ROCK2

 

Full name: Rho associated coiled-coil containing protein kinase 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 2p25.1
Entrez ID: 9475 HGNC ID: HGNC:10252 Ensembl Gene: ENSG00000134318 OMIM ID: 604002
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ROCK2 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa04921Oxytocin signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection
hsa05205Proteoglycans in cancer

 

Expression of ROCK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ROCK2 9475 202762_at -0.3225 0.5750
GSE20347 ROCK2 9475 202762_at 0.3195 0.1084
GSE23400 ROCK2 9475 211504_x_at -0.0020 0.9620
GSE26886 ROCK2 9475 202762_at -0.5358 0.0641
GSE29001 ROCK2 9475 202762_at 0.4988 0.1411
GSE38129 ROCK2 9475 202762_at 0.0258 0.9136
GSE45670 ROCK2 9475 202762_at -0.3392 0.0364
GSE53622 ROCK2 9475 121523 0.0733 0.4363
GSE53624 ROCK2 9475 121523 0.2224 0.0013
GSE63941 ROCK2 9475 202762_at -2.0652 0.0013
GSE77861 ROCK2 9475 202762_at 0.9781 0.0070
GSE97050 ROCK2 9475 A_33_P3257140 -0.2029 0.5157
SRP007169 ROCK2 9475 RNAseq 1.3841 0.0002
SRP008496 ROCK2 9475 RNAseq 1.6063 0.0000
SRP064894 ROCK2 9475 RNAseq -0.0911 0.6719
SRP133303 ROCK2 9475 RNAseq 0.2222 0.0680
SRP159526 ROCK2 9475 RNAseq 0.2023 0.3782
SRP193095 ROCK2 9475 RNAseq 0.2945 0.0384
SRP219564 ROCK2 9475 RNAseq -0.2901 0.4164
TCGA ROCK2 9475 RNAseq -0.1792 0.0019

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by ROCK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ROCK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ROCK2 9475 10 2 18
GSE20123 ROCK2 9475 10 2 18
GSE43470 ROCK2 9475 2 1 40
GSE46452 ROCK2 9475 3 4 52
GSE47630 ROCK2 9475 7 0 33
GSE54993 ROCK2 9475 0 7 63
GSE54994 ROCK2 9475 11 0 42
GSE60625 ROCK2 9475 0 3 8
GSE74703 ROCK2 9475 2 0 34
GSE74704 ROCK2 9475 9 1 10
TCGA ROCK2 9475 34 5 57

Total number of gains: 88; Total number of losses: 25; Total Number of normals: 375.  

 

Somatic mutations of ROCK2:

 

Generating mutation plots.

 

Highly correlated genes for ROCK2:

 

Showing top 20/689 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ROCK2CHL10.79853303
ROCK2AGL0.733847303
ROCK2PAAF10.723655303
ROCK2SH3D190.718658403
ROCK2PKD20.71447707
ROCK2RILPL20.713721303
ROCK2FGL20.711922404
ROCK2KDM1A0.705822404
ROCK2RSPO30.705403303
ROCK2PKIG0.701255707
ROCK2NKTR0.697185303
ROCK2DIS3L0.693543404
ROCK2DPYSL20.691999807
ROCK2KIF5B0.689511403
ROCK2PARK70.683743505
ROCK2FEM1C0.682282303
ROCK2SNX180.682249404
ROCK2TSNAX0.681141505
ROCK2ZNF7030.680953303
ROCK2CYP2U10.679701303

For details and further investigation, click here