| Full name: 24-dehydrocholesterol reductase | Alias Symbol: KIAA0018|seladin-1 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 1718 | HGNC ID: HGNC:2859 | Ensembl Gene: ENSG00000116133 | OMIM ID: 606418 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DHCR24:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHCR24 | 1718 | 200862_at | -0.0655 | 0.9592 | |
| GSE20347 | DHCR24 | 1718 | 200862_at | -0.9319 | 0.0001 | |
| GSE23400 | DHCR24 | 1718 | 200862_at | -0.6191 | 0.0001 | |
| GSE26886 | DHCR24 | 1718 | 200862_at | -1.6419 | 0.0000 | |
| GSE29001 | DHCR24 | 1718 | 200862_at | -0.9104 | 0.0025 | |
| GSE38129 | DHCR24 | 1718 | 200862_at | -0.2007 | 0.6077 | |
| GSE45670 | DHCR24 | 1718 | 200862_at | -0.2160 | 0.3542 | |
| GSE53622 | DHCR24 | 1718 | 93044 | -0.8411 | 0.0000 | |
| GSE53624 | DHCR24 | 1718 | 93044 | -0.8599 | 0.0000 | |
| GSE63941 | DHCR24 | 1718 | 200862_at | 0.9406 | 0.1787 | |
| GSE77861 | DHCR24 | 1718 | 200862_at | -0.8146 | 0.0113 | |
| GSE97050 | DHCR24 | 1718 | A_23_P379475 | -0.0945 | 0.8979 | |
| SRP007169 | DHCR24 | 1718 | RNAseq | -1.3702 | 0.0002 | |
| SRP008496 | DHCR24 | 1718 | RNAseq | -1.5591 | 0.0000 | |
| SRP064894 | DHCR24 | 1718 | RNAseq | -1.1125 | 0.0004 | |
| SRP133303 | DHCR24 | 1718 | RNAseq | -0.8892 | 0.0027 | |
| SRP193095 | DHCR24 | 1718 | RNAseq | -1.0111 | 0.0000 | |
| SRP219564 | DHCR24 | 1718 | RNAseq | -0.3706 | 0.7230 | |
| TCGA | DHCR24 | 1718 | RNAseq | -0.0110 | 0.8903 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by DHCR24 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHCR24:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHCR24 | 1718 | 3 | 3 | 24 | |
| GSE20123 | DHCR24 | 1718 | 3 | 2 | 25 | |
| GSE43470 | DHCR24 | 1718 | 8 | 2 | 33 | |
| GSE46452 | DHCR24 | 1718 | 2 | 1 | 56 | |
| GSE47630 | DHCR24 | 1718 | 8 | 4 | 28 | |
| GSE54993 | DHCR24 | 1718 | 0 | 0 | 70 | |
| GSE54994 | DHCR24 | 1718 | 10 | 3 | 40 | |
| GSE60625 | DHCR24 | 1718 | 0 | 0 | 11 | |
| GSE74703 | DHCR24 | 1718 | 6 | 1 | 29 | |
| GSE74704 | DHCR24 | 1718 | 2 | 0 | 18 | |
| TCGA | DHCR24 | 1718 | 10 | 19 | 67 |
Total number of gains: 52; Total number of losses: 35; Total Number of normals: 401.
Somatic mutations of DHCR24:
Generating mutation plots.
Highly correlated genes for DHCR24:
Showing top 20/1464 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHCR24 | NIPAL1 | 0.801141 | 3 | 0 | 3 |
| DHCR24 | SNORA68 | 0.79779 | 3 | 0 | 3 |
| DHCR24 | S100A16 | 0.793381 | 7 | 0 | 7 |
| DHCR24 | RAB25 | 0.77657 | 11 | 0 | 11 |
| DHCR24 | GRHL1 | 0.759304 | 7 | 0 | 7 |
| DHCR24 | CKMT1A | 0.747125 | 3 | 0 | 3 |
| DHCR24 | RASSF5 | 0.745978 | 7 | 0 | 7 |
| DHCR24 | GRHL3 | 0.742063 | 8 | 0 | 8 |
| DHCR24 | MFSD5 | 0.741932 | 11 | 0 | 11 |
| DHCR24 | ASPG | 0.74084 | 5 | 0 | 5 |
| DHCR24 | MAPK13 | 0.738599 | 10 | 0 | 10 |
| DHCR24 | SSU72 | 0.735346 | 3 | 0 | 3 |
| DHCR24 | ARHGAP32 | 0.732621 | 11 | 0 | 11 |
| DHCR24 | ANKRD22 | 0.730148 | 5 | 0 | 5 |
| DHCR24 | SYTL1 | 0.729892 | 8 | 0 | 7 |
| DHCR24 | FAM135A | 0.729555 | 7 | 0 | 7 |
| DHCR24 | ARAP2 | 0.72709 | 3 | 0 | 3 |
| DHCR24 | CERS3 | 0.725013 | 7 | 0 | 7 |
| DHCR24 | GALE | 0.724343 | 11 | 0 | 11 |
| DHCR24 | NMU | 0.723254 | 11 | 0 | 11 |
For details and further investigation, click here
