | 3 | 34 |
Total number of gains: 173; Total number of losses: 45; Total Number of normals: 270.
Somatic mutations of IRX4:
Generating mutation plots.
Highly correlated genes for IRX4:
Showing top 20/148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRX4 | C12orf75 | 0.745441 | 3 | 0 | 3 |
| IRX4 | GSAP | 0.670157 | 3 | 0 | 3 |
| IRX4 | PKN3 | 0.667106 | 4 | 0 | 4 |
| IRX4 | CPNE2 | 0.654593 | 3 | 0 | 3 |
| IRX4 | RUSC1-AS1 | 0.643977 | 3 | 0 | 3 |
| IRX4 | RAD52 | 0.637928 | 3 | 0 | 3 |
| IRX4 | CHST15 | 0.634804 | 3 | 0 | 3 |
| IRX4 | TNNT1 | 0.627918 | 4 | 0 | 3 |
| IRX4 | TENM4 | 0.625684 | 3 | 0 | 3 |
| IRX4 | MXRA5 | 0.622693 | 3 | 0 | 3 |
| IRX4 | MSN | 0.621681 | 3 | 0 | 3 |
| IRX4 | LAMA5 | 0.621305 | 4 | 0 | 4 |
| IRX4 | SDK2 | 0.620386 | 4 | 0 | 3 |
| IRX4 | ADAP2 | 0.619788 | 4 | 0 | 4 |
| IRX4 | FKBP9 | 0.615478 | 5 | 0 | 4 |
| IRX4 | BSG | 0.611802 | 4 | 0 | 4 |
| IRX4 | TNFAIP8L1 | 0.610516 | 4 | 0 | 3 |
| IRX4 | MISP | 0.606113 | 4 | 0 | 3 |
| IRX4 | GCNT1 | 0.602499 | 3 | 0 | 3 |
| IRX4 | SH3BP1 | 0.59865 | 5 | 0 | 4 |
For details and further investigation, click here
