| Full name: carbonyl reductase 1 | Alias Symbol: SDR21C1 | ||
| Type: protein-coding gene | Cytoband: 21q22.12 | ||
| Entrez ID: 873 | HGNC ID: HGNC:1548 | Ensembl Gene: ENSG00000159228 | OMIM ID: 114830 |
| Drug and gene relationship at DGIdb | |||
Expression of CBR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBR1 | 873 | 209213_at | 0.0777 | 0.8658 | |
| GSE20347 | CBR1 | 873 | 209213_at | -0.0643 | 0.8113 | |
| GSE23400 | CBR1 | 873 | 209213_at | 0.0763 | 0.6428 | |
| GSE26886 | CBR1 | 873 | 209213_at | -0.6543 | 0.1324 | |
| GSE29001 | CBR1 | 873 | 209213_at | -0.0328 | 0.9415 | |
| GSE38129 | CBR1 | 873 | 209213_at | 0.2718 | 0.3416 | |
| GSE45670 | CBR1 | 873 | 209213_at | 0.0870 | 0.7911 | |
| GSE53622 | CBR1 | 873 | 80110 | -0.4565 | 0.0016 | |
| GSE53624 | CBR1 | 873 | 80110 | -0.1520 | 0.1527 | |
| GSE63941 | CBR1 | 873 | 209213_at | -0.4362 | 0.7172 | |
| GSE77861 | CBR1 | 873 | 209213_at | -0.0101 | 0.9865 | |
| GSE97050 | CBR1 | 873 | A_23_P29046 | -0.4081 | 0.2417 | |
| SRP007169 | CBR1 | 873 | RNAseq | 0.1074 | 0.8577 | |
| SRP008496 | CBR1 | 873 | RNAseq | 0.2973 | 0.4712 | |
| SRP064894 | CBR1 | 873 | RNAseq | -0.3880 | 0.1229 | |
| SRP133303 | CBR1 | 873 | RNAseq | -0.6939 | 0.0266 | |
| SRP159526 | CBR1 | 873 | RNAseq | 1.0111 | 0.1272 | |
| SRP193095 | CBR1 | 873 | RNAseq | -0.5022 | 0.0714 | |
| SRP219564 | CBR1 | 873 | RNAseq | -0.0489 | 0.9166 | |
| TCGA | CBR1 | 873 | RNAseq | 0.0892 | 0.4216 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CBR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBR1 | 873 | 2 | 8 | 20 | |
| GSE20123 | CBR1 | 873 | 2 | 9 | 19 | |
| GSE43470 | CBR1 | 873 | 1 | 11 | 31 | |
| GSE46452 | CBR1 | 873 | 1 | 21 | 37 | |
| GSE47630 | CBR1 | 873 | 6 | 17 | 17 | |
| GSE54993 | CBR1 | 873 | 8 | 1 | 61 | |
| GSE54994 | CBR1 | 873 | 2 | 9 | 42 | |
| GSE60625 | CBR1 | 873 | 0 | 0 | 11 | |
| GSE74703 | CBR1 | 873 | 1 | 8 | 27 | |
| GSE74704 | CBR1 | 873 | 1 | 5 | 14 | |
| TCGA | CBR1 | 873 | 9 | 39 | 48 |
Total number of gains: 33; Total number of losses: 128; Total Number of normals: 327.
Somatic mutations of CBR1:
Generating mutation plots.
Highly correlated genes for CBR1:
Showing top 20/196 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBR1 | MEX3C | 0.731646 | 3 | 0 | 3 |
| CBR1 | AKR1B15 | 0.698874 | 3 | 0 | 3 |
| CBR1 | PRMT6 | 0.695392 | 3 | 0 | 3 |
| CBR1 | MSI2 | 0.692743 | 3 | 0 | 3 |
| CBR1 | GSDMC | 0.683341 | 3 | 0 | 3 |
| CBR1 | MED17 | 0.678118 | 3 | 0 | 3 |
| CBR1 | TSPO | 0.677896 | 3 | 0 | 3 |
| CBR1 | SPATS2L | 0.673663 | 3 | 0 | 3 |
| CBR1 | SRXN1 | 0.672234 | 6 | 0 | 5 |
| CBR1 | PIGM | 0.670662 | 4 | 0 | 3 |
| CBR1 | HDAC3 | 0.661029 | 4 | 0 | 3 |
| CBR1 | AVEN | 0.653733 | 4 | 0 | 3 |
| CBR1 | CYP4F3 | 0.653455 | 9 | 0 | 8 |
| CBR1 | SH3PXD2A | 0.653093 | 3 | 0 | 3 |
| CBR1 | FASTKD2 | 0.652917 | 4 | 0 | 3 |
| CBR1 | DHRS4L2 | 0.649694 | 4 | 0 | 3 |
| CBR1 | LRRC28 | 0.648332 | 4 | 0 | 3 |
| CBR1 | ENTPD3 | 0.647113 | 9 | 0 | 9 |
| CBR1 | HLA-E | 0.640262 | 3 | 0 | 3 |
| CBR1 | SLC30A5 | 0.634929 | 4 | 0 | 3 |
For details and further investigation, click here
